Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"X-linked inhibitor of apoptosis protein"”.
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Expression of X-linked Inhibitor of Apoptosis Protein in Neoplastic Thyroid Disorder
X-linked inhibitor of apoptosis protein (XIAP) is associated with tumor genesis, growth, progression and metastasis, and acts by blocking caspase-mediated apoptosis. In the present study, we sought to evaluate the expression patterns of XIAP in various neoplastic thyroid disorders and determine the …
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Role of X-Linked Inhibitor of Apoptosis Protein in Therapeutic Resistance of Inflammatory Breast Cancer Cells
<p>Apoptotic dysregulation is a hallmark of cancer cells. The inability of cancer cells to undergo apoptosis may lead to therapeutic resistance. Inflammatory breast cancer (IBC) is a highly aggressive subtype of breast cancer that is often characterized by ErbB2 overexpression and ErbB2 activation. …
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Is It Memory or Is It Death? Caspase-3 and Memory Formation
… Stroke, Alzheimer's and Parkinson's. Activation of caspase-3 is normally thought of as the terminal step in the biochemical cascade of apoptosis (programmed cell death). However, it is present in healthy adult neurons. Is it being expressed, potentially for decades, by these healthy cells in …
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Characterisation of a protease-dependent gene regulation system for gene therapy applications
… is a promising approach for the treatment of a wide range of chronic diseases. These therapies typically utilise strong, constitutively active promoters to drive high levels of recombinant protein expression. Unregulated gene expression is a key issue limiting clinical translation of …
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Investigating a novel small molecule inhibitor of nuclear import as an anti-cancer approach
The identification of novel cancer-associated biomarkers against which drugs can be developed is anticipated to be beneficial in multiple ways; including their use as monotherapies and in combination with current chemotherapeutic agents for improved anti-cancer treatment outcome. Recently, research …
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Nanotherapies for Treating Prostate Cancer
… physiological barriers which hinder efficacy of anticancer agents. Therefore, the focus of this study was to investigate a new combination therapy approach for treating prostate cancer and develop polymeric nanocarriers to facilitate anticancer drug and nucleic acid delivery.</p> <p>It was …
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Discovery of Inhibitors of Inhibitors of Apoptosis Proteins and Novel Tubulin Polymerization Inhibitors as Potential Anticancer Agents
<p>The global impact of cancer as a significant public health concern is undeniable. According to the annual report by the American Cancer Society, projections for 2023 estimate 1,958,310 new cancer cases and 609,820 cancer-related deaths in the US. Recent years have seen significant progress in …
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Advances in high-throughput screening: better compounds, novel targets, enhanced sensors
… in modern drug discovery. Through the evaluation of large structure collections, novel drug leads can be rapidly assessed for modulation of medicinally-relevant biological targets. This occurs through the interplay of three intrinsically linked facets, namely A) the chemical collections being …