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Showing 1 to 13 of 13 for “"X-ray structure determination"”.
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Tetraazamacrocyclic ligands and their copper complexes
… appears to proceed regioselectively. An X-ray structure determination of the copper complex of 5,12-dimethyl-5,6,11,12, 18,19,20,21-octahydro-17-H-tribenzo (f,j,n)(1,5,9,12) tetraazacyclopentadecine shows this to be meso-dimethyl isomer. Condensation of 2,2 '-(oxalyldiimino)bisbenzophenone …
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Dynamics and Mechanism of Spin-State Interconversion in Iron Spin-Crossover Complexes
… spectroscopic techniques and single-crystal X-ray structure determination.
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Studies on Structure and Dynamics of Components of Phytochrome Mediated Light Signaling in Plants and Cyanobacteria
… tremendous research activity in the field, no X-ray or NMR-based structural information is available. For the first time now, the crystal structures of two cyanobacterial response regulators (RR), which directly interact with bacterial phytochrome receptors, have been solved. This could be …
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Low Resolution ab initio Phasing Method by Modification of Density and Phase in Real and Reciprocal Space
Phasing problem in X-ray structure determination can be challenging. Several methods, such as Isomorphous Replacement and Molecule Replacement, are frequently used. But their success relies on the availability of either an isomorphous heavy-atom derivative or a high identity homologous model. In …
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The Total Synthesis of (-)-Prezizaene, (-)-Prezizanol, and Other Perzizanoid Sesquiterpenes
… as a single isomer after crystallization. An X-ray structure determination confirmed the all cis stereochemistry at the three chiral centers. Reduction and hydrolysis afforded a dimethyl ketone which was identical with a sample prepared independently.
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Supramolecular derivatives of selected bioactive compounds : a physicochemical study
… for hostguest stoichiometric assay and purity determination respectively. X-ray powder diffraction and single crystal X-ray structure determination were used for structural analysis.
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Synthesis, crystallography and biological activity of myo-inositol phosphates
… 1,2,3-trisphosphate represents the simplest structure to mimic phytate's antioxidant activity has been tested. The first synthesis of myo-inositol 1,2,3-trisphosphate has been completed, along with its X-ray structure determination and that of key synthetic intermediates. Iron binding studies …
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Microfluidic platforms for protein crystallization and in situ X-ray analysis
"Recent efforts associated with the Protein Structure Initiative from the National Institutes of Health (NIH) have eased the bottlenecks associated with protein expression, purification, and crystallization for structural analysis. While strategies have been developed for dealing with each of these …
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A reevaluation of distortional isomerism.
… Both solid state (XPS, Raman, infrared, powder X-ray diffraction) and solution phase (¹H NMR, UV-visible, EPR, cyclic voltammetry) measurements were applied to the respective green materials, presenting a consistent description of their composite nature. A single crystal X-ray structure …
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Modulation of BAZ2 Proteins as a Potential Therapeutic Strategy in Cancer and Neurological Disorders
… molecules were designed based on available BAZ2A structures. The synthesis of eleven BAZ2A degraders was accomplished, categorizing PROTACs according to their capability to recruit CRBN or VHL E3 ligases. Preliminary experiments revealed that VHL-based degraders featuring longer linkers promoted …
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Physicochemical characterisation of cyclodextrin-drug complexes
… of sufficient quality for single crystal X-ray structure determination. The designated drugs included an antibacterial, sulfathiazole; three non-steroidal anti-inflammatory drugs (NSAIDs), (S)-naproxen and the sodium salts of diclofenac and meclofenamic acid; and (L)-menthol, a compound used …
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Kristallstrukturen der L-Rhamnulose-1-phosphat-Aldolase aus Escherichia coli
In dieser Arbeit wurde die Raumstruktur der L-Rhamnulose-1-phosphat-Aldolase (RhuA) aus Escherichia coli aufgeklärt und analysiert. Das Enzym katalysiert die reversible Aldolspaltung von L-Rhamnulose-1-phosphat in L-Lactaldehyd und Dihydroxyacetonphosphat (DHAP). Ausgehend von einer komplizierten …