Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 43 for “"Wnt signaling pathway"”.
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The canonical Wnt signaling pathway affects regeneration of mechanosensory hair cells in Danio Rerio
… Research using pharmacological modulators of the Wnt pathway has suggested that the Wnt pathway potentially plays a role in lateral line hair cell regeneration. In this current study, we examine the role of the Wnt signaling pathway in hair cell regeneration by employing Wnt pathway mutant …
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Regulation of Dkk1, an Inhibitor of the Wnt Signaling Pathway, by DAX-1 in Mouse Embryonic Stem Cells
<p>DAX-1 is known to play a key role in the maintenance of pluripotency in mouse embryonic stem cells (mESC), such that elimination of DAX-1 (through methods such as RNAi) leads to the differentiation of ESC (Khalfallah et al. 2009). Earlier research by the Tzagarakis-Foster lab identified target …
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Characterization of Dishevelled Associated Activator of Morphogenesis 2 (Daam2) in Wnt Signaling During Early Embryonic Development
The Wnt signaling pathway is highly conserved in metazoan animals. Wnt signaling regulates an array of cellular processes that include motility, polarity, cell fate determination, primary axis formation and organogenesis and recently have been implicated in stem cell renewal. Deregulated Wnt …
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Identifying Genes in Pancreatic Beta-Cell Function using a Novel High-Thoughput Cell-Based Screening Assay
… (IRASFS) positional candidate genes and the Wnt signaling pathway components, where the genes with significant impacts on glucose-stimulated secretion were subject to further delineation. The IRASFS gene list was established through linkage analysis of quantitative trait loci for measures of …
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EBV BART MicroRNAs Target Pro-apoptotic and Anti-Wnt Signaling Genes to Promote Cell Survival and Proliferation
… miR-BARTs can inhibit apoptosis and activate the Wnt signaling pathway. To discover miR-BARTs that can inhibit apoptosis, I individually expressed miR-BARTs in the EBV- GaCa cell line AGS, and identified five miR-BARTs that conferred this phenotype. To identify pro-apoptotic genes targeted by the …
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Development of Vessels, Airways and Cartilage Rings: The role of T-box genes
… transcription factors Snai1 and Twist, and signaling molecules Bmp2, Bmp7, Notch2, Jag1 and Wnt2In addition, we show that the canonical Wnt signaling pathway contributes to the vessel-forming potential of the allantois. Ex vivo, the Tbx4 mutant phenotype can be rescued using agonists of the …
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Mathematical modeling of pathways involved in cell cycle regulation and differentiation
… yeast cell cycle (Chapter 1), and the canonical Wnt signaling pathway involved in cell proliferation and differentiation (Chapter 2). START transition is an important decision point where the cell commits to one round DNA replication followed by cell division. Several years of experimental …
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Structural Basis for Dishevelled-2 Association to the Plasma Membrane
The Wingless (Wnt) signaling pathway is one of the critical developmental pathways for control of cell differentiation, proliferation, and cell growth. The DEP domain, located on the C-terminus of Dishevelled (Dvl), plays a role in cytoplasm-membrane association, which branches the canonical and …
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DISSECTING THE ROLE OF Β-CATENIN AND MYC IN GASTRIC TUMOR FORMATION
… of distinct gene-expression programs. The Wnt signaling pathway plays a prominent role in regulating the homeostasis of gastrointestinal epithelium by promoting stem cell maintenance, proliferation and cell fate specification. Aberrant activation of the Wnt/β-catenin signaling pathway …
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The Role of Wnt Signaling in Bone Mechanotransduction
… and low bone mass. In skeletal tissue, canonical Wnt signaling is a critical regulator of bone mass, and dysregulation of the Wnt pathway has been implicated in numerous skeletal displasias. Some components of the Wnt signaling pathway have a clear role in bone homeostasis, particularly in the …
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The Molecular Mechanisms of Estrogen Receptor α on Two Single Nucleotide Polymorphisms to Regulate WNT Signaling in Osteoblasts
… estrogen deficiency, and dysregulation of the WNT signaling pathway contribute to the development of this disease. Genome-wide association studies have predicted that the single nucleotide polymorphisms (SNPs) rs2887571 and rs9921222 associate with low bone mass, but the mechanism of these SNPs …
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Tumor Suppressor APC and Musashi1: Double-Negative Feedback, Wnt Signaling and Colon Cancer
… transcriptional activation through the canonical Wnt signaling pathway. My work has demonstrated that APC mRNA is a target of MSI1 binding and translational repression. Further study has indicated that MSI1 binding also results in stabilization of the APC mRNA, presumably as a rapid response …
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Defining the molecular basis for the β-catenin and CDC73 interaction
… factors, including β-catenin, a component of the Wnt signaling pathway, are used to regulate gene expression in response to developmental or environmental cues. Previous studies reported that β-catenin binds to the central region of CDC73, a subunit of the Polymerase Associated Factor 1 complex …
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Casein Kinase I Transduces WNT Signals
Wnt signaling controls a diverse array of processes including cell growth, oncogenesis, and development. Components of the Wnt cascade are altered in several human cancers including colon cancers and melanomas. We set out to identify novel components of this signal transduction pathway via …
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The transcriptional regulation of skeletal muscle progenitor cell fate
… myogenesis. Chapter 3 demonstrates that the Wnt signaling pathway positively regulates the expression of Foxc1/2. This result was further extended by the demonstration that beta-catenin occupies the chromatin upstream of Foxc1 during differentiation. Loss of functional Gli2 and Meox1 led to …
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teashirt is required for head-versus-tail regeneration polarity in planarians
… specified to replace missing tissues. The Wnt signaling pathway serves a central role in specifying posterior cell fates during planarian regeneration. We identified a gene encoding a homolog of the Teashirt family of zinc finger proteins in the planarian Schmidtea mediterranea to be a …
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Targeting Kremen1 Downregulation with RVG-9R/siRNA Complexes in the Triple-Transgenic Mouse Model of Alzheimer’s Disease
… may be caused by the disruption of the canonical Wnt signaling pathway by Dickkopf-1 (Dkk-1). Under normal conditions, the canonical Wnt signaling pathway is responsible for normal neuronal development, synaptic plasticity, and overall normal brain function. Amyloid-[beta] (A[beta]) plaques and …
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The Role of Dax-1 in Regulating Pluripotency in mouse Embryonic Stem Cells
… including genes that are involved in the Wnt signaling pathway. In attempts to understand the mechanism of Dax-1 action in ES cells, we are investigating the effect of Dax-1 knockdown on the regulation and expression of the identified target genes. </p>
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Engineering Tools to Promote and Characterize Wnt-Mediated Stem Cell Differentiation
The Wnt signaling pathway plays an important role in the development of many tissues in the body from the earliest stage of the process. However, the mechanisms of the Wnt pathway and the roles it plays in development remain incompletely understood. This is in part due to the complexity of …
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Transcriptional Regulation of the Xenopus MyoD Gene
… Lef-1 is the transcription factor of the zygotic Wnt signaling pathway that activates the expression of the XmyoD gene.
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