Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 76 for “"XENOGRAFT MODEL"”.
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Bevacizumab Effect on Topotecan Pharmacokinetics in a Murine Orthotopic Rhabdomyosarcoma Xenograft Model
… in an Rh30 orthotopic rhabdomyosarcoma xenograft model. However, the effects of BEV on the pharmacokinetics of TPT and the antitumor activity of TPT have not been evaluated. This study aimed to investigate the effect of BEV on TPT systemic and tumoral pharmacokinetics and to determine …
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Development of the chick chorioallantoic membrane (CAM) xenograft model to study metastasis and angiogenesis in autophagy deficient osteosarcoma cells
… the CAM assay as a physiologically relevant model to understand OS metastasis and angiogenesis, and how the expression of cancer markers may vary in a 3D environment when autophagy is suppressed. In this study, the CAM assay was completed in 13 embryonic development days (EDD). After several …
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An Investigation into the Potential of Cell Therapies for Acute Myeloid Leukemia (AML) Treatment
… cells and extended survival in a Molm-13 GFP Luc xenograft model. Vγ9Vδ2 T cells also exerted an effective apoptotic effect in combination with venetoclax in the venetoclax resistant cell line, OCI-AML3, and improved survival in an OCI-AML3 GFP Luc xenograft model.</p>
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Estrogen Inducible Serpin, Proteinase Inhibitor 9, in Immunosurveillance and Apoptosis
… Analysis of MCF-7 tumors produced in a mouse xenograft model shows that genistein, soy-products including soy flour and NovasoyRTM induce PI-9 expression in vivo. Our data highlight the possibility that low concentrations of genistein might promote growth of pre-existing estrogen …
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Effects of Liposome-Encapsulated TNF-Alpha and Radiation against Colon Cancer
… effects in the LS174T human colorectal tumor xenograft model compared to the combination of free TNF-α and radiation, as well as to each modality alone. Furthermore, the increased antitumor efficacy of SL-TNF-α plus radiation will be associated with greater and more prolonged augmentation of …
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Methylation of Egfr By Arginine Methyltransferase Prmt1 Enhances Egfr Signaling and Cetuximab Resistance
… mutant reduced tumor growth in mouse orthotopic xenograft model. Importantly, increased EGFR methylation sustains its signaling activation and cell proliferation in the presence of therapeutic EGFR monoclonal antibody, cetuximab. EGFR methylation level also correlates with higher recurrence rate …
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Novel Drug Discovery for Glioblastoma Multiforme Using Brain Tumour Initiating Cells
… in overall median survival in an orthotopic BTIC xenograft model. Altogether, these data strongly support further investigation of this compound and potentially represent the first step toward an effective molecularly targeted therapeutic for GBM.
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Overcoming Acquired Resistance to BRAF Inhibitors by Novel Synergistic Drug Combination and Discovery of Novel Smac Mimetics as Selective Survivin Inhibitors
… efficacy in the vemurafenib-resistant xenograft model in nude mice. Overall, these results offer a rational combination strategy to significantly enhance the therapeutic benefit in melanoma patients who inevitably become resistant to current BRAF inhibition therapy.</p> <p>The second …
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Investigating the role of PTPRK in homeostasis and disease
… during essential processes, such as junctional remodelling. Plasma membrane-localised receptor PTPs (RPTP) are well positioned to sense external environmental cues, such as cell-cell contact, and transmit signals via their intracellular domains. Using unbiased approaches we find RPTP, PTPRK binds …
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Polymerizable Peptide Monomers for the Targeted and Intracellular Delivery of Cancer Therapeutics
… carrier via disulfide exchange. In a murine xenograft model of B-cell lymphoma, steric hindrance significantly enhanced conjugate stability, peptide half-life and peptide deposition into tumors. However, benefits were relatively minor with much left to be desired. Next an enzyme-labile …
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Influencing Pathways that Cause Metastasis and Stemness in Epithelial Ovarian Cancer
… was also assessed as described above and in a xenograft model. It was determined that the cell lines show varying phenotype from epithelial like to mesenchymal like morphology and the cell lines have varying concentrations of cancer stem cells. It was also determined that the CSC population of …
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TREATMENT AND MODELING OF EPSTEIN-BARR VIRUS POST-TRANSPLANT LYMPHOPROLIFERATIVE DISORDER
… antibody (α-EBNA-1 TCR-like mAb) using a mouse xenograft model of PTLD. With the aim of translating our findings into studies relevant to humans, we developed and optimized an autologous humanized mouse model for future preclinical evaluations of the antibody
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Novel mechanism of gastric proton pump inhibitor (PPI) : Suppression of Helicobacter-pylori induced angiogenesis and selective induction of apoptosis in gastric cancer cells.
… effect of PPZ was evaluated in vivo by a xenograft model of nude mice. And, to address the relationship between H.pylori infection and angiogenesis, comparative analysis of density of CD34+ blood vessel was performed in tissues obtained from 20 H.pylori positive gastritis and 18 H.pylori …
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The Impact of Radiation on Glioblastoma Evolution
… glioma stem-like cell (GSC) initiated orthotopic xenografts, and by assessing radioresistance with a reirradiation protocol. To determine the impact of ITH on intrinsic radiosensitivity, we performed whole-exome sequencing (WES) of multiple tumour fragments and corresponding patient-derived cell …
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Cxcr2 Macromolecular Complex In Pancreatic Cancer: A Potential Therapeutic Target In Tumor Growth
… In addition, using a human pancreatic tumor xenograft model, we show that gene delivery of CXCR2 C-tail sequence (containing the PDZ motif) by adeno-associated virus type 2 viral vector potently suppresses human pancreatic tumor growth in immunodeficient mice. In summary, our results suggest …
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Characterisation of HIF2A targets identifies MYC as a key determinant of HIF2A dependency in ccRCC
… that HIF2A can be acutely degraded in a xenograft model of ccRCC using AID2 technology, and that combining this with RNA-seq uncouples direct targets from downstream signalling cascades. This unbiased method enabled the shortlisting of clinically relevant candidate HIF2A direct target …
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Role of Hypoxia-inducible Factor in Kidney Cancer
… manner both in vitro and in a mouse xenograft model. This work provides pre-clinical evidence for the potential use of EMCV in an oncolytic virus-based approach to the treatment of advanced ccRCC. In addition, using a cell biology-based approach we reveal that inhibition of the DNA …
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Probing the Molecular Requirements for Breast Cancer Cell Motility
… pathways. Furthermore, using, an orthotropic xenograft model, we determined that deltaNp63alpha and Slug functionally contribute to the induction of collective invasion in vivo. Together, our results suggest a deltaNp63alpha dependent signaling through miR205, Axl, and Slug can lead to the …
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Delineating the Mechanisms Through Which ZNF165 Supports Growth and Survival of Triple-Negative Breast Cancer
… TNBC tumor growth in vivo using an orthotopic xenograft model in immunocompromised mice. Moreover, my data also suggest that ZNF165 is SUMOylated by TRIM27 to enhance its protein stability, providing further insight into the mechanisms that regulate ZNF165 activity in TNBC. Together, my …
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