Global ETD Search
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Showing 1 to 20 of 41 for “"Water-soluble drugs"”.
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Solubility enhancement of poorly water soluble drugs using liposome technology
… could control the encapsulation of lipophilic drugs and investigate the influence of the physical properties of poorly water-soluble drugs on bilayer loading. Initial work investigated on the solubilisation of ibuprofen, a model insoluble drug. Drug loading was assessed using HPLC and UV …
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Apparent dissolution rate enhancement of poorly-water soluble drugs by adsorption technique
… chemical entities (NCE’s) discovered are poorly-water soluble drugs and the number of poorly-water soluble drugs are increasing rapidly in the drug discovery. Most of the NCE’s are lipophilic and have dissolution rate issues. Low dissolution rate of the drugs result in poor bioavailability. To …
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Exploring co-milling as a strategy to improve the dissolution of poorly water-soluble drugs
… limitation to the oral absorption of many poorly water-soluble drugs. Co-milling offers a solvent-free and industrially scalable technology to overcome dissolution rate limited absorption. However, its broader application has been constrained by the complexity of mechanochemical transformations, …
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Polymer-bile salts interaction and its impact on the solubilisation and intestinal uptake of poorly water-soluble drugs
I would like to thank my primary supervisor Dr. Sheng Qi for the invaluable support and encouragement received during my PhD time at UEA. Thanks also to my supervisors Prof. Peter Wilde and Prof. Duncan Craig for their help. I would also like to express my gratitude to Prof. Pete Belton, Dr. …
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Investigation of Amorphous Solid Dispersions of Poorly Water-soluble Drugs in Poly (2-hydroxyethyl Methacrylate) Hydrogels for Enhanced Solubility and Controlled Release
… to enhance the dissolution behavior of poorly water-soluble drugs. The first part of the study identifies physicochemical properties affecting the solid state and physical stability of ASD of the model drug indomethacin (IND) in PHEMA hydrogels. The results of the second part show that ASD …
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Preparation and Evaluation of Oil-in-Water Self-Nanoemulsifying Systems with Potential for Pulmonary Delivery
… can drastically improve absorption of poorly water soluble drugs by keeping it in solubilized form at the site of absorption. The objective of the study was to develop a formulation to increase the solubility of poorly water soluble drugs and carbamazepine was selected as a model drug. The …
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A Dual Approach of Salt Formation and Amorphous Solid Dispersion for Improved Oral Drug Delivery
Poorly water-soluble drugs are characterized by their limited dissolution in the gastrointestinal (GI) tract that causes reduced bioavailability and suboptimal therapeutic outcomes. Drug solubility is a crucial factor that influences the absorption and bioavailability of orally administered drugs. …
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The kinetics of drug dissolution in polymers during hot-melt extrusion
… with increased bioavailability for the poorly-water soluble drugs and controlled release characteristics for the water-soluble drugs. In pharmaceutical Hot-melt extrusion poorly water soluble drug particulates are mixed with water soluble polymer excipient particulates and fed in the extruder, …
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Solid dispersions: formulation, characterisation, permeability and genomic evaluation
Poor water solubility is characterised by low dissolution rate and consequently reduced bioavailability. Formulation of solid dispersion of the drug has attracted considerable interest as a means of improving dissolution process of a range of poorly water soluble drugs. This current study …
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IN VITRO ΚΑΙ IN VIVO ΜΕΛΕΤΕΣ ΤΗΣ ΕΠΙΔΡΑΣΗΣ ΤΩΝ ΠΡΩΤΕΙΝΩΝ ΣΤΗ ΔΙΑΛΥΤΟΠΟΙΗΣΗ ΚΑΙ ΑΠΟΡΡΟΦΗΣΗ ΔΙΚΟΥΜΑΡΟΛΗΣ ΝΙΤΡΟΦΟΥΡΑΝΤΟΙΝΗΣ ΚΑΙ ΣΟΥΛΦΑΜΕΘΙΖΟΛΗΣ
… PROTEINS CAN ALTER THE BIOAVAILABILITY OF POORLY WATER SOLUBLE DRUGS (AT CONCENTRATIONS SIMILAR TO THOSE THEY ARE MET IN FOODSTUFFS) WERE INVESTIGATED. NITROFURANTOIN, DICUMAROL AND SULFAMETHIZOLE WERE CHOSEN AS MODEL DRUGS. BOVINE SERUM ALBUMIN AND CASEIN WERE USED AS MODEL PROTEINS. THE IN VITRO …
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Insight into Nucleation Kinetics of Flufenamic Acid Cocrystal Formulation in Solution: Investigating the Role of Polymeric Excipients through Combined Experimental and Computational Approaches
… enhanced solubility and dissolution for poorly water-soluble drugs. However, their dissolution processes often involve complex nucleation and crystallisation dynamics, which can revert the drug to its poorly soluble form. To address these challenges, this study employs a combination of …
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Investigation of Enhancement of Furosemide Solubilization with Cyclodextrins and a Novel Octenyl Succinate Anhydride Starch
… It also looks into the recent poorly water soluble drugs approved by the Food and Drug Administration and the formulation techniques that these drugs used.</p> <p>Chapter 2 is a brief history of solid dispersion, including its theoretical basis, preparation methods, and …
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Formulation and dissolution of polymer strip films for the delivery of poorly water-soluble drug nanoparticles
… of efforts have focused on incorporation of water-soluble drugs. The objective of this dissertation is to explore the robustness and versatility of the strip film platform for delivery of poorly water-soluble drug nanoparticles to ultimately develop a predictive model for drug release from …
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Production of stable bcs class ii drug suspensions by melt emulsification and subsequent incorporation into polymer strip films
… ways to improve the dissolution rate of poorly water-soluble drugs is to produce fine drug particles with increased surface area. This increase will lead to bioavailability enhancement. However, smaller drug particles are thermodynamically unstable and tend to aggregate or grow. Therefore, …
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Dissolution Behavior of Amorphous Solid Dispersions
… drug compounds have extremely poor solubility in water, impacting the bioavailability of the drug. Solubility enhancement techniques, such as amorphous solid dispersions (ASDs), can be used in oral dosage forms to increase the apparent solubility of the drug in the gastrointestinal tract thus …
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Development of Methods to Predict and Enhance the Physical Stability of Hot Melt Extruded Solid Dispersions
… of in-vitro and in-vivo performance of poorly water-soluble drugs. However, because of their meta-stable nature, the physical stability of amorphous solid dispersions has been considered to be the main obstacle for their formulation development and commercialisation by the pharmaceutical …
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Application of Hansen Solubility Parameters and Thermomechanical Techniques to the Prediction of Miscibility of Amorphous Solid Dispersion. Investigating the role of cohesive energy and free volume to predict phase separation kinetics in hot-melt extruded amorphous solid dispersion using dynamic mechanical analyser, shear rheometer and solubility parameters data
… employed to improve the solubility of poorly water-soluble drugs. The technique relies on the enhanced solubility of the amorphous form of the drug compared to its crystalline counterpart. These systems however are thermodynamically unstable. This means that the drug crystallises with time. …
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Mechanistic study of nanoemulsion absorption and its application for permeation enhancement
<p>Oil in water (o/w) nanoemulsion is a two-phase dispersed system in which the oil can incorporate poorly water soluble drugs to form a liquid dosage form. The enhancement of bioavailability with a use of nanoemulsion has often been reported empirically and speculated to be a result of the …
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Cyclodextrin complexes of antimicrobial agents
Poorly water-soluble drugs show an increase in solubility in the presence of cyclodextrins (CyD) due to the formation of a water-soluble complex between the drug and dissolved CyD. This study investigated the interactions of -Cyd and hydroxypropyl--CyD (HP--CyD, M.S. = 0.6) with antimicrobial …
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