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Showing 1 to 8 of 8 for “"Warfarin Dosing"”.
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Validation of Criteria Used to Predict Warfarin Dosing Decisions
… clots are often treated with anticoagulants, warfarin is such an anticoagulant. The dose's effect is measured by comparing the time for blood to clot to a control time called an INR value. Previous anticoagulant studies have addressed agreement between fingerstick (POC) devices and the …
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Personalised warfarin dosing in children after congenital heart surgery using the model-based approach
Oral anticoagulation with warfarin represents a major challenge to successful drug therapy in children. The aims of this study was to investigate the implementation in routine clinical practice, personalised warfarin dosing using a PK/PD model, in children after congenital heart surgery and to …
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Data-driven dynamic optimization with auxiliary covariates
… value. In addition, we test our approach on a Warfarin dosing example, and it outperforms the leading alternative methods.
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The role of warfarin pharmacogenomics on the time it takes to reach stable therapeutic International Normalized Ratio (INR) and on warfarin dose required to maintain stable therapeutic INR in Black African and Mixed Ancestry South Africans: a focus on CYP2C9 and VKORC1
Warfarin, the most commonly prescribed anticoagulant, is principally metabolized by cytochrome P450 2C9 which functions by inhibiting the Vitamin K epoxide reductase. Genes CYP2C9 and VKORC1 code for these two proteins, respectively. CYP2C9 and VKORC1 exhibit genetic polymorphisms that have been …
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Advancing precision medicine: harnessing data from diverse sources and individuals to predict medication efficacy and safety.
… disparities in underrepresented populations: warfarin dosing in Minnesota Hmong as an example (Chapter 2 and 3) Warfarin, a commonly prescribed anticoagulant, exhibits highly variable dosing among individuals. Our prior research on Hmong, an underserved and underrepresented East Asian …
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The role of genetic variation in VKORC1 and GGCX on warfarin response in a South African population
Background: Warfarin is the most commonly used drug in the management of thromboembolic disease. However, there is a huge variability in the management of warfarin affecting the international normalized ratio (INR). Many genetic-association studies have reported on European and Asian populations …
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Decision-Making Under Uncertainty: From Theory to Practice
… with a case study on contextual bandits for warfarin dosing where we are concerned with the cost of exploration across multiple races and age groups. Next, we study the classical problem of minimizing regret for multi-armed bandits. In this classic problem, there are several existing policies …
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Pharmacogenomics of warfarin: comprehensive evaluation of important warfarin genomic response factors
Introduction: Warfarin is the most widely prescribed anticoagulant for the prevention and treatment of thromboembolic diseases. However, warfarin use is complicated by its narrow therapeutic range and inter-individual variability in the starting dose required to achieve a stable international …