Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 94 for “"Wnt signalling"”.
-
Investigating WNT signalling in the lung
… oligohydramnios. As a branch of non-canonical WNT signalling, the planar cell polarity (PCP) pathway has emerged as a key ciliary signalling mechanism. Recent studies have highlighted the involvement of core PCP proteins in both ARPKD pathology and lung development and homeostasis. The aim of …
-
WNT signalling in the patterning of human gastruloids
… and leads to the formation of the body plan. WNT signalling, an evolutionary conserved pathway, is known to play a crucial role during gastrulation with its dysregulation leading to various developmental abnormalities and diseases. This thesis examines the role of WNT signalling in the …
-
The role of Wnt signalling during embryonic salivary gland development
… spreads distally. We looked at the function of Wnt signaling during embryonic development of the submandibular and sublingual salivary glands and found that FGF signaling acts upstream of Wnt signaling and that Wnt and FGF signals coordinate branching morphogenesis and lumen formation. To locate …
-
Function of the PDLIM2 protein in oncogenic Wnt signalling pathways
Aberrant regulation of the Wnt signalling pathway is a recurrent theme in cancer biology. Hyper activation due to oncogenic mutations and paracrine activity has been found in both colon cancer and breast cancer, and continues to evolve as a central mechanism in oncogenesis. PDLIM2, a cytoskeletal …
-
Regulation of Wnt signalling pathways by the Dishevelled DEP domain
Wnt signals bind to Frizzled receptors to trigger canonical and noncanonical signalling responses that control cell fates during animal development and tissue homeostasis. All Wnt signals are relayed by the hub protein Dishevelled (DVL). During canonical (β-catenin dependent) signalling, …
-
Regulation of Wnt signalling in ovarian cancer and immune cells
Wnt signalling is an ancient, highly conserved, and tightly regulated pathway involved in embryogenesis, cell polarity, and migration. Dysregulation of Wnt signalling is associated with abnormal cellular growth contributing to cancer formation. Especially in colorectal cancer (CRC) mutations in the …
-
Investigating the Non-globular Proteins of the Canonical Wnt Signalling Pathway
The canonical Wnt pathway is a vitally important signalling pathway that plays an important role in cell proliferation, differentiation and fate decisions in embryonic development and in the maintenance of adult tissues. The twelve Armadillo (ARM) repeat-containing protein beta-catenin acts as the …
-
Exploring the role of Wnt signalling in heart failure with preserved ejection fraction.
… throughout the literature that Wingless/int1 (Wnt) signalling plays a role in the development of both cardiomyocyte hypertrophy and cardiac fibrosis, which are key features of HFpEF. Useful in vivo models of HFpEF are lacking; however, a recently-published 'two-hit' (metabolic and mechanical …
-
The WNT signalling pathway in Ewing sarcoma/primitive neuroectodermal tumour : an immunohistochemical investigation
The WNT pathway is a major developmental pathway that plays an important role in the development of many tumours, including neuroectodermal and bone tumours. Ewing sarcoma (ES) / primitive neuroectodermal tumour (PNET) shows varying degrees of neuroectodermal differentiation and is the second …
-
The role of stem cells and WNT signalling pathway in renal cell carcinoma
… markers (CD133 and CD105). To review the WNT signalling pathway in renal cell carcinomas using selected protein expression by immunohistochemistry (β-Catenin).Materials and methods: Ten-year retrospective study in which sixty-four cases of renal cell carcinoma were retrieved and reviewed. …
-
The Role and Control of WNT Signalling in an HESC Model of Human Primitive Streak
… streak (PS) and is largely controlled by WNT, BMP, and ACTIVIN/NODAL signalling. Despite detailed characterization in model organisms, the human PS and the role these pathways play in its formation and patterning remains a mystery. In this work I focused on understanding the role and …
-
Elucidating the biological function of the uncharacterised protein FAM83G/PAWS1: Role in Wnt signalling through its interaction with Caseine Kinase 1α
… of the SMAD1 transcription factor. Because BMP signalling plays a fundamental role during embryogenesis, collaboration with Jim Smith (The Francis Crick Institute, London) led to the discovery that ectopic expression of PAWS1 mRNA in Xenopus embryos leads to a complete duplication of body axis. …
-
Wnt Signals and Imaging Tissue Renewal in the Human Colonic Epithelium
… with all of its specialised cell lineages. Many signalling pathways are involved in the regulation of these activities, the predominant one being the canonical Wnt signalling pathway. The Wnt signalling pathway is known to be dysregulated in many cancers and has been posed as a potential …
-
DEVELOPMENT OF THE LARVAL PERIPHERAL NERVOUS SYSTEM IN THE ASCIDIAN CIONA INTESTINALIS: ROLE OF THE RETINOIC ACID AND FGF/WNT SIGNALLING PATHWAYS AND OF THE POU TRANSCRIPTION FACTORS.
… between Retinoic Acid (RA) and the FGF/WNT pathways control its development; b) to study the role played by transcription factors of the POU family in its differentiation. Within chordates, tunicates represent the sister group of vertebrates and their larvae have a typical chordate body …
-
Defining the minimal and context-dependent signalling cascades regulating the maintenance of human naïve embryonic stem cells and early embryo development
… epiblast lineage. Whilst some of the signalling cascades that are fundamentally implicated in modulating the naïve gene regulatory network have been studied, our understanding of the finer details is incomplete. To date, the roles of the WNT signalling cascade remains a topic of …
-
A study of Notch signalling in developmental angiogenesis
… tip cells, therefore suggesting a role of Notch signalling in its regulation. In the mouse, suppression of Notch signalling by pharmacological inhibition of γ-secretase or genetic deletion of one Dll4 allele resulted in excessive endothelial tip cell formation and a poorly-patterned, hyperdense …
-
Mechanisms of molecular switching in the Wnt signal transduction pathway
Wnt signalling is a critical cellular communication pathway controlling cell fate in all metazoan organisms. Timely activation of this pathway is crucial to coordinate development, control homeostasis of adult tissues, and to avoid cancer. Wnt signal transduction depends primarily on the activities …
-
An in vivo study of novel genetic modifiers in autosomal recessive polycystic kidney disease (ARPKD)
… genes localising to the primary cilium. Ciliary signalling pathways, such as Wnt signalling, have been investigated to dissect potential molecular mechanisms of ARPKD, however, these remain unclear. To overcome this, researchers have tried to develop rodent models that replicate human ARPKD and …
-
Beta-catenin Complexes in Colorectal Cancer
… of colorectal cancer cause defects in key signalling pathways that affect cell function. The Wnt signalling pathway is a key pathway that is disrupted in colorectal cancer and β-catenin is the key mediator of Wnt signalling. β-catenin is a multifunctional protein with roles in Wnt …
Page 1 of 5