Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 38 for “"Warburg Effect"”.
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Resveratrol slows cell growth by targeting the Warburg effect and stimulating mitochondria metabolism
… been widely studied due to its health promoting effects, which are associated with RES ability to positively impact mitochondria function. Here, I investigated the interaction between RES’s effects on growth and metabolism in PC3 prostate cancer cells and demonstrated that RES-mediated growth …
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Toxoplasma gondii-mediated Host Cell Transcriptional Changes Lead to Metabolic Alterations Akin to the Warburg Effect
… metabolism – that of aerobic glycolysis (the Warburg effect) – in order to satisfy its own energetic and metabolic needs.
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EXPLORING THE ALLOSTERIC INHIBITION MECHANISM OF HUMAN KIDNEY TYPE GLUTAMINASE TO ARREST CANCER CELL PROLIFERATION AND INVESTIGATING HAKAI MEDIATED UBIQUITINATION TOWARDS CONTROLLING CANCER CELL MIGRATION
… Two among them are the altered cell metabolism (Warburg effect), and cancer cell invasion/progression mediated by post-translational modulation of cell signaling. In this thesis we have attempted to explore these two hallmarks towards understanding different avenues to arrest cancer cell growth
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Preclinical evaluation of pharmacological strategies designed to enhance the activity of established and novel anti-cancer drugs. Synopsis: Evaluation of pharmacological strategies designed to modulate the Warburg effect, enhance the activity of tyrosine kinase inhibitors and novel analogues of Temozolomide.
… cells are dependent upon aerobic glycolysis (the Warburg effect) and glutamine uptake. Using clinically approved tyrosine kinase inhibitors and Bortezomib, significant enhancement of chemosensitivity was observed when used in combination with inhibitors of lactate dehydrogenase (Gossypol) and …
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Preclinical evaluation of pharmacological strategies designed to enhance the activity of established and novel anti-cancer drugs. Synopsis: Evaluation of pharmacological strategies designed to modulate the Warburg effect, enhance the activity of tyrosine kinase inhibitors and novel analogues of Temozolomide.
… cells are dependent upon aerobic glycolysis (the Warburg effect) and glutamine uptake. Using clinically approved tyrosine kinase inhibitors and Bortezomib, significant enhancement of chemosensitivity was observed when used in combination with inhibitors of lactate dehydrogenase (Gossypol) and …
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Characterization of Metabolic Differences in Benign, Slow Developing and Tumor Initiating Ovarian Cancers
… can be developed. The Nobel laureate Otto Warburg is credited with discovering an altered metabolic state within cancer cells known as the Warburg effect. In the Warburg effect, cancer cells participate in an increased rate of aerobic glycolysis with an excess secretion of lactate, allowing …
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Suppression of Carcinogenesis and Tumor Progression by an Energy Restriction-Mimetic Agent in Murine Models of Prostate Cancer
… This shift in energy metabolism, termed the Warburg effect, is responsible for cancer cells’ high metabolic rate. Therapies that inhibit cancer cell energy metabolism have proved effective in vitro, and dietary caloric restriction is a valuable experimental chemotherapeutic strategy. While …
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PRUNE_1 INVOLMENT IN TNBC ENHANCING CANCER METABOLISM
… metabolic alterations, including the Warburg effect. Polyphosphates (PolyP) emerge as critical modulators of ATP synthesis through their degradation by Prune1, which facilitates ADP-ATP conversion and supports mitochondrial function under stress. Prune1 overexpression is associated …
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Metabolomic and metabolomic flux studies of the effects of sphingosine kinase inhibitors on prostate cancer cells using high-resolution mass spectrometry as an analytical technique
… analysis was performed to investigate the effect of different sphingosine kinase inhibitors in prostate cancer cells in order to establish the role of SK1 and SK2 in this cancer. Previous studies have shown that the SK1/2 inhibitor, SKi (2-(phydroxyanilino)- 4-(pchlorophenyl)thiazole) …
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EVALUATING THE EFFECTS OF FASTING CONDITIONS IN COMBINATION WITH TEMOZOLOMIDE FOR THE TREATMENT OF GLIOBLASTOMA MULTIFORME
… protein involved in TMZ resistance. Known as the Warburg effect, cancer cells will preferentially oxidize glucose to lactate in glycolysis. This less effective pathway of energy production means cancer cells must uptake significantly greater amounts of glucose to sustain physiological needs. One …
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Application of High-Performance Liquid-Chromatography Mass-Spectrometry Platform to Study Metabolism and Epigenetic Control of Metabolism
… pathway. This phenomenon is known as the Warburg effect. We hypothesize that cancer metabolism is epigenetically regulated. Epigenetics refers to inheritable traits that are not due to alterations in the primary DNA sequence. DNA methylation is an important epigenetic modification. DNA …
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Sunitinib-Induced Cardiotoxicity Exposes Microvascular and Metabolic Derangements In The Failing Heart
… dysfunction is one of the largest obstacles to effective cancer treatment. Not only do a growing number of cancer patients have significant cardiovascular risk factors at the time of diagnosis, but a number of targeted therapies can themselves cause cardiac dysfunction. These newer treatment …
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Identifying The Immune Related Metabolic Properties of Pancreatic Cancer Using Nuclear Magnetic Resonance Spectroscopy and Dynamic Magnetic Resonance Spectroscopic Imaging With Hyperpolarized Pyruvate
… but initial trials in mice have proved ineffective. Because cancer cells exhibit a significant increase in metabolic activity relative to normal tissue, an understanding of the metabolic function of tumors in systems with different levels of immunocompetence is a critical first step to …
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Potential of metabolic MRI to address unmet clinical needs in localised renal cancer.
… regions of varying degrees of perfusion and Warburg effect are present, which differ in aggressiveness. Chapter 2 presents my findings in two clinical scenarios: in a fumarate hydratase-deficient (FHd) renal cell carcinoma (RCC) case, which is a rare but highly aggressive RCC subtype (Chapter …
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Hijacking Cancer Signaling: First-in-class JPRK-targeting Ligands for Fibrolamellar Hepatocellular Carcinoma
… proteomics were performed studies to examine the effects of the ligands, and phosphorylation events on key protein-protein interactions. The JPRK-specific drugs downregulated proteins involved in metabolism and the Warburg effect while upregulating critical epigenetic apoptosis drivers leading to …
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Metabolic Diversity in Human Non-Small Cell Lung Cancer Cells
… of cancer cell metabolism, including the Warburg effect, were observed to span at least a 10-fold range among cell lines grown under identical conditions. Affinity propagation clustering using metabolic features alone produced families that were largely distinct from clusters based solely …
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An Automated Syringe Pump System For Improving The Reproducibility of Dynamic Hyperpolarized Mri Phantoms
… for cancer cells. In this process, known as the Warburg effect, the up-regulation of lactate dehydrogenase leads to the increased chemical conversion of pyruvate to lactate. Due to the conservation of hyperpolarized <sup>13</sup>C-enriched pyruvate’s nuclear spin state through chemical …
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Anti-Insulin Resistance Treatments Suppress Her2+ Breast Cancer Growth Via Altering Metabolism
… resistance treatments can also reverse the Warburg effect by reducing lactate/pyruvate ratio through <sup>13</sup>C-pyruvate imaging. Cell lines isolated from MMTV-ErbB2/<em>Lepr </em><sup>db/db</sup> mice also showed reduced levels of both oxygen consumption and lactate production upon …
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Regulation of Akt ignal transduction by glucose metabolism
… rate in cancer cells, a phenomenon known as the Warburg effect. While the relevance of this effect is unclear, it is partly driven by upregulation of the glycolytic enzyme 6‐phosphofructo‐2‐kinase/fructose‐2,6‐biphosphatase 3 (PFKFB3). Intriguingly, the expression of PFKFB3 in adipocytes is …
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Detecting tumour responses to treatment using metabolic imaging with hyperpolarised [1-13C]pyruvate and 2-([18F]fluoro)-2-deoxy-D-glucose
… treatment regimens and reduce unnecessary side effects and the costs of ineffective therapy. Anatomical changes following treatment are often slow to manifest and are occasionally misleading. Molecular imaging targeting dysregulated metabolic pathways in tumours can facilitate earlier detection …
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