Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 433 for “"Wildtype"”.
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Cholinergic Regulation of the Mammalian Circadian System: Phase Shifting in Vivo and in Vitro in Wildtype and M(1) Knockout Mice Induced by Cholinergic Agonists
These experiments demonstrate that ACh regulates the circadian clock via at least two different pathways. One induces phase advances throughout the night and is mediated via the M1AChR. The other causes a biphasic, light-like response and is not mediated via the M1AChR.
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Studi funzionali e strutturali sul wildtype e sul mutante γM23-K della ATP sintasi di Rhodobacter capsulatus: ruolo dell'ADP e della forza protonmotiva nell'attivazione dell’enzima e nell'accoppiamento dell'idrolisi di ATP alla traslocazione protonica
… mediante inibizione parziale dell’idrolisi del wildtype ha inoltre mostrato come il grado di accoppiamento del mutante in condizioni standard non differisca sostanzialmente da quello del wild-type. D’altro canto, è stato recentemente osservato come un disaccoppiamento intrinseco possa venire …
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Effects of The Acta2 R258C Mutation On Vascular Smooth Muscle Cell Phenotype and Properties
… an <em>Acta2 </em>R258C mutant transgene with a wildtype <em>Acta2 </em>promoter were generated and bred with <em>Acta2<sup>-/-</sup> </em>mice to decrease the wildtype: mutant <em>Acta2 </em>ratio. <em>Acta2<sup>+/+ R258C TG</sup></em>mice have decreased aortic contractility without aortic …
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Cold-Induced Metabolic Changes in Lean, NAG-1 Transgenic Mice
… metabolic rates, and longer lifespans than their wildtype littermates. Wildtype and NAG-1 mice were subjected to a prolonged cold exposure at 10ºC for seven days. NAG-1 mice had lower body weights throughout the study compared to wildtype mice. NAG-1 mice had higher metabolic rates before and …
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The Problem of Life: Governing Bodies Before and Beyond Biopolitics
… make this claim demonstrable, it introduces the wildtype framework as a comparative instrument. Borrowed from genetics, where the wildtype designates a strategically constructed reference organism against which mutations are measured, the framework asks three diagnostic questions of any governing …
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Functional and ecological investigations in Cucurbita: factors mediating fruit infections and insect interactions
… gene cbhA in disease development by comparing a wildtype IL 234 4R isolate to a ΔcbhA mutant in greenhouse fruit inoculation trials. Eight experiments were conducted, including four with the wildtype isolate alone, and four comparing wildtype and mutant strains. Regression analysis of …
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Role of Properdin in Tumour Growth and Cell Recruitment
… engineered to be properdin deficient and their wildtype controls.<br/>The in vitro part of the project used macrophages differentiated from bone<br/>marrows of these mice and stimulated with conditioned medium of a syngeneic<br/>mouse melanoma cell line, B16F10. In comparison with macrophages …
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Alveolar stem cell dynamics and regulatory mechanisms in homeostasis and early oncogenesis
… tumours. Here, I trace thousands of individual wildtype and oncogene-expressing mutant AT2-derived clones across multiple timepoints *in vivo* to shed insight into the early events driving neoplastic transformation. By integrating immunofluorescent analysis with 3D reconstruction and …
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Purification, Characterization, and Active Site Studies of 2-(2'-Hydroxyphenyl) Benzenesulfinate Desulfinase (DSZB) from Nocardia Asteroides Sp. Strain A3H1
… in the last, and rate limiting step. The wildtype A3H1-DszB and the recombinant A3H1- R84Q-Y24Fand A3H1-R84Q-C27S DszBs from Nocarida asteroides sp. strain A3H1 were purified and characterized. The A3H1-R84Q-C27S- DszB was inactive. The temperature and pH optima for wildtype and …
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Synaptic Plasticity in the Cerebral Cortex of Fragile X Knockout Mice
… cortex was examined in young Fmr1 knockout and wildtype mice. The rate of developmental synaptogenesis between the two genotypes was similar, but Fmr1 knockout mice exhibited levels of synaptic protein synthesis lower than those of wildtype mice. The role of FMRP in experience-dependent brain …
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Exploring the Physiological Role of Vibrio fischeri PepN
… populating the host’s light organ compared to wildtype within the first 12 hours of colonization; however the mutant competed normally at 24 hours. To address the role of PepN in colonization initiation and establish additional phenotypes for the pepN mutant strain, stress response and other …
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Application of molecular biology techniques in the assessment of microbial community responses to environmental perturbations
… genetically-engineered Erwinia carotovora and wildtype declined significantly (p ≤ 0.05) over a 60 day period. Interestingly, in the clay soil, both the GEM and wildtype remained at decreased but detectable levels (using the MPN technique) after 60 days. In the loam soil, the GEM declined below …
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Identifizierung und Untersuchung eines Magnesium-Transportproteins in der Spalthefe Schizosaccharomyces pombe
… normal grow conditions the disruptant and the wildtype strains showed similar growth rates. If the cells grew in medium without magnesium, the disrupted strains stopped growing earlier compared to the wildtype. The addition of magnesium restored growth. A magnesium specific staining showed that …
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Metabolomic analysis of the interleukin-10-deficient mouse model of Crohn's disease
… the urinary metabolite profiles of IL10-/- and wildtype C57BL/6 mice. Xanthurenic acid and fucose were identified as the main urinary metabolites associated with the early stage of intestinal inflammation. Their levels were increased in IL10-/- mice relative to wildtype. Xanthurenic acid levels …
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Phänotypische und genotypische Charakterisierung der ENU-induzierten Mausmutante HST001 zur Verwendung für die nephrologische Forschung
… were divided in the two groups of mutant and wildtype littermates according to the concentration of plasma urea. The mutation showed complete phenotypic penetrance in all generations examined. In addition the genomic localization of the causative mutation was determined by linkage analysis. At …
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The role of Cysteinyl leukotriene receptor-1 during experimental helminth infections in murine model
… lymphoid organs in cysLTR1-/- as compared to wildtype mice. Primary infection with N. brasiliensis indicated increased worm burden in cysLTR1-/- mice at day 7 post infection and a delay in the resolution of infection by day 9 post infection when compared to wild type mice. Furthermore, we …
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Function Study of Atrial Fibrillation-Linked Connexin Mutants and Heterotypic Docking Compatibility of Cardiac Connexins
… also the case for cells co-expressing L221I and wildtype Cx40, suggesting increased hemichannel opening probability. A novel AF-linked Cx45 mutant (M235L) was found to impair GJ function. These alterations in hemichannel or GJ function might play a role in promoting AF. The atria express Cx40 and …
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Investigating Cadm2 genetic variation in attention and motivation
… (rCPT) using touchscreen chambers. Our cohort of wildtype, heterozygous and knock-out Cadm2 mice were run on rCPT and a Progressive Ratio task to investigate how the impulsive and motivation related behaviours of these animals may differ. We discovered that Cadm2 genetic variation resulted in …
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