Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 14 of 14 for “"Wnt Proteins"”.
-
Wnt Secretion Proteins Modulate RANKL-Induced Expression of Aire in Thymic Epithelial Cells
… In the thymus, TECs differentially express Wnt proteins, which activate canonical and non-canonical Wnt signaling pathways. Wnt signaling is thought to regulate cell survival, proliferation, and development although the direct molecular mechanisms in TECs have yet to be elucidated. The …
-
Cellular mechanisms involved in Wnt8 distribution and function in zebrafish neurectoderm patterning
Wnt proteins have key roles in patterning of multicellular animals, acting at a distance from their sites of production. However, it is not well understood how these molecules propagate. This question has become even more puzzling by the discovery that Wnts harbour post-translational …
-
Mechanisms of Genome Buffering and Cell Fate Coordination in Adult Tissue Homeostasis
… and intercellular communication mediated by the Wnt family of secreted signaling molecules, and epigenetic mechanisms that buffer the proteome against insertion/deletion (INDEL)-type genetic mutations. Wnt-mediated signaling is essential for embryogenesis and the maintenance of adult tissues. …
-
THE EFFECTS OF ESTROGENIC COMPOUNDS ON ADIPOGENESIS VIA PPARγ AND CANONICAL WNT SIGNALING
… potential interactions with PPARγs, canonical WNT proteins, and estrogen receptors (ER) signaling. The current investigation was conducted to test the effects of synthetic and natural estrogenic compounds (BDDA, daidzein, and genistein) for their effects on the induction of adipogenic …
-
The role of beta-catenin in the development of fetal ovary and female germ cells
… specifically in ovary. Wingless related protein (WNT) proteins are one class among them. WNT proteins are known to be essential for embryo development in many species. Multiple WNT ligands, including the ones that signal via the canonical β-catenin pathway, are expressed in fetal gonads, …
-
Wnt Signaling in Growth Cone Mediated Neurite Outgrowth from Spiral Ganglion Neurons in the Adult Mouse
… has been little investigation into the roles of Wnt proteins signaling through their Frizzled receptors in neuro-regeneration in the adult inner ear despite their involvement in axon guidance, dendrite morphogenesis, and synapse formation throughout the developing nervous system. In Chapter II, I …
-
Investigating The In Vivo Role Of Wnt Acylation
Wnts are a family of morphogens that play diverse roles in embryonic patterning, the maintenance of adult stem cells, and the evolution of cancers. Mammalian genomes contain 19 unique Wnt proteins which undergo post-translational acylation at a highly-conserved serine residue. All Wnts bind to the …
-
Discovery and Characterization of Novel Chemical Inhibitors of Wnt Ligand Production with Implications for Anti-Cancer Therapy
The widespread and indispensable nature of Wnt morphogens during early development has long been a focal point of embryogenesis research. More recently, pathway activation has been uncovered in adult stem cell niches and cancers arising from associated tissues. Consequently, interest has shifted …
-
Wnt9b Signals Through Two Distinct Pathways to Regulate Progenitor Maintenance, Differentiation and Morphogenesis During Kidney Development
… understood. Previous studies suggested that Wnt/_-catenin signaling was necessary and sufficient to induce tubule formation. Further, it was hypothesized that the pathway must be repressed in the progenitors to keep them in an undifferentiated state. However, using a combination of microarray …
-
Beta-Catenin and Development of the Urogenital System
… development of the urogenital system, canonical Wnt/beta-catenin signaling is known to play a significant role. To better understand the role Wnt signaling plays in reproductive tract development, we conditionally removed beta-catenin from the Wolffian duct using a HoxB7cre line of mice. We …
-
Wnt signaling in commissural axon guidance
… that guide these axons in the longitudinal axis. Wnt family members attract mouse commissural axon rostrally, while Sonic hedgehog (Shh) pushes chicken commissural axons towards the brain. We could show that the role of Wnt proteins is conserved in the chick. The molecular mechanism of Wnt action, …
-
Feedback Regulation of Wnt Signaling by Naked Cuticle (Nkd) During Drosophila Embryogenesis
Wnt/beta -catenin signals are essential for many developmental and physiological processes in animals. Deregulation of the Wnt signaling pathway in mammals can cause diseases such as birth defects, cancer, osteoporosis, and diabetes. In Drosophila, the naked cuticle (nkd) gene antagonizes the …
-
Functional Genomics Based Interrogation of Cell-Fate Determination Pathways
The Hedgehog (Hh) and Wnt signal transduction pathways are master regulators of embryogenesis and tissue renewal and represent anticancer therapeutic targets. Using genome-wide RNA interference screening in murine cultured cells, I established previously unknown associations between these signaling …
-
Quantitative Single-Cell Imaging Reveals Insulation of Morphogenic Signal Transduction
… simplicity is present in the integration between Wnt and Transforming Growth Factor Beta (TGFB), which are key developmental pathways. Surprisingly, this insulation extends to the integration of signals within the TGFB superfamily, which are expected to compete for shared components and so …