Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"Withaferin A"”.
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Investigating the anti-inflammatory effects of plant derived compounds in tuberculosis using the THP-1 macrophage model
… to infection with live Mtb. We also showed that Withaferin A decreased IL-1β and IL-6 secretion in macrophages infected with Mtb prior to treatment with the compound. Finally, pre-treating macrophages with Withaferin A prior to infection with Mtb decreased the secretion of TNF and IL-6 compared …
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Role of cancer stem cells in breast and prostate cancer
… can induce GFP expression. Compounds related to Withaferin A have been proposed to specifically target CSCs. Prostate and breast cancer cell lines cultured in 2D and 3D were treated with a novel withanolide derivative (LG-02) and Withanilode E to determine if these compounds were more effective …
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Protein misfolding toxicity and inclusion formation in cellular models of neurodegeneration
… expressing polyQ with the steroidal lactone Withaferin A (WA) reduces toxicity while increasing aggregation. In essence, this study contributes to a deeper understanding of three misfolded proteins. Also, our results challenge the long-held postulation that aggregates cause neurodegeneration. …
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Characterizing and Influencing Intracellular Transport
… of intermediate filament organization with withaferin A significantly decreases vesicle motility in a dose-dependent fashion. Unlike microtubules and actin filaments, there are no molecular motors associated with intermediate filaments, so this result may be tied to cytoskeletal interactions …