Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 18 of 18 for “"Wistar rat"”.
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The effects of diet varying in fat content on the pathogenesis of diabetes mellitus in wistar rat offspring
… T2D is characterised by progressive deterioration of glycaemic control. These changes in glucose homeostasis are primarily due to ?-cell secretory dysfunction and/or peripheral insulin resistance. Studies show that maternal health directly influences foetal development and birth outcomes. …
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The role of the arterial glycocalyx in sphingosine-1- phosphate induced cardioprotection in the isolated heart of the Wistar rat
… of the glycocalyx during I/R in the isolated rat heart. Methods: Isolated male Wistar hearts were perfused on a Langendorff system with Krebs-Henseleit buffer via retrograde perfusion at constant temperature and pressure. The hearts were stabilized and pre-treated with S1P (10 nM for 7 …
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The effects of maternal diets, varying in fat content, on proximal hepatic and skeletal muscle insulin signalling in neonatal wistar rat offspring
… receptor alpha (IRα), insulin receptor substrate 2 (IRS2) and phosphoinositide 3-kinase-p110 alpha (PI3K-p110α), and to assess the therapeutic potential of Aspalathus linearis extract after high fat programming. Pregnant rats were randomised into groups maintained on diets with varying fat …
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Fracture healing : the effects of local insulin delivery via calcium sulfate and tricalcium phosphate
… fracture healing model of the diabetic BB Wistar rat, insulin will regulate early cellular proliferation and chondrogenesis and late mineralized tissue, cartilage content and mechanical strength. In this study, two novel delivery vehicles have been evaluated for sustained insulin release in …
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Endothelial Nitric Oxide Synthase and Growth Factor Regulation of Flow-Mediated Vascular Remodeling
… to characterize structural remodeling of male Wistar rat mesenteric arteries exposed to elevated blood flow in vivo for 1, 3, or 7 days. A series of arterial ligations induced blood flow increases in ileal and second-order branch arteries compared to same animal control vessels. Neither mean …
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Effect of Scutellaria Baicalensis on Reduction of Radiation/chemotherapy induced Inflammation
… extract (S) in vitro and in vivo using Wistar rat with methotrexate (MTX) induced enteritis or radiation induced proctitis. In vivo study, we used 6-8 week-old female Wistar rat. Rats for MTX induced enteritis were orally administrated once a day with three different concentrations (5, …
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Development and evaluation of the innovative 3D printed scaffolds for bone regeneration in vitro and in vivo /
… analysis results of bone tissue regeneration using various osteoconductive and osteoinductive (enhanced with dental pulp stem cells or their extracellular matrix) scaffolds in the Wistar rat critical-size calvarial defect model were analysed in the study. Moreover, the obtained results …
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Investigating systemic effects of chronic stress on hepatic and cardiac tissue in female Wistar rats
… these molecular mechanisms within female Wistar rat cardiac and hepatic tissues collected from a chronic restraint stress (CRS) parent study. Snap-frozen cardiac and hepatic tissues from female Wistar rats exposed to 28 days of CRS (n=8) or control conditions (n=8) were analysed. Redox …
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The effect of exercise on the utilization of dietary energy by the laboratory rat
… was to examine the effect of enforced moderate exercise, in combination with various dietary regimes on the efficiency of energy storage, mobilization and utlization in the male Wistar rat. The experimental approach adopted was to combine the carrying out of energy balance studies using the …
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Maternal separation in the rat : long-term effects of early life events on emotionality, drug response and neurobiology
… investigate early experiences. In the rat, maternal separation of pups in early ages have been linked to anxiety-related behavioral, endocrinological and neurochemical disruptions in the rat. The aim of the thesis was to investigate these proposed disruptions in pups exposed to repeated …
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Prenatal and postnatal nutritional influences on leptin sensitivity and susceptibility to diet-induced obesity in the rat
… development of diet-induced obesity (DIO) in the Wistar rat. A well established animal model of maternal undernutrition during pregnancy was used to induce prenatal undernutrition in experimental offspring. To investigate the interaction between prenatal nutrition and postnatal diet, and its …
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A NEUROPHARMACOLOGICAL ANALYSIS OF LEARNED HELPLESSNESS IN RAT (GENETICS).
… drugs reverse the deficits seen in a helpless rat, strongly suggests that the deficit is due to some neurochemical imbalance. This imbalance could be due to either the uncontrollable stressor or genetically induced. The three experiments suggest that there are fundamental differences in the way …
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Der Einfluss von tiefer Hypothermie und Wiedererwärmung auf den Sauerstoffverbrauch und das zirkulierende Blutvolumen der Ratte
… Sauerstoff assoziiert ist. Methodik: Männliche Wistar Ratten wurden auf 15°C Körpertemperatur abgekühlt. Diese Temperatur wurde entweder für 1 h oder für 5 h konstant beibehalten. Anschließend wurde auf 37°C wiedererwärmt. HZV, zirkulierendes Blutvolumen und andere hämodynamische Parameter …
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Trasduzione del segnale e poliamine nell'apoptosi di cellule cardiache
… human heart, are able to induce apoptosis of rat cardiomyocytes. Polyamines are biogenic amines involved in many cellular processes, including apoptosis. Actually it appears that these molecules can act as promoting, modulating or protective agents in apoptosis depending on apoptotic stimulus …
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CANNABINOID RECEPTORS (CB) IN COCHLEA: CHARACTERIZATION AND OTOPROTECTIVE FUNCTIONS
… immune cells and regulate the growth and proliferation of different immune cells and modulate the activities of cytokines network and anti-oxidant machinery in stress conditions. Inflammation plays a central role in hearing loss (HL) caused by different ototoxic insults including anti-neoplastic …
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Development of Novel PET Radiotracers for Neuroinflammation and COVID-19: Targeting FPR2, I2BS and ACE2
… brain functioning and can cause neurodegenerative diseases. Coronavirus disease 2019 (COVID-19) is an infectious disease spread rapidly across the world, threatening global health and causing huge economic losses. This work involves the development of novel small organic molecular probes …
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The amino acid sequence of the major alpha globin of the rat (Wistar, Rattus norvegicus)
1. Rat (Wistar, Rattus norvegicus) was found to possess six distinctive haemoglobin components. The major haemoglobin component E was prepared by chromatography on column of DEAE-Sephadex using a pH gradient. Globin chains were separated on a CM-cellulose column which was eluted with increasing …
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The role of norepinephrine in arousal and attention: a human and rat study
… the LCNE system to enhance the signal-to-noise ratio in stimulus-related neural networks. In addition terminal release of NE from LC neurons responds synergistically with glutamate release from glutamatergic neurons, thereby potentiating its signal. The Yerkes and Dodson (1908) theory of arousal …