Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 506 for “"Wound Healing"”.
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Corneal Wound Healing: Cells and Molecules
… deliver important growth factors that promote wound healing, resolution of the inflammatory response (i.e., PMN clearance) is also needed to restore corneal homeostasis. This dissertation evaluated mechanisms regulating platelet recruitment after corneal injury, PMN migration in the abraded …
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hyaluronic acid networks in wound healing
… the mechanisms underlying incomplete or abnormal healing are poorly understood. Diseases that hinder regeneration in humans often involve an abnormal accumulation of extracellular matrix (ECM)–a network of molecules occupying the space outside of cells. Beyond structural support, the ECM plays a …
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Role Of Gravin In Endothelial Wound Healing
… on EC migration was determined in a scratch wound and a 96-well based cell migration assay using antisense oligonucleotide and siRNA treatments. The </p> <p>effect of antisense oligonucleotide and siRNA treatments on gravin expression was assessed by Western blotting and cell based ELISA. …
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Developing platforms to investigate mechanotransduction during wound healing
Wound healing in adult skin tissue lacks the ability to recapitulate uninjured tissue structure-function, forming instead fibrotic tissue with limited functionality. The extracellular matrix regulates forces on a cell- and tissue-specific level. Fibronectin, a mechanically regulated extracellular …
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Antibiotic-free antibacterial hydrogels for wound healing applications
… cellulose (BC) has attracted great interest as a wound dressing thanks to its innate hydrogel-like structure and high biocompatibility. However, the lack of antibacterial features of cellulose poses some limitations to its use, especially in the context of increasing antimicrobial resistance. In …
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Functional Heterogeneity of Fibroblasts In Dermal Wound Healing
<p>Impaired wound healing can lead to excessive scarring, dehiscence, chronic ulcers, and infection, which have adverse impact on the quality of life and pose a significant economic burden on the health care system. Thus, new therapeutic approaches are critically important. Dermal fibroblasts are …
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Developing research, practice and education in wound healing
… my original contribution to the specialty of wound healing as it has evolved over the past twenty years. It comprises three projects through which I present and illustrate a selection of the work I have carried out as a researcher, clinician and educator in wound healing, and the relationship …
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Oleanolic Acid Improves Different Aspects of Wound Healing
Entre los compuestos naturales bioactivos, los triterpenoides pentacíclicos son conocidos por sus efectos farmacológicos y gran versatilidad, entre los cuales, el ácido oleanólico (AO), es conocido por sus propiedades antitumorales, antiinflamatorias, antioxidantes o hepatoprotectoras. La …
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The Impact of Psychological Interventions on Wound Healing
Wound healing is a complex biological process consisting of a number of overlapping phases. Research to date has found that psychological factors such as chronic stress and negative affective states can slow the wound healing process. The implications of these findings indicate that psychological …
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The Use of Amnion in Equine Wound Healing
… efficacy of lyophilized milled human amnion as a wound dressing of experimentally created equine distal limb wounds. Animals: Four clinically normal adult horses (3 Thoroughbred and 1 Paint, median age 11 years) obtained via donation. Procedures: One forelimb of each horse was randomly assigned to …
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Modulation of Inflammation Driven Wound Healing after Glaucoma Surgery
Dysregulated wound healing contributes to most currently unanswered ophthalmological morbidity. Opacification and structure altering contractures compromise the delicate ocular anatomy upon which ocular function and healthy vision are reliant. Glaucoma filtration surgery, corneal stromal injury, …
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Calcitonin Gene-Related Peptide Promotes Wound Healing of Cornea
Corneal wounds represent the most common type of ocular injury. Injuries to the corneal tissues can result in significant damage with loss of epithelial tissue and nerve fibers, causing a delay in healing time and ultimately problems with vision. Sensory neurons located throughout the cornea exert …
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Electromagnetic stimulation of a composite scaffold for wound healing
… been explored as an adjunct therapy for chronic wounds due to clinical evidence of wound healing enhancement. This dissertation investigated the incorporation of all three in the design and evaluation of an electromagnetically-stimulated composite scaffold comprised of decellularized porcine …
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Fibronectin splice isoforms in wound healing and vascular development
… of the alternatively spliced isoforms in wound healing and vascular development. Our results indicate that the bacterially expressed fibronectins are fully functional and promote a number of well-established fibronectin functions. Therefore, these fusion proteins should be useful for …
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Immunomodulatory biomaterials to promote early transplant integration and wound healing
… and graft loss. Despite these advances, wound complications due to systemic immunosuppression are a common post-transplant surgical complication. Therefore, there is a need for therapies that have the ability to allow for wound healing while also preventing rejection without the …
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Effects of light-emitting diode photostimulation on burn wound healing
… United States require medical care for burns. Healing of deep burn wounds requires restored perfusion and neoangiogenesis to reestablish blood flow and limit ischemic damage.\r\nWe propose that LED photostimulation, by inducing macrophage proliferation and secretion of pro-angiogenic factors, …
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Molecular Control of the Migratory Phase During Cutaneous Wound Healing
… complications that arise through delayed healing or as a consequence of the skins protective barrier being breached. The migration of cutaneous cells across a wound site is a crucial factor in establishing permanent restoration of the skins integrity. This study provides insight into …
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Nanofiber-based therapy for diabetic wound healing: a mechanistic study
Chronic diabetic wounds are a serious complication of diabetes mellitus, representing more than 27% of total annual diabetic health care costs which exceed $116 billion annually in the US alone. Diminished infiltration of new blood vessels (neovascularization) into the wound is a major factor …
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Gene therapy in a new model of delayed wound healing
Diabetes wounds result in significant morbidity, prolonged hospitalization and huge health care expenses. As of yet, no optimal animal models of diabetic wound healing exist to study potential beneficial therapies. Porcine wound healing is very similar to human wound healing. We stipulated that by …
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