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Showing 1 to 11 of 11 for “"XPA"”.
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Nucleotide Excision Repair, Crosslink Repair and Transcriptional Function of Xpa In Human Cells
… includes xeroderma pigmentosum group A protein (XPA) as a core factor. XPA and other NER proteins have been detected previously at some active promoters, and NER deficiency is reported to decrease activated transcription of selected genes. To determine the global extent of XPA influence on …
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New Insights into the Roles of Human DNA Damage Checkpoint Protein ATR in the Regulation of Nucleotide Excision Repair and DNA Damage-Induced Cell Death
… with NER factor xeroderma pigmentosum group A (XPA) where an ATR phosphorylation site on serine 196 is located. Phosphorylation of XPA on serine 196 is required for repair of UV-induced DNA damage. In addition, a K188A point mutation of XPA that disrupts the ATR-XPA interaction inhibits the …
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Einfluss der Immunsuppressiva Cyclosporin A und Everolimus auf die funktionelle DNA-Reparaturfähigkeit sowie auf die Regulation von DNA-Reparatur-Genen
… anhand von Expressionsanalysen alle XP-Gene (XPA bis XPG) darauf hin untersucht, ob sie von Cyclosporin A auf mRNA- oder Proteinebene differenziell reguliert werden. Cyclosporin A verminderte die mRNA-Expression von XPB, XPC, XPD und XPG. Auf Proteinebene führte Cyclosporin A lediglich zu …
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Building bioinformatics solutions for biomarker identification
… be investigated. Together this toolset was named XPA [for ‘Cross Platform Analysis’]. The XPA system was tested by using it to house and analyse data from two different medical studies, one using quantitative PCR [qPCR] to observe gene expression changes in prostate cancer, and the second using …
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Structural and Biochemical Investigation of the Molecular Mechanisms of DNA Response and Repair in Humans and <em>Escherichia coli</em>.
… NER factor Xeroderma pigmentosum group A (XPA) in both a dose- and time-dependent fashion. Also, using surface topology mapping we have defined an α-helix motif on XPA required for XPA-ATR complex formation necessary for XPA phosphorylation. In addition, we have determined that XPA …
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1, Structural and Functional Studies of Human Replication Protein A; 2 DNA Damage Responses and DNA Repair Defects in Laminopathy-Based Premature Aging.
… Strikingly, xeroderma pigmentosum group A (XPA), a unique NER protein, formed foci and colocalized with the unrepairable DSBs in the patient cells. RNAi knockdown of XPA in HGPS cells significantly restored DSB repair. These results indicate that XPA dysfunction may play an important role in …
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Detection of Novel Genomic Markers for Predicting Prognosis in Hepatocellular Carcinoma Patients by Integrative Analysis of Copy Number Aberrations and Gene Expression Profiles: Results from a Long-Term Follow-Up
… that the low expression of TLE4 (P=0.041) and XPA (P=0.006) were associated with poor OS. In the analysis of tumor recurrence, 514 genomic regions with CNAs were associated with recurrence. Integrative analysis revealed that the overexpression of 16 genes including FGR (P=0.003), RELA …
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Somatic microsatellite variability as a measure of DNA stability in cancer and DNA repair disorders
… xeroderma pigmentosum, caused by the loss of the XPA or XPB genes; Werner syndrome, caused by the loss of the RecQL2 gene; and Rothmond-Thomson syndrome, caused by the loss of the RecQL4 gene. The goal of this project was to determine if impaired excision repair genes CSA or global XPA and B or …
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Organised Chaos: defining different degrees of intrinsic disorder by molecular dynamics methods
… of macromolecular assemblies, such as the XPA in the Nucleotide Excision Repair (NER) pathway, to regulatory and signalling functions, such as p53 and short linear motifs (SLiMs)-containing regions. Trying to understand the relationships between structure and functions in these highly …
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A STUDY OF THE INTERPLAY BETWEEN SACCHAROMYCES CEREVISIAE TRANSCRIPTION AND DNA REPAIR.
… Rad14p (associated with Xeroderma Pigmentosum, XPA- in humans), and for the first time demonstrated its function in transcription initiation in the absence of DNA damage. Finally, I analyzed whether repair of double strand breaks could be connected to transcription via an elegant method …
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Estudio multiple de polimorfismos genéticos en pacientes con linfoma de células B maduraú
… así como rupturas en el esqueleto del ADN. Ø XPA-rs1800975, el nombre proviene de la enfermedad que ocasiona el déficit Xeroderma Pigmentosum, es una enzima que forma parte de los sistemas de reparación del DNA son proteínas que escanean el DNA para detectar alteraciones. Ø ERCC5-rs17655 del …