Global ETD Search
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Showing 1 to 9 of 9 for “"Warfarin therapy"”.
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The impact of the cytochrome CYP2C9*2 and *3 polymorphisms in the South African Caucasian population on warfarin therapy protocols
Please read the abstract in the section 00front of this document
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Profile and anticoagulation outcomes of patients on warfarin therapy in an urban hospital in Cape Town: a review of records of patients attending Victoria Hospital, Cape Town, South Africa
Background: Warfarin is the most frequently used oral anticoagulant worldwide and it is the oral anticoagulant of choice in South Africa for reducing thrombosis - related morbidity and mortality. However, the safety and efficacy of warfarin therapy depends mainly on careful monitoring and …
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The role of genetic variation in VKORC1 and GGCX on warfarin response in a South African population
Background: Warfarin is the most commonly used drug in the management of thromboembolic disease. However, there is a huge variability in the management of warfarin affecting the international normalized ratio (INR). Many genetic-association studies have reported on European and Asian populations …
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Duration of oral anticoagulation in first-episode idiopathic deep vein thrombosis: A Markov decision analysis.
… were to assess quality of life for patients on warfarin therapy for DVT and for patients with post-thrombosic syndrome. A third objective was to determine if quality of life for these two health states differed between patients and healthy volunteers. Methods. Decision analysis with a Markov …
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International normalised ratio control in a non-metropolitan setting in Western Cape Province, South Africa
… determines the effectiveness and safety of Warfarin. Data on INR control in non-metropolitan settings of South Africa (SA) is sparse. Objectives: To examine the Time in Therapeutic Range (TTR) and its potential predictors in a sample of Garden Route District Municipality INR clinics Methods: …
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International Normalised Ratio Monitoring in Children: Comparing the accuracy of portable point-of-care monitors to standard of care laboratory monitoring at Red Cross War Memorial Children's Hospital
… in the use of long-term oral anticoagulation therapy in children. Monitoring the international normalised ratio (INR) is an integral part in management of these patients, but standard laboratory testing of the INR presents challenges in this age group. Point-of-care INR monitors such as the …
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Poor anticoagulation control in patients taking warfarin at a tertiary and district-level prothrombin clinic in Cape Town, South Africa
Background. Warfarin is the most commonly used anticoagulant for both primary and secondary prevention of thromboembolism. For anticoagulation efficacy, the international normalised ratio (INR) needs to be within the therapeutic range for at least 65% of time on warfarin. Objectives. To describe …
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Personalised warfarin dosing in children after congenital heart surgery using the model-based approach
Oral anticoagulation with warfarin represents a major challenge to successful drug therapy in children. The aims of this study was to investigate the implementation in routine clinical practice, personalised warfarin dosing using a PK/PD model, in children after congenital heart surgery and to …