Global ETD Search
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Showing 1 to 3 of 3 for “"XChem"”.
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Developing Chemical Tools for the Inhibition of Activin A Signalling
… targeted mature activin A through the use of XChem, conducting a fragment screen against mature activin A crystals. I describe the identification of twelve fragment hits that bind in the putative type I receptor binding site and the validation and optimisation of one of these fragments. I then …
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Synthesis of Partially Saturated Bicyclic Heteroaromatics: sp3-Enriched Scaffolds for Drug Discovery
… library has been incorporated into the Diamond XChem high-throughput crystallography program and initial screening has identified a weakly binding hit for Activin A.
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Synthesis of Structurally Diverse N-Substituted Quaternary Carbon Containing Small Molecules and Their Application as Novel Starting Points for Drug Discovery
… coupling of rapid analogue construction with the XChem screening platform to provide a direct structural-binding readout via screening of crude reaction mixtures. In this section, we demonstrate the applicability of this library toward high-throughput derivative synthesis using solid-phase …