Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 14 of 14 for “"Wnt-pathways."”.
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The Localization of β-catenin During Xenopus Kidney Development: A Look into β-catenin's Role in Kidney Development
<p>Wnt signaling is a conserved cell communication system that drives embryonic development. Wnt pathways regulate a variety of developmental processes, including cell migration, proliferation, and fate determination. Dysregulation of Wnt signaling can lead to developmental disorders and diseases. …
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Functional Genomics Based Interrogation of Cell-Fate Determination Pathways
The Hedgehog (Hh) and Wnt signal transduction pathways are master regulators of embryogenesis and tissue renewal and represent anticancer therapeutic targets. Using genome-wide RNA interference screening in murine cultured cells, I established previously unknown associations between these signaling …
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Regulatory Architecture of Non-Apoptotic Cell Death Program in C. Elegans
… demonstrated that two opposing spatial cues, the Wnt ligands EGL-20 and LIN-44, cooperate with LIN-29 to control linker cell death initiation. I showed that the Abdominal- B-like Hox transcription factor NOB-1 likely acts upstream of these two Wnt pathways, and that the Tailless/Tlx nuclear …
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Notchless Interacts with Multiple Signaling Pathways during Mouse Peri-Implantation Development
… to the embryo that disrupts multiple signaling pathways during peri-implantation development. I present data that: 1. Refute the presumption that Nle1 functions as a negative regulator of NOTCH during pre-implantation development; 2. Demonstrate that mutations in Nle1 lead to mis-expression of …
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Selecting dietary-derived bioactives which protect cartilage from destruction in osteoarthritis
… or isoliquiritigenin pretreatment on three pathways implicated in OA, the NFκB, TGFβ and Wnt pathways was analysed. Apigenin and isoliquiritigenin showed differences in the patterns of inhibition in the NFκB and TGFβ pathways. The Human Phospho-Kinase Array Kit was used to perform an …
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The use of massively parallel sequencing to study the virome, epigenome and genome of canine and feline cancers
… and neurogenic/neuroendocrine, HOX and Wnt pathways were epigenetically targeted. In canin osteosarcoma (OSA) we built upon the genome model by adding loss of heterozygosity data and illustration of metastatic lesions. We also provided support to target the CDK4, Wnt and mTOR pathways. …
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Multiomic Analyses Reveal Epigenomic Alterations and New Targets of Polycomb Repressive Complex 2 in Schwann Lineage Cells and Malignant Peripheral Nerve Sheath Tumors
… subsets are defined by enrichment of SHH and Wnt pathways. These pathways can also be therapeutically targeted with small-molecule inhibitors. The second objective focused on the role of PRC2 in gene repression, crucial for cell identity and malignant transformation. The phenotypic …
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The Role of Acidic Fibroblast Growth Factor and Fibroblast Growth Factor Receptor 4 In High Grade Serous Carcinoma
… were quantified. To identify relevant cellular pathways involved, responsive cell lines were transduced with different transcription response elements using the Cignal-Lenti reporter system and treated with FGF1 with and without transient FGFR4 knock down. This was followed by western blot …
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Investigating WNT signalling in the lung
… oligohydramnios. As a branch of non-canonical WNT signalling, the planar cell polarity (PCP) pathway has emerged as a key ciliary signalling mechanism. Recent studies have highlighted the involvement of core PCP proteins in both ARPKD pathology and lung development and homeostasis. The aim of …
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Examining swim bladder inflation failure as a toxicological endpoint in Japanese medaka (Oryzias latipes)
… signaling inhibitor, as well as 1 μM IWR-1, a Wnt signalling inhibitor, resulted in >95% inhibition of swim bladder inflation of Japanese medaka larvae. The effects of these inhibitors on the expression of medaka genes related to the Hh and Wnt pathways, as well as genes involved in the …
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DEVELOPMENT OF THE LARVAL PERIPHERAL NERVOUS SYSTEM IN THE ASCIDIAN CIONA INTESTINALIS: ROLE OF THE RETINOIC ACID AND FGF/WNT SIGNALLING PATHWAYS AND OF THE POU TRANSCRIPTION FACTORS.
… between Retinoic Acid (RA) and the FGF/WNT pathways control its development; b) to study the role played by transcription factors of the POU family in its differentiation. Within chordates, tunicates represent the sister group of vertebrates and their larvae have a typical chordate body …
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Mechanisms Regulating The P120-Catenin/Kaiso Pathway
<p> <p> The Wnt pathways contribute to many processes in cancer and developmental biology, with β-catenin being a key canonical component. P120-catenin, which is structurally similar to β-catenin, regulates the expression of certain Wnt target genes, relieving repression conferred by the POZ/ …
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Novel intracellular signalling regulators of cartilage progenitor cell populations
… were studied. DACT1 and DACT2 are known to be Wnt and TGFβ pathways regulators, but their role in chondrocytes and MSCs has not been described before. Both proteins are present in chondrocytes throughout the osteoarthritic human tissue, including in chondrocytes forming cell clusters. On the …
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Untersuchungen zur Rolle von Wnt5a beim Basalzellkarzinom
… Ptch zurückzuführen ist. Daneben scheint auch Wnt5a eine Rolle bei diesem Tumor zu spielen, da eine Überexpression dieses Gens beim BCC beschrieben worden ist. Ziel dieser Arbeit war es, eine mögliche Regulation von Wnt5a durch die Hh/Ptch-Signalkaskade, den Effekt von Wnt5a auf Keratinozyten …