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Showing 1 to 4 of 4 for “"Wet media milling"”.
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Assessment of nanocomposites vs. amorphous solid dispersions for dissolution enhancement of bcs class ii drugs
… a processing-formulation understanding of wet media milling process for fast-efficient production of drug nanoparticles in stable nanosuspension form, (2) elucidate the impact of various classes dispersants on drug release rate and mechanisms during the redispersion-dissolution of …
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Clarithromycin nanocrystals for high-dose inhalation
… (BCS II) was converted to nanocrystals by wet media milling. Spray-dried hollow microparticles, so called "Trojan particles", in which nanocrystals are incorporated in a matrix shell are designed for deep-lung deposition while retaining good flow and dispersion. Hydroxypropyl …
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Nanosized systems for efficient delivery of antitumoral and anti-inflammatory drugs
… and cellular uptake in hepatoma cells due to the mediating of Lf that could bind to multiple receptors on cell surface such as ASGP-R with high affinity. From our data, emerges that liposome delivery system may insure a specific and sustained drug delivery, a reduced therapeutic dose and, in …
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Batch and continuous production of stable dense suspensions of drug nanoparticles in a wet stirred media mill
… size of drug crystals down to nanoscale via wet stirred media milling. An increase in total surface area per mass loading of the drug and specific surface area as well as reduced external mass transfer resistance allow a faster dissolution of the poorly-water soluble drug from nanocrystals. …