Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 3 of 3 for “"XBP1s"”.
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Altered Responses to Endoplasmic Reticulum Stress In Pancreatic Cancer
… the UPR were assessed: eIF2α/ATF4/CHOP and IRE1α/XBP1s. Pancreatic cancer cells exhibited altered UPR activation characterized by a delay in both phosphorylation of eIF2α and induction of spliced XBP1. Further evaluation of the UPR-mediated effects on cell cycle progression revealed that …
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Antiproliferative activities of Euphorbia bicolor (euphorbiaceae) and Maclura pomifera (moraceae) extracts on estrogen receptor-positive and triple-negative breast cancer cell lines
… markers caspase 3, caspase 9, caspase 8, FAS, XBP1s, CHOP, and BAX, and reducing BCL-2 levels. PI3K/AKT pathway inhibition was observed in both cell lines. These findings suggest that Maclura pomifera and Euphorbia bicolor phytochemicals could be promising candidates for breast cancer …
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Identification of a Novel Regulator of ER Stress-Induced Apoptosis
… the potent transcription factor spliced Xbp1 (Xbp1S). If the ER cannot return to homeostasis, the apoptotic program is activated. Programmed cell death (apoptosis) is an evolutionarily conserved, genetically controlled program which eliminates excess or irreparably damaged cells and it is …