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Showing 1 to 20 of 25 for “"Wt1"”.
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The role of Wt1 in Müllerian duct development
<p>WT1 is a zinc finger transcription factor widely expressed in the urogenital system. Human mutations of <em>WT1</em> lead to pediatric nephroblastoma as well as frequent differences of sex development (DSDs). Previous studies have suggested that WT1 acts as an activator for <em>Amhr2</em>, a …
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Prkca: Identification of A Novel Downstream Target of Wt1
… In 20% of Wilms tumors, Wilms tumor gene 1 (<em>WT1</em>) undergoes inactivating homozygous mutations causing loss of function of the zinc finger transcription factor it encodes. It is hypothesized that mutations in <em>WT1</em> result in dysregulation of downstream target genes, leading to …
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WILMS’ TUMOUR GENE 1 PROTEIN (WT1) – AN EFFECTOR IN LEUKEMOGENESIS?
Wilms’ tumour gene 1 (WT1) encodes a zinc-finger transcription factor functioning as a key regulator in organ development. WT1 was first identified as a tumour suppressor gene due to its inactivation in Wilms’ tumour cases, a childhood kidney cancer. In adult tissues WT1 expression is restricted to …
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Dysregulation of Meox2 Following Wt1 Mutation In Kidney Development and Wilms Tumorigenesis
… in tumorigenesis. The Wilms tumor gene 1 (<em>WT1</em>) is a transcriptional factor and one of the few genes known to have genetic alterations in WT and has been shown be inactivated in 20% of WTs. However, the mechanisms of how <em>WT1 </em>mutations lead to Wilms tumorigenesis and its …
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Regulatory dynamics of transcription factors TBX18 and WT1 in mouse prostate development
… of the zinc-finger transcription factor Wt1, a gene previously unreported to be expressed in the prostate and a known interaction partner of Tbx18. Furthermore, Wt1 was significantly dysregulated in Tbx18-/- mutant UGS indicating a relationship between the two genes in this tissue. After …
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The Wilms' tumor gene 1 (WT1) and leukemia -new insights and further complexity
The Wilms tumor gene 1 (WT1) encodes a zinc-finger containing transcription factor which is highly expressed in immature hematopoietic progenitor cells. A high expression of WT1 and the presence of somatic mutations in acute leukemia indicate a role for WT1 in the pathogenesis of leukemia. The …
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Mutationsanalyse der Gene NPHS2 und WT1 bei Patienten mit steroidresistentem Nephrotischen Syndrom im Kindesalter
… Syndrom im Kindesalter verursacht, ist WT1 auf Chromosom 11p13. Heterozygote Keimbahn-Mutationen in den Exonen 8 und 9 bzw. der Spleißstelle im Intron 9 dieses Gens führen zum Auftreten bestimmter Syndrome, wie dem Denys-Drash- oder Frasier-Syndrom. Es wurden jedoch auch Mutationen bei …
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Involvement of the WT1 and p16 genes in Wilms' tumour and human malignant mesothelioma
… processes. I have studied two such genes, the WT1 and p16 genes, which in their wild type forms are known to contribute to development of the urogenital system and the mesothelium (WTI) and to control of the cell cycle (pi6).
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The role of Wilms’ Tumor gene product (WT1)in CD95-mediated apoptosis in T-cell leukaemias
… promoter and activate it. Wilms’ tumor gene 1 (WT1) encodes a four-zinc-finger protein. Alternative splicing at the pre-mRNA level yields several transcript variants, of which the best characterized are the so called WT1-KTS and WT1+KTS isoforms. The WT1-KTS isoform, which lacks three amino …
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THE EFFECT OF SILENCING THE WILMS' TUMOR 1 GENE ON THE RADIATION SENSITIVITY OF GLIOBLASTOMA CELLS
… an oncogenic function. Moreover, known WT1 target genes have been implicated in resistance to radiation. To determine the role of WT1 in radiation resistance, two glioblastoma cell lines expressing WT1 were treated with siRNAs to silence this gene. Confirmation of WT1 knockdown was …
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A four-and-a-half LIM protein FHL2 acts as a coactivator for the Wilms' tumor suppressor WT1 during gonadal differentiation
… substance (MIS). The Wilms' tumor suppressor (WT1) and the orphan nuclear receptor steroidogenic factor 1 (SF-1) bind cooperatively to the promoter of MIS and activate its transcription. In the ovary, on the other hand, the orphan nuclear receptor DAX-1 binds to SF-1. The binding inhibits …
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Impact of Differentiation Status of Kidney Progenitors In Wilms Tumor Development
… introduce mutations of Wilms Tumor gene 1 (<em>Wt1</em>) or <em>b</em><em>-catenin</em> into fetal kidney cells in a progenitor-specific manner. We found that the nephron progenitors but not the stroma progenitors were able to give rise to Wilms tumors and that the different types of mutations …
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Mutationsanalyse der verantwortlichen Gene NPHS2 und Wilms-Tumor-Suppressorgen beim Nephrotischen Syndrom
… Podocin kodiert. Das Wilms-Tumor-Suppressorgen WT1 konnte als ein weiteres Gen identifiziert werden, das ebenfalls ein NS im Kindesalter verursacht. Es liegt auf Choromosom 11p13. Heterozygote Keimbahn-Mutationen in den Exonen 8 und 9 können ursächlich für die Entstehung eines NS sein. Hierbei …
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CYCLIN D1 AND WILMS TUMOR TRANSCRIPTION FACTOR-1 (WT1): POTENTIAL DIAGNOSTIC AND THERAPEUTIC MARKERS IN SMALL ROUND BLUE CELL TUMORS OF CHILDHOOD
Wilms tumor 1 (WT1) gene, firstly cloned in 1990 in the childhood kidney cancer Wilms tumor, is a gene located on chromosome 11p13, which encodes zinc-fingers protein characterized by multiple alternative isoforms, with important regulatory functions in cell growth and development. The protein …
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Cardiac repair post-myocardial infarction: Roles of the primary cilium and the long non-coding RNA Malat1
… repair. The transcription factor Wilms’ tumor 1 (Wt1) and the primary cilium regulate EMT. Furthermore, the long non-coding RNA (lncRNA) Malat1 is not only known to regulate EMT, but also mitigates cell death from injury. Little is known about the roles of Wt1, primary cilia, and Malat1 in …
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Markers immunoistochimici delle cellule staminali/progenitrici nel rene umano in via di sviluppo.
… cells were EMA (MUC1)+, CD15+, vimentin+, Wt1+, CD10+, Bcl2+, Wnt1+ and PAX2+; interstitial progenitor cells were Vimentin+, Wt1+ and α1Anti-tripsin +. Our data evidence the existence of multiple stem/progenitor cell pools in the fetal and neonatal human kidney. Progenitors of these …
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Comparación de perfiles de metilación de genes supresores tumorales en distintos subgrupos de tumores vesicales no músculo-invasivos
… tiempo libre de enfermedad para PAX5 (p=0.016), WT1 (p=0.036) y BRCA1 (p=0.023) en TaBG, para VHL (p=0.034), PAX6 (p=0.043), ATM (p=0.009), CHFR (p=0.049) y RB1 (p=0.013) para T1BG y para PYCARD (p=0.027) en T1AG. En el análisis multivariado, se obtuvieron como factores independientes de recidiva …
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The Expression and Function of Wilms' Tumor 1 in Malignant Glioma
… and glioma tissue specimens of all grades for WT1 expression. The majority of cell lines and 80% of all glioma tissue expressed WTI mRNA, all of which expressed WTl(+KTS) isoforms. Further screening of the glioblastoma specimens for p53 mutation followed by logistic regression analysis …
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BNC1 Regulates Human Epicardial Heterogeneity and Function
… distinct hPSC-epi subpopulations: one high in WT1 expression, the other high in TCF21. Bioinformatic analyses identified BNC1 as a potential key node in the hPSC-epi signalling network, via network inference modelling. BNC1 is a transcription factor known to regulate migration and proliferation …
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