Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 43 for “"Warfarin"”.
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Pharmacogenomics of warfarin: comprehensive evaluation of important warfarin genomic response factors
Introduction: Warfarin is the most widely prescribed anticoagulant for the prevention and treatment of thromboembolic diseases. However, warfarin use is complicated by its narrow therapeutic range and inter-individual variability in the starting dose required to achieve a stable international …
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Validation of Criteria Used to Predict Warfarin Dosing Decisions
… clots are often treated with anticoagulants, warfarin is such an anticoagulant. The dose's effect is measured by comparing the time for blood to clot to a control time called an INR value. Previous anticoagulant studies have addressed agreement between fingerstick (POC) devices and the …
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Personalised warfarin dosing in children after congenital heart surgery using the model-based approach
Oral anticoagulation with warfarin represents a major challenge to successful drug therapy in children. The aims of this study was to investigate the implementation in routine clinical practice, personalised warfarin dosing using a PK/PD model, in children after congenital heart surgery and to …
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Increasing Inclusion of Participants, Leveraging Gut Microbiomes, and Optimizing Machine Learning Models to Advance Warfarin Precision Medicine
… on an individual pharmaceutical therapeutic, warfarin, we demonstrate idealistic benefits, realistic caveats, and paths to improving the benefits and equity of precision medicine through rigorous research. Anticoagulation therapy with the popular vitamin K antagonist, warfarin, can be …
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The role of genetic variation in VKORC1 and GGCX on warfarin response in a South African population
Background: Warfarin is the most commonly used drug in the management of thromboembolic disease. However, there is a huge variability in the management of warfarin affecting the international normalized ratio (INR). Many genetic-association studies have reported on European and Asian populations …
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Profile and anticoagulation outcomes of patients on warfarin therapy in an urban hospital in Cape Town: a review of records of patients attending Victoria Hospital, Cape Town, South Africa
Background: Warfarin is the most frequently used oral anticoagulant worldwide and it is the oral anticoagulant of choice in South Africa for reducing thrombosis - related morbidity and mortality. However, the safety and efficacy of warfarin therapy depends mainly on careful monitoring and …
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The role of warfarin pharmacogenomics on the time it takes to reach stable therapeutic International Normalized Ratio (INR) and on warfarin dose required to maintain stable therapeutic INR in Black African and Mixed Ancestry South Africans: a focus on CYP2C9 and VKORC1
Warfarin, the most commonly prescribed anticoagulant, is principally metabolized by cytochrome P450 2C9 which functions by inhibiting the Vitamin K epoxide reductase. Genes CYP2C9 and VKORC1 code for these two proteins, respectively. CYP2C9 and VKORC1 exhibit genetic polymorphisms that have been …
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The impact of a direct oral anticoagulant in cardiovascular disease
… possible drug and food interactions compared to warfarin, which may result in improved adherence to treatment and may offset the high retail cost of NOACs. Rivaroxaban 10mg is the only NOAC available on the Maltese National Health Service (NHS) formulary and is not available for cardiology …
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Poor anticoagulation control in patients taking warfarin at a tertiary and district-level prothrombin clinic in Cape Town, South Africa
Background. Warfarin is the most commonly used anticoagulant for both primary and secondary prevention of thromboembolism. For anticoagulation efficacy, the international normalised ratio (INR) needs to be within the therapeutic range for at least 65% of time on warfarin. Objectives. To describe …
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The impact of the cytochrome CYP2C9*2 and *3 polymorphisms in the South African Caucasian population on warfarin therapy protocols
Please read the abstract in the section 00front of this document
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Oral anticoagulation treatment in atrial fibrillation - To bleed or not to bleed, that is the question
… Oral antigoagulation treatment (OAT) with warfarin have a narrow therapeutic window and patients exhibit a highly variable doseresponse that is attributable to genetic, disease-related,and environmental factors as well as prescription and nonprescription drugs, dietary vitamin K and …
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Anticoagulant Treatment Effects Assessment in Antiphospholipid Syndrome Patients Using Targeted Learning and the Oracle Health EHR Data
… health complications and even death. While warfarin has traditionally been the go-to anticoagulant for most patients with APS, many clinicians are now turning to direct oral anticoagulants (DOACs). However, there's still a lot of uncertainty about how effective these newer medications are …
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International normalised ratio control in a non-metropolitan setting in Western Cape Province, South Africa
… determines the effectiveness and safety of Warfarin. Data on INR control in non-metropolitan settings of South Africa (SA) is sparse. Objectives: To examine the Time in Therapeutic Range (TTR) and its potential predictors in a sample of Garden Route District Municipality INR clinics Methods: …
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Does engaging with an interactive adherence intervention improve time in therapeutic range compared to receiving an education intervention alone, among patients anticoagulated with warfarin in Cape Town, South Africa?
Background: Warfarin is the mainstay of oral anticoagulation in South Africa. There is wide variability between individual dose requirements. Regular International Normalised Ratio (INR) monitoring to guide dosing is required. Maintaining INR in therapeutic range is important for efficacy and …
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Contributions to Clinical Dose Individualisation
… how the quality and safety of vancomycin and warfarin treatment may be improved by using model-informed approaches to individualise therapy. In this thesis, models supported by pharmacological theory were implemented in the clinic to inform vancomycin and warfarin treatment. For vancomycin, a …
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Investigating prescribers' experiences of direct-acting oral anticoagulants for the management of nonvalvular atrial fibrillation.
… atrial fibrillation (AF) and have replaced warfarin as the first line agent of choice. The aim of this research was to determine prescribers' views and experiences of the use of DOACs for the management of non-valvular AF. The first phase was a PROSPERO-registered systematic review of …
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A study of the impact of substituting Warfarin with Direct Oral Anticoagulants (DOAC), in Atrial Fibrillation (AF) patients over 65 years old: The Patients’ and Clinicians’ Perspectives.
… with the established oral anticoagulant Warfarin, the newer medication referred to as Direct Oral Anticoagulants (DOACs) was less broadly studied. Importantly, little was known about how patients coped on a daily basis with this new treatment. Furthermore, the practical and social impact …
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Haemorrhage and Other Complications in Pregnant Women on Anticoagulation for Mechanical Heart Valves; a Prospective Observational Cohort Study
… the cardiac-obstetric clinic were screened for warfarin use between 1 July 2010 and 31 December 2015. Of 33 pregnancies identified, 29 were included. Patients received intravenous unfractionated heparin from six to 12 weeks’ gestation and peripartum, and warfarin from 12 to 36 weeks. Maternal …
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Development of guidelines for high-risk medication dispensing
… (n=20) high-risk medications followed by warfarin (n=11) and insulin (n=7). Throughout the dispensing process, all pharmacists (N=50) ensured that patients understood well how to administer the high-risk medication and if they are experiencing any issues. All pharmacists repeated major key …
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