Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 14 of 14 for “"White Matter Hyperintensities"”.
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Data-Driven Insights into Spatial Patterns and Disease Etiologies of White Matter Hyperintensities
… (opNMF) to identify spatial patterns of white matter hyperintensities (WMH) within UK Biobank's imaging data. Our selection criteria excluded subjects with a history of neurological, mental, and specific cerebrovascular conditions, allowing us to focus on WMH patterns in a healthy aging …
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The Moderating Effect of Physical Activity on the Association between White Matter Hyperintensities and Gait Characteristics
… of this thesis were; 1) to assess the effect of white matter hyperintensities (WMH) burden on motor outcomes among older individuals in presence and absence of overt neurological conditions and 2) to evaluate whether physical activity (PA) moderated the association between WMH and gait velocity …
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White matter hyperintensities and lower extremity physical function before and after an aerobic exercise intervention in healthy older adults
… Age-related declines take many forms including white matter deterioration, cognitive impairments, and mobility limitations, all of which can have practical implications, such as falling and making risky pedestrian decisions. Modifiable lifestyle interventions, like physical activity, provide …
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THE CONTRIBUTION OF PHYSICAL ACTIVITY TO NEUROIMAGING INDICES AND COGNITIVE FUNCTION IN HEART FAILURE
… whether specific neuroimaging indices (i.e. white matter hyperintensities (WMH) and medial temporal lobe atrophy (MTA)) mediate the relationship between physical activity and cognitive function in persons with HF. Eight-five HF patients completed a brief neuropsychological battery, brain …
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Depressive Symptoms and Subclinical Vascular Disease: A Cross-Cultural Comparison
… subclinical cerebrovascular impact is cerebral white matter hyperintensity volume (WMHv). Differences in WMHv have been reported across ethnic groups, and WMHv is more closely associated with the cardiovascular risk factors that are higher in African Americans. White matter hyperintensities …
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Examining the Association between Brain MRI Measures at 7 Tesla and cognition following COVID-19 Infection
… differences in other cognitive domains. Although white matter hyperintensities were visible on fluid attenuated inversion recovery (FLAIR) images in 22 of 43 participants consistent with small vessel ischemic disease and migraine, this incidence is consistent with that expected in a normative …
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Exploring neurodegeneration in Ataxia-Telangiectasia
… study the natural history of A-T and evaluated white matter hyperintensities, cerebral microbleeds and cognitive phenotype in adult A-T patients. I have also evaluated potential MRI and serum biomarkers. Finally, I have explored mitochondrial dysfunction and response to mitochondrial DNA …
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The effect of repetitive head impact exposure on white matter lesion volume
… on whether RHI from CCS result in changes to white matter and long-term neurobehavioral outcomes, therefore this research project seeks to provide supporting evidence by comparing the total volume of fluid-attenuated inversion recovery (FLAIR) white matter lesions in individuals with a history …
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Measuring Brain Iron In Healthy Controls And Accessing Venous Abnormalities In Parkinson's Disease Using Mri
… and ∆R2^* as a function of age in seven gray matter nuclei. We also studied how the high iron region in the structures change over time, which is a more sensitive way to study the brain iron deposition. Quantitative susceptibility mapping (QSM) is another approch we used to study normal brain …
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Elucidating the Impact of Previous Head Injury on Cognition, Brain Structure, and Pathophysiology in Cognitively Normal Individuals Across the Adult Lifespan
… on 1) cognitive performance and change and 2) white matter hyperintensities (WMH) and hyperphosphorylated tau (pTau) burden, a protein associated with neurodegenerative disorders. Participants from the Dallas Lifespan Brain Study (DLBS) (aged 20-90 at baseline) completed two assessments related …
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The role of cerebral small vessel disease in dementia
… quantified on 3T MRI through the assessment of white matter hyperintensities (WMH), enlarged perivascular spaces (EPVS), cerebral microbleeds (CMB), and lacunes. Regional data on SVD location was used to derive composite scores for global SVD burden, and the SVD subtypes of hypertensive …
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Evaluating Magnetic Resonance Imaging and Serum Markers As Surrogate Endpoints for Clinical Trials in Cerebral Small Vessel Disease
… vascular cognitive impairment and dementia. White matter hyperintensities, lacunar infarcts, cerebral microbleeds and brain atrophy are characteristic features on conventional magnetic resonance imaging (MRI). More sensitive methods such as diffusion tensor imaging (DTI) show white matter …
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Disease mechanisms and markers of progression in cerebral small vessel disease
… to clarify elements of the natural history of white matter hyperintensity lesions (WMHs) in SVD. These are a key radiological feature of SVD that are strongly correlated with clinical sequelae, and I further tested whether brain lesion volume can regress over time. In part II I investigated the …
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Studies on the Mislocalized Exonuclease TREX1 that Causes a Systemic Vasculopathy
… due to small vessel occlusions in the retina and white matter of the brain. Neuroimaging reveals frontoparietal mass-occupying lesions often with substantial edema and scattered white matter hyperintensities. The mean age at diagnosis is 42.9 ± 5.3 years and the disease leads to premature death …