Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 140 for “"Wnt signaling"”.
-
WNT SIGNALING AND HAIR FOLLICLE INITIATION
… cues for hair follicle initiation. Uniform Wnt signaling activity is present in dermal fibroblast precursors preceding hair follicle initiation, but the functional requirement of dermal Wnt signaling at early stages of skin differentiation and patterning remains largely uncharacterized. In …
-
Regulation of Neuronal Polarity by Wnt Signaling
Wnts are highly conserved secreted glycoproteins that function in many developmental processes. Cell surface receptors, including the Frizzleds (Fz), ROR, and RYK families of proteins, bind Wnts to activate a number of downstream pathways. Wnts act redundantly to regulate the anteroposterior …
-
The Role of Wnt Signaling in Bone Mechanotransduction
… and low bone mass. In skeletal tissue, canonical Wnt signaling is a critical regulator of bone mass, and dysregulation of the Wnt pathway has been implicated in numerous skeletal displasias. Some components of the Wnt signaling pathway have a clear role in bone homeostasis, particularly in the …
-
Dact Family Molecules In Wnt Signaling In Mouse Development
The Wnt: Wingless-Integration) molecular signaling pathways are known to be integral in the embryonic patterning of multicellular animals, and are misregulated in multiple types of cancer. Wnt signaling includes multiple biochemical signaling pathways downstream of the Wnt family of secreted …
-
RacGap50C Is a Novel Negative Regulator of Wnt Signaling
<p>The Wingless (Wg)/Wnt signal transduction pathway directs a variety of cell fate decisions in developing animal embryos. Despite the identification of many Wg pathway components to date, it is still not clear how these proteins work together to generate cellular identities. We have carried out a …
-
Converging roles of neurodevelopment and Wnt signaling in neuropsychiatric disorders
… disorder patients increasingly suggest that Wnt signaling and cortical development - in addition to other perturbations - may underlie the pathophysiology of multiple disorders. Furthermore, besides autism spectrum disorder, contribution of neurodevelopmental dysregulations to disease …
-
Proteomic Analysis of WNT Signaling and Metabolism of Fibrolamellar Hepatocellular Carcinoma
… cellular pathways. First, I investigate the role Wnt signaling plays in the pathogenesis of FLC. It has long been reported that canonical Wnt signaling may play a role based on the transcriptomic analysis, and synergistic mutagenesis screens. I will next utilize proteomics, imaging, and drug …
-
Feedback Regulation of Wnt Signaling by Naked Cuticle (Nkd) During Drosophila Embryogenesis
Wnt/beta -catenin signals are essential for many developmental and physiological processes in animals. Deregulation of the Wnt signaling pathway in mammals can cause diseases such as birth defects, cancer, osteoporosis, and diabetes. In Drosophila, the naked cuticle (nkd) gene antagonizes the …
-
Effects of Binge Alcohol Exposure on Canonical Wnt Signaling During Fracture Repair
… of all orthopaedic trauma cases. The canonical Wnt pathway, through tight regulation of stabilized beta-catenin, plays an essential and pivotal role in the formation of new bone and cartilage to initiate bone repair. We sought to determine the molecular mechanisms behind alcohol-related fracture …
-
Wnt signaling in zebrafish fin regeneration : chemical biology using a GSK3β inhibitor
… are due, at least in part, to modulation of the Wnt/β-catenin pathway. Activation of the Wnt/ β-catenin pathway using a small molecule inhibitor of GSK3β was previously shown to increase markers of bone formation in vitro. Our study utilized a zebrafish model system to study Wnt activated fin …
-
The Role of Wnt Signaling in Development of the Ophthalmic Trigeminal Placode.
… described. This study identifies the canonical Wnt signaling pathway as a regulator of opV trigeminal placode development. Introducing dominant-negative TCF and dominant-active β-catenin expression constructs by in ovo electroporation, we have manipulated the canonical Wnt pathway within the opV …
-
THE EFFECTS OF ESTROGENIC COMPOUNDS ON ADIPOGENESIS VIA PPARγ AND CANONICAL WNT SIGNALING
… potential interactions with PPARγs, canonical WNT proteins, and estrogen receptors (ER) signaling. The current investigation was conducted to test the effects of synthetic and natural estrogenic compounds (BDDA, daidzein, and genistein) for their effects on the induction of adipogenic …
-
Tumor Suppressor APC and Musashi1: Double-Negative Feedback, Wnt Signaling and Colon Cancer
… transcriptional activation through the canonical Wnt signaling pathway. My work has demonstrated that APC mRNA is a target of MSI1 binding and translational repression. Further study has indicated that MSI1 binding also results in stabilization of the APC mRNA, presumably as a rapid response …
-
Interactions between BMP and Canonical Wnt Signaling Regulate Critical Stages of the Osteoblast Lifecycle
… genetic and mechanistic information about other signaling pathways that can potently stimulate osteoblast differentiation and/or function. A wealth of genetic evidence in humans and mice clearly demonstrates that the canonical Wnt pathway is intimately involved in skeletal development and …
-
The Study of Wnt Signaling Effector POP-1/TCF in C. Elegans Early Embryos
In C. elegans embryos, the combined Wnt/MAPK pathway polarizes the founder cell of mesendoderm, EMS blastomere, such that EMS produces two daughters with distinct developmental fates. The posterior daughter E, whose fate is specified by Wnt/MAPK, generates intestinal tissues (endoderm), whereas the …
-
The canonical Wnt signaling pathway affects regeneration of mechanosensory hair cells in Danio Rerio
… Research using pharmacological modulators of the Wnt pathway has suggested that the Wnt pathway potentially plays a role in lateral line hair cell regeneration. In this current study, we examine the role of the Wnt signaling pathway in hair cell regeneration by employing Wnt pathway mutant …
-
Role of Wnt signaling in proliferation of human bone marrow-derived mesenchymal stem cells
… Wingless-related MMTV integration site (Wnt) is well known signaling molecules that implicated in mesenchymal differentiation during development, but the role in proliferation of hMSCs is not well known. In this study, we investigated the effect of Wnt signaling molecules on the …
-
The Effects of Tracheal Occlusion on Wnt Signaling in a Rabbit Model of Congenital Diaphragmatic Hernia
… Conclusion: TO reversed PH and stimulated early Wnt signaling in CDH fetal rabbits.
-
Characterization of Dishevelled Associated Activator of Morphogenesis 2 (Daam2) in Wnt Signaling During Early Embryonic Development
The Wnt signaling pathway is highly conserved in metazoan animals. Wnt signaling regulates an array of cellular processes that include motility, polarity, cell fate determination, primary axis formation and organogenesis and recently have been implicated in stem cell renewal. Deregulated Wnt …
-
The roles of FGF and Wnt signaling during maxillary barbel regeneration in the Zebrafish (Danio rerio).
… Fibroblast growth factor (FGF) and wingless (Wnt) signaling are required for the control of zebrafish caudal fin regeneration; due to the similarities between the fin and the maxillary barbel, these regulatory networks may play a role in barbel regeneration as well. In this study, I explored …
Page 1 of 7