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Showing 1 to 20 of 20 for “"Wilms tumor"”.
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The Expression and Function of Wilms' Tumor 1 in Malignant Glioma
The Wilms' tumor 1 gene is overexpressed in many types of cancer and is associated with poor prognosis and resistance to anti-cancer therapies. In vitro studies in non-glioma cells types have demonstrated that WTl plays a role in increased proliferation, resistance to apoptosis, and increased …
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Investigating the Role of DIS3L2 in Perlman Syndrome and Wilms Tumor
The general metadata -- e.g., title, author, abstract, subject headings, etc. -- is publicly available, but access to the submitted files is restricted to UT Southwestern campus access and/or authorized UT Southwestern users.
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Identification of Familial Wilms Tumor Predisposition Genes Using Whole Genome Sequencing
<p>Wilms tumor, a childhood tumor arising from undifferentiated renal mesenchyme, is diagnosed in North America at a frequency of 1 in 10,000 live births and accounts for 5% of all pediatric cancers. The etiology of Wilms tumor is heterogeneous with multiple genes known to have an effect on Wilms …
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Impact of Differentiation Status of Kidney Progenitors In Wilms Tumor Development
<p>Wilms tumor is one of the most common solid tumors in children. It is an embryonic cancer of the kidney and is thought to arise from undifferentiated renal mesenchyme. However, the differentiation status of cells in the mesenchyme that can give rise to Wilms tumors is unknown. Gene expression …
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Mutationsanalyse der verantwortlichen Gene NPHS2 und Wilms-Tumor-Suppressorgen beim Nephrotischen Syndrom
… welches für das Protein Podocin kodiert. Das Wilms-Tumor-Suppressorgen WT1 konnte als ein weiteres Gen identifiziert werden, das ebenfalls ein NS im Kindesalter verursacht. Es liegt auf Choromosom 11p13. Heterozygote Keimbahn-Mutationen in den Exonen 8 und 9 können ursächlich für die …
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The Wilms' tumor gene 1 (WT1) and leukemia -new insights and further complexity
The Wilms tumor gene 1 (WT1) encodes a zinc-finger containing transcription factor which is highly expressed in immature hematopoietic progenitor cells. A high expression of WT1 and the presence of somatic mutations in acute leukemia indicate a role for WT1 in the pathogenesis of leukemia. The …
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THE EFFECT OF SILENCING THE WILMS' TUMOR 1 GENE ON THE RADIATION SENSITIVITY OF GLIOBLASTOMA CELLS
… survival of only 9-12 months. This type of brain tumor is incurable, largely due its remarkable proliferative capacity and resistance to current treatments. High levels of the Wilms' Tumor 1 (WTI) gene have been identified in glioblastomas, suggesting an oncogenic function. Moreover, known WT1 …
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The role of Wilms’ Tumor gene product (WT1)in CD95-mediated apoptosis in T-cell leukaemias
… then bind on the CD95L promoter and activate it. Wilms’ tumor gene 1 (WT1) encodes a four-zinc-finger protein. Alternative splicing at the pre-mRNA level yields several transcript variants, of which the best characterized are the so called WT1-KTS and WT1+KTS isoforms. The WT1-KTS isoform, which …
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A four-and-a-half LIM protein FHL2 acts as a coactivator for the Wilms' tumor suppressor WT1 during gonadal differentiation
… of Müllerian inhibiting substance (MIS). The Wilms' tumor suppressor (WT1) and the orphan nuclear receptor steroidogenic factor 1 (SF-1) bind cooperatively to the promoter of MIS and activate its transcription. In the ovary, on the other hand, the orphan nuclear receptor DAX-1 binds to SF-1. …
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CYCLIN D1 AND WILMS TUMOR TRANSCRIPTION FACTOR-1 (WT1): POTENTIAL DIAGNOSTIC AND THERAPEUTIC MARKERS IN SMALL ROUND BLUE CELL TUMORS OF CHILDHOOD
Wilms tumor 1 (WT1) gene, firstly cloned in 1990 in the childhood kidney cancer Wilms tumor, is a gene located on chromosome 11p13, which encodes zinc-fingers protein characterized by multiple alternative isoforms, with important regulatory functions in cell growth and development. The protein …
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Prkca: Identification of A Novel Downstream Target of Wt1
<p>Wilms tumor is a childhood tumor of the kidney arising from the undifferentiated metanephric mesenchyme. Tumorigenesis is attributed to a number of genetic and epigenetic alterations. In 20% of Wilms tumors, Wilms tumor gene 1 (<em>WT1</em>) undergoes inactivating homozygous mutations causing …
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Wilms' tumour outcomes at Red Cross Children's Hospital 1979-2003
BACKGROUND: In Africa Wilms' tumour frequently presents with advanced disease. This study reports our results over 25 years using the National Wilms' Tumor Study Group approach of primary surgery, in the form of nephrectomy, followed by chemotherapy. A small number of these tumours are bilateral …
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Dysregulation of Meox2 Following Wt1 Mutation In Kidney Development and Wilms Tumorigenesis
<p>Wilms tumor (WT) is a childhood tumor of the kidney and a productive model for understanding the role of genetic alteration and interactions in tumorigenesis. The Wilms tumor gene 1 (<em>WT1</em>) is a transcriptional factor and one of the few genes known to have genetic alterations in WT and …
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Analysis and characterisation of the mouse Hic2 gene
… 22q11.2, and is a homolog of the HIC1 candidate tumor suppressor gene located at 17p 13.3. (Deltour et al. 2001). Upstream from the TATA box MatInspector predicted different transcription binding sites. Between them Wilms Tumor Suppressor and p53 are most interesting transcription sites for the …
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Distance to treatment center and other non-medical factors that can influence pediatric cancer survival
… lymphoblastic leukemia, central nervous system tumors, neuroblastoma, rhabdomyosarcoma, or Wilms tumor between the years 2000 and 2018 who were NC residents and treated at UNC Hospital. RESULTS: Distance to the UNC Hospital from a patient’s residence did not have a statistically significant …
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SOSTDC1: A BMP/Wnt Dual Antagonist in Breast and Renal Cancers
… occurs in 85-90% of breast and kidney tumors. It was hypothesized that extracellular BMP regulation by SOSTDC1 is protective against cancer; therefore, loss of SOSTDC1 may lead to tumorigenesis initiation or progression. This was investigated through studies of the SOSTDC1 gene locus on …
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Cardiac repair post-myocardial infarction: Roles of the primary cilium and the long non-coding RNA Malat1
… sufficient repair. The transcription factor Wilms’ tumor 1 (Wt1) and the primary cilium regulate EMT. Furthermore, the long non-coding RNA (lncRNA) Malat1 is not only known to regulate EMT, but also mitigates cell death from injury. Little is known about the roles of Wt1, primary cilia, and …
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Expressionskartierung des menschlichen Chromosoms 11p13
… mehrere krankheitsrelevante Gene wie das Wilms' Tumor Gen WT1 oder das für die Aniridie verantwortliche Gen PAX6. Beide Gene können bei Patienten mit dem WAGR-Syndrom deletiert sein, was das Auftreten von Wilms' Tumoren oder Aniridie bei diesen Patienten erklärt. Die genetische Ursache für …
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Advancement of A 3D Computational Phantom and Its Age Scaling Methodologies For Retrospective Dose Reconstruction Studies
… quantifying the difference in dose from standard Wilms’ tumor RT plan simulated on exact age-scaled and nearest age-matched phantom while using the same field size and anatomical landmark dependent field size in two different scenarios.</p> <p>This study showed that phantoms were implemented in …
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Engineering and characterization of human single-chain T cell receptors
… MHC. In Chapter 3, a human scTCR specific for Wilms’ Tumor Antigen-1 (WT-1) was engineered for improved stability and affinity by yeast display through a multi-step affinity maturation process. This scTCR was also expressed in E. coli as a soluble scTCR and used to detect WT-1/HLA-A2 on the …