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Showing 1 to 20 of 124 for “"X-chromosome"”.

  1. Chromatin structure of the inactive X chromosome

    Gilbert, Sandra L. (Sandra Leigh), 1968-Massachusetts Institute of Technology1999

    Thesis (Ph.D.)--Massachusetts Institute of Technology, Dept. of Biology, 1999.

    mit Repository record

  2. X chromosome studies and breast and ovarian carcinoma

    Harbord, Sara Helen AlisonUniversity of British Columbia2007

    Skewed somatic X inactivation (XCI), X-linked gene overexpression and abnormal X content have been associated with breast and ovarian cancer. Partial or complete reactivation of the inactive X in females may be a step in breast and ovarian cancer progression, leading to overexpression of some …

    ubc Repository record

  3. Histone modification and the epigenetics of X chromosome inactivation

    Spotswood, Hugh TimothyUniversity of Birmingham2003

    … majority of the genes on one of the two female X chromosomes. The inactive X chromosome (Xi) differs from its active homologue in a number of ways, including the hypoacetylation of core histones, a common property of genetically inactive chromatin. This study has used Xi to explore the functional …

    birmingham Repository record

  4. Evolution of large palindromes on the primate X chromosome

    Jackson, Emily KatherineMassachusetts Institute of Technology2021

    Human sex chromosomes are enriched for complex genomic architecture, including massive palindromes with arms that can exceed 1 Mb in length and arm-to-arm sequence identity higher than 99%. Palindrome arms harbor protein-coding genes with testis-biased expression, suggesting roles in male …

    mit Repository record

  5. Autosomal random asynchronous replication is analogous to X-chromosome inactivation

    Ensminger, Alexander WilsonMassachusetts Institute of Technology2006

    … appears to be coordinated at the level of entire chromosomes. This regulatory scheme is reminiscent of random X-chromosome inactivation, the dosage compensation machinery in mammals. We have shown that autosomal coordination responds to trisomy in a fashion similar to X inactivation, with one copy …

    mit Repository record

  6. The role of Xist RNA in the maintenance of X chromosome inactivation

    Csankovszki, Györgyi, 1971-Massachusetts Institute of Technology2001

    … Xist RNA were found to act synergistically in X chromosome silencing. To investigate whether Xist RNA can also silence the active X chromosome of male somatic cells, Xist expression on the active X was induced by demethylation. Demethylation was achieved by Cre mediated deletion of a conditional …

    mit Repository record

  7. Studies on X chromosome inactivation and the X-linked disease Rett syndrome

    Luikenhuis, Sandra, 1972-Massachusetts Institute of Technology2004

    (cont.) the RTT phenotype.

    mit Repository record

  8. Characterization of Germ-Line Events in an X-Chromosome Duplication in Drosophila Melanogaster

    Kucherlapati, Raju SuryanarayanaUniversity of Illinois at Urbana-Champaign2014

    Made available in DSpace on 2014-12-12T00:51:24Z (GMT). No. of bitstreams: 1 7309973.pdf: 2983929 bytes, checksum: a8d8c6bf729fb93c6e8ea7be31bcdbfa (MD5) Previous issue date: 1972

    uiuc Repository record

  9. Palindromes on the human X chromosome : testis-biased transcription, gene conversion and evolution

    Saionz, Jennifer R., 1976-Massachusetts Institute of Technology2005

    Recent genomic studies of the Y chromosome revealed massive, testis-specific palindromes that span 30% of the chromosome and are subject to gene conversion. We conducted studies to determine whether similar palindromes exist on the human X chromosome and, if they exist, to what degree they share …

    mit Repository record

  10. Investigation Of X Chromosome Recognition: The Role Of Small Rna In Drosophila Dosage Compensation

    Menon, Debashish Unnikrishnan2013

    <p>In humans and flies, females have two X chromosomes but males have one X chromosome and one Y chromosome. This leads to a fatal imbalance in X-linked gene expression in one sex. In mammals and in the fruit fly <i>Drosophila</i>, modulation of X chromosome expression is critical for survival. …

    wayne-thes Repository record

  11. Nature and Sensitivity of Breaksites in a Long Duplication in the X-Chromosome of Drosophila Melanogaster

    Subbarao, Sarala KarumuriUniversity of Illinois at Urbana-Champaign2014

    Made available in DSpace on 2014-12-12T00:51:24Z (GMT). No. of bitstreams: 1 7405712.pdf: 3200307 bytes, checksum: bb27933a8031eec627252632c38eddf4 (MD5) Previous issue date: 1973

    uiuc Repository record

  12. Physical and genetical investigation of the Xp11.3 region on the short arm of the human X-chromosome

    Wittwer, Pia EthenaUniversity of the Western Cape2004

    … particular interest, since the mechanisms of X chromosome inactivation and the escape from inactivation are, as yet, not fully understood. The inactivation status of the DXS8237E and PCTKl gene differ: the first undergoes normal inactivation and the second escapes this process. The status of the …

    western-cape Repository record

  13. DNA Replication of the Male X Chromosome Is Influenced by the Dosage Compensation Complex in Drosophila melanogaster

    DeNapoli, Leyna2013

    … back to the genome. We found that the X chromosome of the male cell lines replicated earlier than the X chromosome in the female cell line or the autosomes. We were then able to compare the replication timing profiles to data sets for chromatin marks acquired through the modENCODE (model …

    duke Repository record

  14. A Genetic and Cytological Analysis of the Aberrant Behavior of an X-Chromosome Duplication in the Germ-Line of Drosophila Melanogaster

    Montgomery, Ilene Janet NowickiUniversity of Illinois at Urbana-Champaign2014

    Made available in DSpace on 2014-12-12T00:51:25Z (GMT). No. of bitstreams: 1 7412122.pdf: 5572086 bytes, checksum: 7e4ca20b493fd546949a7b630078c610 (MD5) Previous issue date: 1973

    uiuc Repository record

  15. Assessment of chromatin activity in mouse and human tissues

    Winter, Karen Judith.Brock University1985

    … and heterochromatic regions of mitotic chromosomes. This ill ~ technique has been used in this study to ask whether facultative heterochromatin of the inactive X chromosome can be distinguished from the active X chromosome in mouse and human tissues. In addition to this, in ~ nick …

    brock Repository record

  16. Studies on the mechanisms of action of the male specific lethal complex in Drosophila

    Sun, LinUniversity of Missouri--Columbia2011

    … by a twofold up-regulation of the single X chromosome in male Drosophila. The inverse dosage effect produced by the single dose of the X chromosome increases the expression of the X chromosome and autosomes. In order to equalize the autosomal expression in males and females, the MSL complex, …

    missouri Repository record

  17. Esx1 Dosage Impacts Reproductive Fitness: Effects On Viability and Fertility

    Fohn, Laurel E, <p>NOTE: This is not an Open Access dissertation. The item is placed here so that this note can be displayed. At the author's request, full text of this dissertation is only available via ProQuest Dissertations and Theses, in <em>print</em> format. The requester must pay a substantial fee for the printed copy.</p>2017

    … in placenta or testis localize to the X-chromosome. Both tissues undergo specialized X-chromosome inactivation (imprinted paternal inactivation in placenta and MSCI in testicular germ cells). When the X-chromosome is duplicated or improperly inactivated, defects in placentation, growth …

    uthsc Repository record

  18. Analisi molecolare in pazienti italiani con sindrome di Lowe

    CONGIU, RITAUniversità degli Studi di Cagliari2006

    … phenotype of Lowe syndrome in a female. The X chromosome inactivation studies detected an extremely skewed inactivation pattern with a ratio of 100:0 in the propositus as well as in five out of seven unaffected female relatives in four generations. The OCRL1 "de novo" mutation resides in the …

    cagliari Repository record

  19. The genetic basis of reproductive isolation in house mice: Studies of a European hybrid zone

    Payseur, Bret AllenThe University of Arizona.2003

    … reproductive isolation are biased toward the X chromosome. These observations suggest that reproductive barriers between young species are frequently due to disrupted interactions involving genes on the X chromosome. This idea motivates a detailed study of introgression for X-linked loci across …

    arizona-thes Repository record

  20. Efeito do cromossomo x no mapeamento de regiões genômicas sobre características de interesse econômico em búfalos da raça murrah

    Santos, Maria Ribeiro AraújoUniversidade Federal da Bahia2023

    The X chromosome is the fifth largest chromosome in the buffalo genome, containing many genes that can influence the expression of economically important traits. However, in current GWAS studies, researchers almost exclusively use molecular markers from autosomes, excluding the sex chromosomes. …

    brazil-ufba Repository record

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