Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 17 of 17 for “"Whole-genome Analysis"”.
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Whole Genome Analysis of Escherichia coli and Pseudomonas aeruginosa Mixed Culture Biofilms Grown for 117 Days in Spaceflight
… 19 spaceflight isolates were chosen to undergo whole genome sequencing to be compared to the ancestral strain genomes. Illumina and Nanopore reads were used obtain draft genomes via a hybrid assembly. Whole genome alignment was used to identify differences, including SNPs, amongst the …
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Whole genome analysis of the koa wilt pathogen (Fusarium oxysporum f. sp. koae) and development of molecular tools for early detection and monitoring
… assays. Chapter two of this thesis examined whole genomic comparisons of a pathogenic F. oxysporum f. sp. koae (Fo koae 44) and a F. oxysporum (Fo 170) isolate found to be non-pathogenic to Acacia koa, for the identification of genomic features that could be used to distinguish pathogenicity. …
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Characterization of inducible antibiotic production by streptomycetes isolated from hyper-arid environments
… research project employed bioactivity assays, whole-genome analysis and metabolomics to determine the antibiotic potential from bioassays, identification of potential biosynthetic gene clusters and the elucidation of the compounds(s) responsible for the activity. Fourteen strains, closely …
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Molecular Characterisation Of Clostridium Perfringens Isolates From Patients At Groote Schuur Hospital
… typing, antimicrobial susceptibility testing and whole genome sequencing. Strains were isolated from patients with invasive clostridial disease. In agreement with other studies, toxin typing confirmed that all isolates encode the Phospholipase C (plc) gene which encodes for the tissue-destructive …
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ONCOGENE-INDUCED ALTERED DNA REPLICATION DYNAMICS
… hyper-proliferation. By performing a whole genome analysis of DNA replication dynamics occurring upon oncogene activation, I discovered that oncogene activation alters DNA replication by increasing replication fork speed and fork stalling, while decreasing the frequency of replication …
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Characterization of two component systems of Acinetobacter baumannii.
… of putative two component systems encoded in the genome of A. baumannii that await detailed characterization. Differential expressions of six different TCSs was observed in two clinical isolates of A. baumannii AB030 and AB031, and whole-genome sequencing of both clinical isolates was performed. …
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COVID-19 Variant Analyzer through Genomic Sequences and Jaccard Similarities
… a database-driven approach and genomic sequence analysis. The framework utilizes MySQL database architecture where each variant is stored in distinct tables, enabling rapid comparison and classification of new variants through Jaccard similarity calculations. The innovative aspect of this …
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DD34E DNA Transposable Elements of Mosquitoes: Whole-Genome Survey, Evolution, and Transposition
… and spreading within, and in some cases, between genomes. I describe a whole-genome analysis of DD34E TEs, which belong to the IS630-Tc1-mariner superfamily of DNA transposable elements, in the African malaria mosquito, Anopheles gambiae. Twenty-six new transposons as well as a new family, gambol, …
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Genetic studies of candidate genes in the glycoalkaloid biosynthetic pathway of potato
… crops. Both a candidate gene approach and a whole genome SNP genotyping analysis were used to assess allelic variation and to identify loci associated with biosynthesis and accumulation of steroidal glycoalkaloids (SGAs). SGAs are secondary metabolites produced in Solanum species as defense …
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Maintaining the balance: persistent baculovirus infection in insect cells
… a persistent rather than latent infection. Analysis indicated that only a small proportion (<7%) of cells were producing BV whilst superinfection studies demonstrated that the majority of cells were resistant to a secondary infection. Microscopy studies indicated that superinfection may be …
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Zebrafish as a Model for Studying Estrogen Signaling and Estrogenic Endocrine Disruption
… In the studies of this dissertation, first a whole-genome analysis of estrogen regulated genes in zebrafish embryos/larvae at different developmental stages was performed. The identified estrogen-responsive genes were distinct between the four time points, however GO biological process …
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Influenza Dynamics from Pre-pandemic to Post-pandemic Periods: Epidemiology and Genetic Characteristics
… important insights for public health responses. Analysis of local diagnostic PCR data from two major metropolitan health districts found a near-absence of influenza viruses between April 2020 and 2021, followed by a resurgence of cases in 2022 (Chapter 2). Notably, peak influenza activity in 2022 …
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Sex Chromosome Evolution in Blow Flies
… a total of nine male and female individual draft genomes for each of the four species (including three individual draft genomes of Chrysomya rufifacies – male, and the two females) were sequenced and assembled providing genomic data to explore sex chromosome evolution in blow flies. Whole genome …
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The Role of Multidrug Efflux Pumps in the Stress Response of Pseudomonas aeruginosa to Organic Contamination
… of chemical stressors; however, research on whole genome responses to this contaminant stress is limited. This research examined the stress response of a common soil bacterium, <i>Pseudomonas aeruginosa</i>, to a common environmental pollutant, pentachlorophenol (PCP). In the first part of …
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Imaging genetics evidence for the neurodevelopmental model of schizophrenia
… between individual brain regions. We accessed genome-wide association studies (GWASs) for surface area (SA), cortical thickness (CT) and NDI measured at 180 cortical areas (N = 36,843,UK Biobank). Using Hi-C coupled MAGMA (H-MAGMA), we identified 318 genes that were significantly associated …
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Bioinformatic methods in mammalian genomics: applications towards conservation and health
Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2025-10-20 without embargo terms
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Isolation, Characterisation and Preservation of Bacteriophages for Use in Treatment of Aeromonas hydrophila Infection In Finfish
… bacteria. Four selected phages were subjected to whole genome sequencing using Illumina technologies with a view to determining their phylogeny, adaptive evolution, biodiversity, potential virulence and presence of any toxin genes. The isolated and selected phages were then subjected to a study to …