Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"Wntless"”.
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Molecular Characterization of Early Dedifferentiation in Newt Forelimb Regeneration
… of a subset of these genes [β-catenin, wntless, dapper, thymosin-β 4 (Tβ4), and thymosin-β 10/15 (Tβ10/15)] in regenerating limb and tail tissue, as well as in differentiating newt myoblasts. We also verified the expression of these genes in the regenerating newt limb using …
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teashirt is required for head-versus-tail regeneration polarity in planarians
… genes [beta]-catenin-1, wntl, Dvl-1/2, or wntless. teashirt was required for [beta]-catenin-I-dependent activation of posterior genes during regeneration. These findings identify teashirt as a transcriptional target of Wnt signaling required for Wnt-mediated specification of posterior …
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Regulation of Wingless secretion, distribution and signaling
… Furthermore, I investigated the process of Wntless (Wls) trafficking and its role in Wingless secretion. I found that Wls undergoes ubiquitination on the cell surface. Importantly, from a genetic RNAi screen, I identified two essential components in the control of Wls ubiquitiation, the E3 …
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Mechanisms of Genome Buffering and Cell Fate Coordination in Adult Tissue Homeostasis
… stereoselectivity of the Wnt chaperone Wntless (WLS) for fatty acids. My findings provide a mechanistic account of chemical specificity observed in Porcn inhibitors, and delineate a universal mechanism for integrating communal cell fate decision-making with metabolic fitness. As part of …