Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 21 for “"Wnt5a"”.
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Role of Wnt5a in Prostate Cancer
Wnt5a is a non-canonical secreted glycoprotein of the Wnt family that plays important roles in organ development and tissue orientation. Previous studies have reported that Wnt5a was upregulated at both mRNA and protein levels in prostate cancer, but information regarding its role in predicting …
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Untersuchungen zur Rolle von Wnt5a beim Basalzellkarzinom
… Ptch zurückzuführen ist. Daneben scheint auch Wnt5a eine Rolle bei diesem Tumor zu spielen, da eine Überexpression dieses Gens beim BCC beschrieben worden ist. Ziel dieser Arbeit war es, eine mögliche Regulation von Wnt5a durch die Hh/Ptch-Signalkaskade, den Effekt von Wnt5a auf Keratinozyten …
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Understanding and Exploiting Wnt5a and GSK3 Signaling in Inflammatory Disease
… atherosclerotic plaque has been well documented. Wnt5a, a secreted glycoprotein, is highly present in atherosclerotic lesions, and is known to be upregulated in other inflammatory diseases like rheumatoid arthritis and sepsis. Interleukin-6 (IL-6), an inflammatory cytokine secreted by activated …
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The impact of Wnt5a signaling and tumor associated macrophages in breast cancer
… cancer is secondary tumors. Downregulation of Wnt5a in primary ductal breast cancer has been correlated with poor outcome and higher tumor grade and found to be an independent predictor of recurrence. The ability of Wnt5a to inhibit tumor progression can partly be explained by Wnt5a induced …
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Fgf4 and Wnt5a/Pcp Signaling Promote Limb Outgrowth by Polarizing Limb Mesenchyme
… mesoderm, we established that FGF activates Wnt5a in a gradient fashion. Once it was established that Wnt5a was expressed at the right time and place to turn on PCP signaling, we investigated the ability of Wnt5a to influence cell migration and/or cell polarity. Our analysis revealed that …
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Macrophage Polarization (M1/M2) and its Role in Wnt5a Secretion/Expression in Atherosclerosis
… atherosclerotic lesions has been suggested. Wnt5a is a noncanonical member of the wingless family of proteins that is expressed in human macrophages in different inflammatory diseases including atherosclerosis. These observations led us to hypothesize that Wnt5a secretion/expression is …
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Veränderungen der Morphologie und des Migrationsverhaltens unter dem Einfluss von Wnt5a und DKK-1 bei Brustkrebszellen
… in Vorarbeiten bereits gezeigt werden, dass Wnt5a die Invasivität der wenig invasiven Brustkrebszelllinie MCF-7 über den nicht-kanonischen Signalweg via Jun-N-terminale Kinase (JNK) steigert. Die im Rahmen dieser Arbeit durchgeführte Analyse der morphologischen Veränderungen mittels …
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The Role of The Hypoxia-Inducible Factor 2 In Pancreatic Cancer: Mechanisms of Tumor Immunosuppression and Intestinal Radioprotection
… HIF2 in SI organoids and found that <em>Wnt5a </em>was among the top upregulated transcripts. Luciferase reporter assays showed that HIF2 directly activates the <em>WNT5A </em>promoter via a hypoxia response element. Furthermore, through knockout and rescue experiments, we found that …
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Immunosuppressive Myeloid Cells in Breast Cancer and Sepsis
… In this thesis we identified a factor (Wnt5a) that may be involved in skewing immune responses towards immunosuppressive, tumor promoting immune cell populations. In a pro-inflammatory setting (i.e. in the presence of exogenous pathogen-associated molecular patterns; PAMPs, or endogenous …
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Regulation of chondroprogenitor cell gene expression and migration
… - a disease of articular cartilage. The role of WNT5A signalling was then investigated (which is up-regulated in osteoarthritic cartilage) in a disease-like context by stimulating cultures with cytokines. Microarray analysis unearthed interesting and novel results, including a decrease in WNT5A …
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Genistein suppresses colon cancer metastasis through epigenetic regulations
… addition to NDRG1, dramatic down-regulation of Wnt5a, one of the WNT signaling factors, was also found in SW620 compared to SW480. Wnt5a expression was not responsive to DNA methyltransferase inhibitor 5-aza-cytidine treatment. However, histone deacetylase (HDAC) inhibitors trichostatin A (TSA) …
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Epigenetic modifications on WNT genes by dietary genistein during colon cancer development
… the expression of WNT signaling genes including Wnt5a, Sfrp1, Sfrp2, and Sfrp5 to the similar level to that of pre-AOM period. Rats fed SPI and GEN had a decreased number of total aberrant crypts. GEN feeding also resulted in a reduced number of ACF with N=3 per foci. The reduction of …
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Role of Wnt signaling in proliferation of human bone marrow-derived mesenchymal stem cells
… we found that the expression levels of Wnt5a and retinoic-acid orphan related receptor α were gradually increased with passage. These observations suggest that non-canonical Wnt pathway is a potent regulator of hMSC proliferation.
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FUNCTIONAL CHARACTERIZATION OF DENND5A/RAB6IP1 IN EARLY EMBRYONIC DEVELOPMENT
… and within punctate structures, however, Wnt5a and Wnt3a stimulations don't appear to affect their subcellular colocalization. In Xenopus in-vivo experiments, knockdown of Dennd5a by morpholino leads to unclosed blastopore and “open-back” defect during embryonic development. Interestingly, …
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Genomic Profiling of Alternative splicing in liver cancer
… pathway. Especially, alternative splicing of WNT5A gene depending on HCC subtype was found, which may reflect the recurrence and progression. This study supposed that using classification based on the profile of alternative splicing of HCCs can reveal subtypes with distinct clinicopathologic …
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Molecular Control of the Migratory Phase During Cutaneous Wound Healing
… that initiation of autophagy is responsive to Wnt5a signals secreted by several cell types within the wound site and these signals must pass through Frizzled 3 receptors and Rho-associated protein kinase to activate nucleation of phagophore membranes. This study also develops and tests the use …
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Der Wnt-Signalweg in der Makrophagen-induzierten Invasion von Brustkrebszellen
… Wnt abhängiger Faktor identifiziert werden. Wnt5a stellt somit einen zentralen Regulator der Makrophagen-induzierten Invasion dar. Dies betrifft sowohl die proteolytische Aktivität der Makrophagen als auch die Invasionssteigerung der Tumorzellen.
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Biomarkers in sepsis and other severe infections
… and septic shock. We identified a protein (Wnt5a) that inhibited differentiation of monocytes to monocyte-derived myeloid dendritic cells (Mo-mDC), which may play a role in the DC depletion often seen in sepsis. Also, as indicated by cell surface phenotype, a large inter-individual variation …
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Neurodegeneration und Neuroprotektion bei der Parkinson-Krankheit: Untersuchungen von β-Carbolinen und dem Dopaminagonisten Lisurid in der dopaminergen mesencephalen Primärzellkultur des Mausstammes C57Bl/6
… Spektrum neurotropher Faktoren (Shh, Wnt1, Wnt5a) und Transkriptionsfaktoren (En1, Nurr1, Pitx3), die für die Differenzierung und Entwicklung DA Neurone entscheidend sind, durch die Behandlung mit 9-Me-BC hochreguliert. Zusätzlich erhöhte sich die Expression der DA Markergene Aldh1a1, Dat …
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