Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 17 of 17 for “"XPC"”.
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XPC Haplotypes Alter DNA Repair Capacity and Levels of Genetic Damage
Xeroderma pigmentosum complementation group C (XPC) is the key recognition factor of DNA damage in global genome nucleotide excision repair (NER). The disease Xeroderma pigmentosum (XP) results from mutations leading to structural defects of the encoding gene and in some instances trace to changes …
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Light-induced modulation of DNA recognition by the Rad4/XPC damage sensor protein.
… by the xeroderma pigmentosum C complex (XPC-Rad23B; Rad4-23 in yeast). Rad4/XPC specifically recognizes various bulky helixdestabilizing/distorting lesions in the genomic DNA to initiate the global genome nucleotide excision repair (GG-NER) pathway in eukaryotes. This dissertation reports …
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Effect of a Fermented Yeast Product on the Gastrointestinal Tract Microbial Diversity of Weaned Pigs Challenged With Salmonella Enterica Typhimurium Dt104
… Saccharomyces cerevisiae fermentation product (XPC, Diamond V Mills, Inc., Cedar Rapids, IA) inclusion in nursery diets on the microbial diversity and growth performance of pigs before, during and after an oral challenge with Salmonella. Pigs (n= 40) were weaned at 21 d of age, blocked by body …
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Strahleninduzierte Genexpression von Zellzykluskontroll- und DNA-Reparaturgenen als Biomarker für individuelle Strahlenempfindlichkeit
… von CDKN1A (p21, Cip1, WAF1), PCNA, TP53, XPC, GADD45A und DDB2 4h nach Bestrah¬lung in vitro bestimmt. Die erhaltenen Induktionswerte wurden mit dem Ausmaß der Neben¬wir¬kun¬gen ver¬glichen, die die Patienten während ihrer Bestrahlung tatsächlich entwickelten. Zum besseren Verständnis der …
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Xeroderma-Pigmentosum-Gruppe-C- und -G-Gen-Polymorphismen: Alternatives Splicing und funktionelle DNA-Reparatur beim multiplen Melanom
… herauszufinden, ob genetische Variationen in den XPC- und XPG-Genen zur Melanomentwicklung beitragen, untersuchten wir Polymorphismen, alternatives Splicing und funktionelle DNA-Reparatur in einem Hochrisikokollektiv von 30 Patienten mit sporadischen multiplen Melanomen und 30 entsprechenden …
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A Molecular Approach to Understanding the Effects of Original-XPC on the Modulation of the Cecal Microbiota and the Survival of Salmonella in the Poultry Host
… trial to determine the effects of Original-XPCTM (XPC; a compound similar to a prebiotic) on Salmonella survival and cecal microbiota modulation. The in vitro study resulted in rapid and significant reduction (from approximately 1.0 to 2.0 logs) of the survival of Salmonella in the XPC …
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Modeling and Development of Iterative Reconstruction Algorithms in Emerging X-ray Imaging Technologies
… (CBCT), and in-line X-ray phase contrast (XPC) tomosynthesis. For each imaging modality, one or more specific problems prevent them being effectively or efficiently employed in clinical applications have been discussed. Firstly, to mitigate the long data-acquisition times and large …
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Proteômica comparativa de linhagens celulares humanas expostas a estresse oxidativo induzido por riboflavina fotossensibilizada
… NER enzymes deficiency, such as CSB and XPC, acting in the damage recognition step in the two subways this system influences the effectiveness of oxidative damage repair. However, the mechanisms by which cells deficient in these enzymes respond to oxidative stress and its consequences …
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Improving Feed Efficiency Through Forage Strategies for Increasing Dairy Profitability and Sustainability
… products (SCFP); (Diamond V original XPC and two prototypes) on lactational performance and ruminal fermentation. Eight ruminally cannulated Holstein dairy cows were used in a replicated 4 x 4 Latin square. Treatments were: 1) Control (C): corn silage and haylage based ration; 2) XPC: …
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Developing a Microbubble-based Contrast Agent for X-ray Phase Contrast Imaging to Detect Neovasculature in Breast Cancer
X-ray phase contrast imaging (XPC) generates contrast from refraction and scattering of X-rays, unlike absorption in conventional radiology. This technique greatly improves the sharpness of boundaries and reveals micro-structured tissues that are not easily detected by conventional absorption-based …
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Development of a High Speed Data Acquisition System for Spark Ignition Engine
… had to be developed. Using Matlab/ Simulink, xPC Target and data acquisition hardware a model of the single cylinder engine was developed. These models were developed by taking measurements of the engines dynamics such as engine speed, crank angle, air mass intake, spark timing, injection …
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Creazione e sviluppo di un sistema di controllo in tempo reale per un sistema fuel cell
… Mathworks` Real Time Workshop (RTW) and the xPC development suite for MiL (model-in-theloop) and HiL (hardware-in-the-loop) testing. It is possible to completely develop, verify and validate the controller application without depending on the real fuel cell system, which is not available for …
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Deformability and Dynamics in Linear and Looped/Supercoiled DNA with Implications for Damage Sensing
… proteins: 1) Rad4 (yeast ortholog of human XPC), which recognizes DNA lesions from UV-light and other environmental genotoxins and initiates nucleotide excision repair; 2) MutS, which recognizes single mismatches or unpaired nucleotides introduced during replication and initiates mismatch …
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Distributed real-time hybrid simulation: Modeling, development and experimental validation
… environment is provided based on MATLAB/xPC. In this method, (i) a buffer is added to the simulation loop to minimize network jitter and stabilize the transmission rate, and (ii) a routine is implemented to estimate the network time delay on-the-fly for the optimal operation of the Smith …
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Einfluss der Immunsuppressiva Cyclosporin A und Everolimus auf die funktionelle DNA-Reparaturfähigkeit sowie auf die Regulation von DNA-Reparatur-Genen
… A verminderte die mRNA-Expression von XPB, XPC, XPD und XPG. Auf Proteinebene führte Cyclosporin A lediglich zu einer reduzierten XPA- und XPG-Proteinexpression. Durch Überexpression von XPA und XPG in normalen und XP-defizienten Fibroblastenzelllinien konnte die funktionelle Bedeutung …
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Fuzzy Analysis of Speech Metrics to Estimate Crew Alertness
… was realized through the Matlab/Simulink xPC Target toolbox which allowed for instant real time code generation, testing and modification. This testing environment together with batch mode testing was used to extensively test and fine tune parameters to improve the performance of the …
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Heat stress: A risk factor for skin carcinogenesis
… probes for BAX, Survivin (BIRC5), ERCC1 and XPC genes, with Human 18S gene as the endogenous reference gene. Relative quantification of the expression levels of each transcript in each sample were calculated using the Delta-Delta CT method relative to untreated controls. A whole genome …