Global ETD Search
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Showing 1 to 7 of 7 for “"Wilms Tumour"”.
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WILMS’ TUMOUR GENE 1 PROTEIN (WT1) – AN EFFECTOR IN LEUKEMOGENESIS?
Wilms’ tumour gene 1 (WT1) encodes a zinc-finger transcription factor functioning as a key regulator in organ development. WT1 was first identified as a tumour suppressor gene due to its inactivation in Wilms’ tumour cases, a childhood kidney cancer. In adult tissues WT1 expression is restricted to …
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Identification, Validation and Implementation of Blastemal Biomarkers in Wilms Tumour
… biomarkers for the blastemal element in Wilms tumour (WT) – the most common paediatric kidney cancer. Blastema is, together with epithelium and stroma, one of the three common histological elements of WT. WTs dominated by blastema after preoperative chemotherapy are classified as high …
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Wilms' tumour outcomes at Red Cross Children's Hospital 1979-2003
BACKGROUND: In Africa Wilms' tumour frequently presents with advanced disease. This study reports our results over 25 years using the National Wilms' Tumor Study Group approach of primary surgery, in the form of nephrectomy, followed by chemotherapy. A small number of these tumours are bilateral …
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Involvement of the WT1 and p16 genes in Wilms' tumour and human malignant mesothelioma
… regulators, they are termed oncogenes or tumour suppressor genes, respectively. Identified human tumour suppressor genes, though still relatively few in number, are found to be active in many different cellular processes. I have studied two such genes, the WT1 and p16 genes, which in their …
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Imaging of tumours of the urinary tract in children, with particular reference to Wilms' tumour
… the urinary tract. The commonest neoplasm is a Wilms' tumour of the kidney. Against a pathological and clinical background, the investigation of Wilms' tumour by diagnostic imaging is presented. The imaging modalities currently utilised are the intravenous urogram (IVU), ultrasound (US), …
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Mechanisms and Consequences of Chromosomal Instability in Malignant tumours
… established colorectal cancer cell lines and in Wilms tumour. In colorectal cancer cell lines, anaphase bridging was observed to generate both numerical and structural chromosomal aberrations and was also associated with the presence of multipolar mitoses. In contrast to cells having undergone …
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Lineage tracing of normal human development and childhood cancers
… In the context of phylogenetic analyses of tumours, mutations shared between childhood cancers and different normal tissues can shed light on the embryonic lineage of tumours and may reveal the precise juncture at which tumours began to form. Accordingly, I studied the origin of Wilms …