Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"Wnt-5a"”.
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Wnt-5a signaling in breast cancer metastasis
… breast cancer patients. It has been shown that Wnt-5a plays an important role in breast cancer, since loss of that protein is associated with a higher frequency of metastasis. The findings presented in this thesis show that Wnt-5a inhibits the metastatic behaviour of breast cancer cells by …
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Role of DARPP-32 in Breast Cancer Cell Signalling and Migration
… of breast cancer metastasis. Low expression of Wnt-5a in a primary breast tumor is associated with shorter recurrence free survival, suggesting that Wnt-5a acts to restrict breast cancer metastasis. Moreover, Wnt-5a is known to inhibit migration of breast epithelial cells in culture and …
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Der Wnt-Signalweg in der Makrophagen-induzierten Invasion von Brustkrebszellen
… Aspekt der Tumorbiologie dar. Die Familie der Wnt-Signalproteine ist ein potentieller Mittler dieser Kommunikation. Anhand des Expressionsmusters von Wnt-Rezeptoren, -Liganden und Zielgenen konnte ein Wnt-sensitiver Phänotyp in Tumorzellen und Makrophagen identifiziert werden. Die Ko Kultur von …
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Mikroglia fördert die Invasivität von Karzinomzellen
… konnte diese Arbeitsgruppe die Bedeutung des Wnt-Signalwegs für die Makrophagen-vermittelte Steigerung der Tumorinvasivität anhand der Hochregulation von Wnt 5a in kokultivierten Makrophagen nachweisen. Im Rahmen der vorliegenden Arbeit wurden die Interaktionen zwischen der sessilen …
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Wnt Secretion Proteins Modulate RANKL-Induced Expression of Aire in Thymic Epithelial Cells
… In the thymus, TECs differentially express Wnt proteins, which activate canonical and non-canonical Wnt signaling pathways. Wnt signaling is thought to regulate cell survival, proliferation, and development although the direct molecular mechanisms in TECs have yet to be elucidated. The …
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Immunohistochemical Evaluation and Gene Expression Profiling of Senile Lentigo
… SFRP2 (secreted frizzled-related protein 2), Wnt-5a, p16 and p53 and computer-assisted image analysis were performed. DNA microarray analysis was carried in one female volunteer with both lentigo and melasma. RESULTS: Histological features of senile lentigo of the face were characterized by …