Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 16 of 16 for “"White Matter Damage"”.
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Ionic dysregulation in white matter damage
White matter damage can occur in a variety of neurological diseases where it contributes significantly to impairment of brain function. Dysregulation of ion gradients across membranes is a common phenomenon across many diseases and can be damaging due to increased metabolic demand, oedema and …
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Periventricular white matter damage in the post-natal brain in hypoxic conditions
… a major factor contributing to periventricular white matter (PWM) damage in neonates. Microglial cells and astrocytes play a crucial role in inflammatory response. This study investigated their role in PWM damage (PWMD) in hypoxic conditions. The potential mechanisms by which amoeboid microglial …
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Distinct contribution of white matter damage to the clinical syndrome of Alzheimer's disease
… several other changes occur, including severe white matter damage that is yet to be fully understood. Such white matter damage includes white matter lesions (WML), which are more common in individuals with Alzheimer's disease than in non-demented individuals. WML are of presumed vascular origin …
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The relationship between neurocognitive disorders, prospective memory impairment and white matter damage in clade C HIV-positive subjects
… function and Diffusion tensor imaging (DTI)/ White matter integrity of human immunodeficiency virus (HIV) positive individuals in the Western Cape. We hypothesize that: 1. Individuals infected with HIV will exhibit significantly poorer microstructural integrity of the white matter than HIV …
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Investigating the role of TREM2 and neuroinflammation in an experimental model of chronic cerebral hypoperfusion
… disease is associated with the development of white matter damage, cognitive impairment and dementia. Although incompletely understood, recent studies suggest neuroinflammation is a key mechanism driving vascular pathology, white matter damage and cognitive decline. Neuroinflammation is …
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Blood-Brain Barrier Permeability and Inflammation in Cerebral Small Vessel Disease
… of vascular dementia. It is characterised by white matter lesions and more diffuse damage outside of the lesions. Despite its importance, the mechanisms causing white matter damage are incompletely understood. Both increased blood-brain barrier (BBB) permeability and inflammation have been …
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Quantitative Analysis of Ultrasound Images of the Preterm Brain
… are proposed to better understand and diagnose white matter damage in the preterm Brain. Since Ultrasound imaging is the most suited modality for the inspection of brain pathologies in very low birth weight infants we propose multiple techniques to assist in what is called Computer-Aided …
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On the neurobiology of apathy and depression in cerebral small vessel disease
… We show that apathy is related to focal grey matter damage and distributed white matter microstructural change. These microstructural changes underlie large-scale white matter network disruption, which is related to apathy, but not depression. We then show that depression, as a construct, can …
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A diffusion tensor imaging and neurocognitive study of ART-naïve and ART-treated children in Cape Town
… to HIV infected children this DTI study found damaged neuronal microstructure in the HIV infected children. Significant associations were found between failing first line ART regimen, socio-demographic factors, nutritional-hematological status, HIV-relevant clinical variables, cognitive …
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The Role of Specific Integrase Strand Transfer Inhibitors (INSTIs) in the Alteration of Oligodendrocyte Maturation and Myelination in Hand
… present as non-specific gliosis, synaptodendritc damage and loss of white matter and myelin. Furthermore, the severity of white matter damage correlates with the length of ART duration. However, almost no studies have been performed to determine how the myelin sheath or the oligodendrocytes that …
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Effects of Sex and Aging in the Response to Global Cerebral Hypoperfusion
… such as inflammation, neuronal loss, white matter abnormalities, and blood- brain barrier disruption, has been successfully modeled in mice using bilateral common carotid artery stenosis (BCAS). Most BCAS studies have used young male mice, overlooking potential age and sex differences …
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Structural organization in 9-year-old HIV-infected children and HIV-exposed children
… continue to report HIVrelated neurodevelopmental damage and delays. Neuroimaging and neuropsychological studies have identified brain regions and cognitive domains vulnerable to the effects of HIV infection and exposure in children. As most studies focus on a single time point, it is unclear if …
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Investigation of inflammatory and oxidative stress mechanisms in the disruption of white matter structure and function following chronic cerebral hypoperfusion
… with an increased risk of developing VCI. White matter alterations are a prominent pathological feature observed in patients with VCI thought to underlie cognitive impairment. Neuroimaging studies show a positive correlation between the burden of white matter alterations and progressive …
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Mechanisms of vascular cognitive impairment in cerebral small vessel disease and stroke
… blood-brain barrier (BBB) permeability and white matter microstructural damage. This thesis aims to elucidate our understanding of the roles of these mechanisms in CSVD and VCI. Methods: This thesis focusses on two longitudinal studies, the ‘PET-MRI-SVD’ and ‘Rates, risks and routes to …
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The neurofunctional correlates of sentence processing: focus on difficulties of morphosyntactic processing and thematic role assignment in aphasia
Left hemisphere damage is a frequent cause of aphasia. Analyses of deviant linguistic behaviors provide valuable information about the functional architecture of language. Correlating specific language difficulties with damage to the brain helps shed light on the relationships between language and …
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The Neurocognitive Sequelae of Chronic Traumatic Brain Injury and the Utility of Treatment with Methylphenidate
… to MPh treatment. Patients display reduced white matter integrity in regions relevant for specific cognitive domains, disrupted fibre tractography, and compromised axonal projections. These were in the corona radiata, cingulum, and external capsule which connect frontoparietal and …