Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 439 for “"Wnt"”.
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Investigating WNT signalling in the lung
… oligohydramnios. As a branch of non-canonical WNT signalling, the planar cell polarity (PCP) pathway has emerged as a key ciliary signalling mechanism. Recent studies have highlighted the involvement of core PCP proteins in both ARPKD pathology and lung development and homeostasis. The aim of …
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Casein Kinase I Transduces WNT Signals
Wnt signaling controls a diverse array of processes including cell growth, oncogenesis, and development. Components of the Wnt cascade are altered in several human cancers including colon cancers and melanomas. We set out to identify novel components of this signal transduction pathway via …
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WNT SIGNALING AND HAIR FOLLICLE INITIATION
… cues for hair follicle initiation. Uniform Wnt signaling activity is present in dermal fibroblast precursors preceding hair follicle initiation, but the functional requirement of dermal Wnt signaling at early stages of skin differentiation and patterning remains largely uncharacterized. In …
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Regulation of Neuronal Polarity by Wnt Signaling
Wnts are highly conserved secreted glycoproteins that function in many developmental processes. Cell surface receptors, including the Frizzleds (Fz), ROR, and RYK families of proteins, bind Wnts to activate a number of downstream pathways. Wnts act redundantly to regulate the anteroposterior …
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Wnt-5a signaling in breast cancer metastasis
… breast cancer patients. It has been shown that Wnt-5a plays an important role in breast cancer, since loss of that protein is associated with a higher frequency of metastasis. The findings presented in this thesis show that Wnt-5a inhibits the metastatic behaviour of breast cancer cells by …
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Wnt/beta-Catenin-Zielgene in der Mausentwicklung
Der Wnt/beta-Catenin-Signalweg ist an der Steuerung vieler Prozesse während der Embryonalentwicklung beteiligt. Die zentrale Komponente des Signalwegs ist das Protein beta-Catenin, das an LEF/TCF-Transkriptionsfaktoren bindet und so Zielgene des Wnt/beta-Catenin-Signalwegs aktiviert. Ziel dieser …
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Wnt-/beta- Catenin Zielgene der frühen Mausentwicklung
… Arbeit wurden entwicklungsrelevante Zielgene der Wnt-/b- Catenin- Kaskade identifiziert. <br>Es wurde ein Zellkultursystem etabliert, mit dem es möglich war, unter einfachen experimentellen Bedingungen, die Wnt- Kaskade in Zellen induzieren zu können. Für das benutzte Zellkultursystem aus …
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Wnt Modulators, Secreted Frizzled Related Protein (sFRP) 2 and Wnt Inhibitory Factor (WIF)-1, Stimulate Melanogenesis in Normal Human Melanocytes
Wnt signaling plays a role in the differentiation as well as the development of melanocytes. Previous studies showed that hyperpigmentary skins of melasma express high levels of frizzled-related protein 2 (sFRP2) and Wnt inhibitory factor-1 (WIF-1) compared to perilesional normal skins. In this …
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Investigating The In Vivo Role Of Wnt Acylation
Wnts are a family of morphogens that play diverse roles in embryonic patterning, the maintenance of adult stem cells, and the evolution of cancers. Mammalian genomes contain 19 unique Wnt proteins which undergo post-translational acylation at a highly-conserved serine residue. All Wnts bind to the …
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Investigating the evolution and function of Wnt ligands
Wnt genes encode secreted glycoproteins which play an important role in development of all animals. Overall, thirteen subfamilies of Wnt ligands are present and all of them can already be found in the most basal metazoans. The importance of this large gene family and its evolutionary conservation …
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The Role of Wnt Signaling in Bone Mechanotransduction
… and low bone mass. In skeletal tissue, canonical Wnt signaling is a critical regulator of bone mass, and dysregulation of the Wnt pathway has been implicated in numerous skeletal displasias. Some components of the Wnt signaling pathway have a clear role in bone homeostasis, particularly in the …
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WNT signalling in the patterning of human gastruloids
… and leads to the formation of the body plan. WNT signalling, an evolutionary conserved pathway, is known to play a crucial role during gastrulation with its dysregulation leading to various developmental abnormalities and diseases. This thesis examines the role of WNT signalling in the …
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Selen, Selenoproteine und der Wnt-Signalweg : Regulation der gastrointestinalen Glutathionperoxidase durch β-Catenin und Beeinflussung des Wnt-Signalwegs durch den Selenstatus
… sich, dass die mRNA von Schlüsselgenen des Wnt-Signalwegs wie β-Catenin, Gsk3β, Dvl2, Tle2, Lef1 und c-Myc auf Schwankungen des Selengehalts reagiert. Vor allem die Induktion von c-Myc, einem Zielgen des Wnt-Signalwegs, deutet darauf hin, dass dieser im Selenmangel tatsächlich aktiver ist …
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Dact Family Molecules In Wnt Signaling In Mouse Development
The Wnt: Wingless-Integration) molecular signaling pathways are known to be integral in the embryonic patterning of multicellular animals, and are misregulated in multiple types of cancer. Wnt signaling includes multiple biochemical signaling pathways downstream of the Wnt family of secreted …
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Regulation of Lung Mesenchymal Cells By Epithelial Wnt Ligands
… and pericytes experience canonical Wnt signaling. We know that the alveolar type 1 (AT1) epithelial cell signals via Vascular Endothelial Growth Factor A towards the lung vasculature. Given the large surface area of the AT1 cell, we hypothesized they had additional signaling roles. …
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New roles for Hox and Wnt in Cell Migration
… I report new roles for established genes such as Wnt and Hox, and describe roles for several new genes in neuron migration. To study migrating neurons I use the model organism nematode worm Caenorhabditis elegans. With only 302 neurons, C. elegans is an excellent model to examine migration of …
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RacGap50C Is a Novel Negative Regulator of Wnt Signaling
<p>The Wingless (Wg)/Wnt signal transduction pathway directs a variety of cell fate decisions in developing animal embryos. Despite the identification of many Wg pathway components to date, it is still not clear how these proteins work together to generate cellular identities. We have carried out a …
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The role of Wnt signalling during embryonic salivary gland development
… spreads distally. We looked at the function of Wnt signaling during embryonic development of the submandibular and sublingual salivary glands and found that FGF signaling acts upstream of Wnt signaling and that Wnt and FGF signals coordinate branching morphogenesis and lumen formation. To locate …
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