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Showing 1 to 20 of 108 for “"X-ray Crystal Structure"”.
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X-Ray Crystal Structure of Au36(SPh-pCH3)24 Nanomolecules
… most comNanomolecules (NM) in gold NM field and crystal structures of Au36(SR)24 with different thiolate protecting ligand such as tert-butylbenzene thiol, thiophenol and cyclopentane thiol have been reported. It has been predicted that aromatic thiol protected Au36(SR)24 NM have same core …
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The Application and Use of Punched Cards and International Business Machines in X-Ray Crystal Structure Analysis
Made available in DSpace on 2015-05-12T17:02:26Z (GMT). No. of bitstreams: 2 license.txt: 4848 bytes, checksum: 96035ab3f5e1c23cc7138a224ce498bd (MD5) 0006006.PDF: 7330485 bytes, checksum: 6b0c354177f2ce10cce4edc216401ca9 (MD5) Previous issue date: 1953
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X-Ray crystal structure of a ribosomal protein S6, S15, S18 : rRNA complex from T. thermophilus, and investigation of conformational changes in 16S rRNA fragments from B. stearothermophilus during ribonucleoprotein assembly
The X-ray crystallographic structure of a fragment of the 30S ribosomal subunit from Thermus thermophilus containing ribosomal proteins S6, S15, S18, and a minimal rRNA binding site (T4 RNP) containing two different three-helix junctions was solved to 2.6 A. The protein S15 contains four bundled …
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Structural and spectroscopic studies with dithizone and its derivatives
An X-ray crystal structure detennination of 3-nitro-l,5-di(2,6-dimethylphenyl) fonnazan, ArN:N•C(N02):N•NHAr (Ar= 2,6-dimethylphenyl), has shown that the N-N-C-N-N chain is stabilized by an unusual hydrogen bond in the closed-ring syn,s-cis configuration relative to the formal double C=N and single …
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Design and Synthesis of Novel Benzimidazoles and Aminothiazoles as Small Molecule Inhibitors of CDK5/p25
… disease (AD). Based on the deposited X-ray crystal structure of CDK5/p25 with a non-selective CDK inhibitor R-Roscovitine (PDB ID: 1UNL), eight series of novel compounds with a benzimidazole core were designed, synthesized and tested as inhibitors of CDK5/p25. An efficient synthesis of …
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Synthesis and Characterization of Derivatives of Triironnonacarbonyl Ditelluride and Related Compounds
… adducts at theexpense of an Fe-Fe bond. An X-ray crystal structure of the adductFe(,3)Te(,2)(CO)(,9)PPh(,3) reveals a pentagonal bipyramid with two oppositeequatorial vertices unoccupied. These adducts lose CO upon
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Synthesis and properties of novel cage-functionalized crown ethers and cryptands.
… alkali metal-complexes was performed. The X-ray crystal structure of a K+-complexed bis-cage-annulated 20-crown-6 was obtained. The associated picrate anion was found to be intimately involved in stabilization of the host-guest complex. The interaction energy between the host-guest complex …
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Structural Determinants for Inhibitor Recognition by the Dopamine Transporter
… was generated in our laboratory based on the X-ray crystal structure of the bacterial leucine transporter LeuT, a distant homolog of DAT. The ability of this LeuTAa-based 3-D DAT computer model to identify specific DAT residues involved in inhibitor recognition was assessed through site-directed …
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Preparation, Properties, and Catalytic Activity of Fluorous Phosphine Substituted Transition Metal Carbonyl Complexes
… 31P NMR data are compared and contrasted. The X-ray crystal structure of W(CO)5{P(p-C6H 4-CH2CH2(CF2)7CF3) 3} was determined. The fluorocarbon soluble, binuclear ruthenium(I) complexes [Ru(mu-O2CMe)(CO)2L], where L is a perfluoroalkyl substituted tertiary phosphine, P(p-C6H4 -CH2CH2(CF2)7CF3) 3 …
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Structural characterization of glycyl radical enzymes in the human gut microbiome
… In this thesis, I present and describe an X-ray crystal structure of IslA from Bilophila wadsworthia with isethionate bound.
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Design, Synthesis and Evaluation of Diphenylamines as MEK5 Inhibitors
… based on a homology model of MEK5 using the X-ray crystal structure of MEK1 (PDB ID: 3EQC) as a template. The compounds were tested for their MEK12, and MEK5 inhibition in a cell based assay.
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Preparation and evaluation of several new pi-basic chiral stationary phases
… stationary phases. Proton NMR studies and an X-ray crystal structure are discussed and provide additional support for the proposed chiral recognition model between N-(3,5-dinitrobenzoyl)amino acid derivatives and N-arylamino acid derived CSPs.
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Synthesis, characterisation and coordination chemistry of novel N-alkyl- and N,N-dialkyl-N'-acylthioureas
… are synthesised and characterised. The crystal structure of N-butyl-N'-benzoylthiourea indicates that an intramolecular hydrogen bond locks the potentially bidentate chelate moiety into a planar six-membered ring with an overall rod-like molecular structure. The rod-like structure of the …
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Synthesis, structure and reactivity of chiral cyclopentadienylruthenium(II) complexes
… which are preparedanalogously. An X-ray crystal structure determined for (±)-[(rj 5 -C 5 H5)Ru(PPh 3 )-(CNtBu)(Me 2 SO)]PF6 is also discussed.The fourth chapter describes the preparation of the chiral ligand S(-)-oc-methylbenzylisonitrileby Phase-Transfer Hoffmann Isocarbylamine …
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Structural and ligand binding studies of toll-like receptor 4 (TLR4) associated proteins
… information. Thus, we determined the x-ray crystal structure of human CD14, the results of which were recently published (Kelley, S.L., et al., (2013). J. Immunol. 190:1304-1311) and are presented in Chapter 2 of this dissertation. To do so, we cloned, expressed, and purified two …
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The crystal and molecular structure of thiamine hydroiodide /|nWilliam Edward Lee. -- 260 St. Catharines [Ont.] : Dept. of Chemistry, Brock University,
The x-ray crystal structure of thiamine hydroiodide,C1ZH18N40S12' has been determined. The unit cell parameters are a = 13.84 ± 0.03, o b = 7.44 ± 0.01, c = 20.24 ± 0.02 A, 8 = 120.52 ± 0.07°, space group P2/c, z = 4. A total of 1445 reflections having ,2 > 2o(F2), 26 < 40° were collected on a …
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Bioorganic activation of cytochrome P-450cam
… due to the availability of a high resolution X-ray crystal structure. In this thesis several questions concerning the activation of P-450cam by substrate, electron transfer and oxygen cleavage are addressed. The identity of the cysteine ligands to the (2Fe-2S) center of P-450cam's electron …
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Redesigning specificity in miniproteins
… stoichiometry as its parent homotetramer. The x-ray crystal structure of the heterotetramer revealed a structure very close to the designed structure with near-perfect prediction of core side-chain packing. In a second round of design, the BBA heterotetramer was stabilized to near-native …
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Synthesis of molybdenum olefin metatheses catalysts through protonation reactions
… Mo(NHArc,)(C-t-Bu)[Biphen] in 40% yield. An X-ray crystal structure of a related complex, Mo(NHArc,)(CCMe2Ph)[S-Biphen] confirmed the proposed structure and also revealed that one ortho chloride approaches within 2.93 A of the metal approximately trans to the alkylidyne ligand. Attempts to …
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Structure-Function Relationship Studies of the Rhodobacter Sphaeroides Cytochrome AA(3)
… of a putative proton channel identified in the X-ray crystal structure of the cytochrome c oxidases from bovine heart mitochondria and P. denitrificans has been studied using site-directed mutagenesis coupled with a variety of biophysical characterization methods. Based on the work done, it is …
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