Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 14 of 14 for “"White matter lesions"”.
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Patterns of cognitive impairment in multiple sclerosis and their relationship to neuropathology on magnetic resonance imaging
… cognitive changes dependent upon the site of white matter lesions. The present study explored this question using cluster analysis on the neuropsychological data from a group of mildly disabled MS patients (n = 177) and a well-matched control group (n=89). In a group of MS patients who were …
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Utilisation of novel magnetic resonance imaging features in the diagnosis and understanding of multiple sclerosis
… to demonstrate the requisite dissemination of lesions in (anatomical) space and time. Lesions comprising inflammatory demyelination in the central nervous system are a core pathological feature of MS. Ultra-high field (e.g. 7 Tesla or 7T) T2*-weighted MRI can demonstrate in vivo a central vein …
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Distinct contribution of white matter damage to the clinical syndrome of Alzheimer's disease
… several other changes occur, including severe white matter damage that is yet to be fully understood. Such white matter damage includes white matter lesions (WML), which are more common in individuals with Alzheimer's disease than in non-demented individuals. WML are of presumed vascular origin …
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Studies on the Mislocalized Exonuclease TREX1 that Causes a Systemic Vasculopathy
… due to small vessel occlusions in the retina and white matter of the brain. Neuroimaging reveals frontoparietal mass-occupying lesions often with substantial edema and scattered white matter hyperintensities. The mean age at diagnosis is 42.9 ± 5.3 years and the disease leads to premature death …
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The effect of repetitive head impact exposure on white matter lesion volume
… on whether RHI from CCS result in changes to white matter and long-term neurobehavioral outcomes, therefore this research project seeks to provide supporting evidence by comparing the total volume of fluid-attenuated inversion recovery (FLAIR) white matter lesions in individuals with a history …
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Associations of serum zinc and copper concentrations within cardiovascular and neurological traits
… brain (micro-)structure, such as total grey and white matter volume, white matter lesions and global fractional anisotropy. 595 individuals diagnosed with MDD had significantly lower serum zinc and higher serum copper concentrations than 445 community-dwelling controls. In controls, higher serum …
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Microglial succinate receptor 1 (SUCNR1) sustains chronic CNS inflammation
… by myeloid cells in chronic inflammatory lesions. Post mortem single-molecule fluorescence in situ hybridization (smFISH) and histopathology analysis of people with progressive MS confirmed a predominant expression of SUCNR1 in chronic active and active white matter lesions. When EAE was …
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Blood-Brain Barrier Permeability and Inflammation in Cerebral Small Vessel Disease
… of vascular dementia. It is characterised by white matter lesions and more diffuse damage outside of the lesions. Despite its importance, the mechanisms causing white matter damage are incompletely understood. Both increased blood-brain barrier (BBB) permeability and inflammation have been …
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Perinatal hypoxic-ischemic brain injury – characterization, mechanisms and treatment
… hypothermia significantly reduced cortical and white matter lesions and axonal and myelin injury, evidence of axonopathy persisted in the white matter after treatment with hypothermia after ischemia in near-term fetal sheep. Hypothermia was associated with only partial reduction in microgliosis …
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Vascular risk and depression in outpatients at Groote Schuur Hospital memory clinic
… elderly has been linked with stroke, and with white matter lesions, particularly in frontal-subcortical regions responsible for mood regulation. Such evidence of vascular disease has in turn been associated with vascular risk factors such as diabetes, hypertension, smoking, high cholesterol and …
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Neurovascular mechanisms of cognitive aging: A multimodal neuroimaging investigation
Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2024-03-01 without embargo terms
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NEUROFIBROMATOSIS TYPE 2 PROTEIN (NF2) AS A REGULATOR OF TUMOR SUPPRESSORS AND VIRAL ONCOPROTEINS IN HUMAN GLIOBLASTOMA
… their lytic destruction and the development of white matter lesions in PML patients. Its main regulatory protein, large tumor antigen (T-antigen), targets p53 to retain cells in a virus-producing state, thereby conveying an accidental oncogenicity. JCV T-antigen transgenic mice develop a …
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Klinische Korrelate von Läsionen der weißen Substanz bei Patienten mit Alkoholkrankheit
Einleitung: Zahlreiche Untersuchungen haben belegt, dass die bekannten zerebrovaskulären Risikofaktoren mit einem vermehrten Auftreten von Läsionen der weißen Substanz (WSL) verknüpft sind. Die Datenbasis bezüglich der Rolle des Alkohols bei der Entstehung von WSL ist bis heute schlecht. Ziel …
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Pathophysiological Mechanisms and Diagnostic Markers in Alzheimer’s Disease
… of vascular disease. In order to explore how white matter changes (WMLs) affects the course of disease, we analyzed CSF levels of phosphorylated tau (P-tau) and assessed WMLs on brain scans in healthy controls and patients with mild cognitive impairment. We found that a pathological level of …