Global ETD Search
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Showing 1 to 5 of 5 for “"Wilms´ tumor gene 1"”.
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The Wilms' tumor gene 1 (WT1) and leukemia -new insights and further complexity
The Wilms tumor gene 1 (WT1) encodes a zinc-finger containing transcription factor which is highly expressed in immature hematopoietic progenitor cells. A high expression of WT1 and the presence of somatic mutations in acute leukemia indicate a role for WT1 in the pathogenesis of leukemia. The …
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Impact of Differentiation Status of Kidney Progenitors In Wilms Tumor Development
<p>Wilms tumor is one of the most common solid tumors in children. It is an embryonic cancer of the kidney and is thought to arise from undifferentiated renal mesenchyme. However, the differentiation status of cells in the mesenchyme that can give rise to Wilms tumors is unknown. Gene expression …
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The role of Wilms’ Tumor gene product (WT1)in CD95-mediated apoptosis in T-cell leukaemias
… then bind on the CD95L promoter and activate it. Wilms’ tumor gene 1 (WT1) encodes a four-zinc-finger protein. Alternative splicing at the pre-mRNA level yields several transcript variants, of which the best characterized are the so called WT1-KTS and WT1+KTS isoforms. The WT1-KTS isoform, which …
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Prkca: Identification of A Novel Downstream Target of Wt1
<p>Wilms tumor is a childhood tumor of the kidney arising from the undifferentiated metanephric mesenchyme. Tumorigenesis is attributed to a number of genetic and epigenetic alterations. In 20% of Wilms tumors, Wilms tumor gene 1 (<em>WT1</em>) undergoes inactivating homozygous mutations causing …
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Dysregulation of Meox2 Following Wt1 Mutation In Kidney Development and Wilms Tumorigenesis
<p>Wilms tumor (WT) is a childhood tumor of the kidney and a productive model for understanding the role of genetic alteration and interactions in tumorigenesis. The Wilms tumor gene 1 (<em>WT1</em>) is a transcriptional factor and one of the few genes known to have genetic alterations in WT and …