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Development of synthetic RNA-targeting catalysts from biostable nucleic acid analogues

Donde, MariaUniversity of Cambridge2025

… of catalysts entirely composed of XNAs, “XNAzymes”. Our aim here is to evolve, engineer, and test RNA-cleaving XNAzymes capable of targeting disease-associated RNA under physiological conditions. This approach seeks to overcome the limitations of other RNA knockdown methods, principally …

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