Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 21 for “"Wallerian degeneration"”.
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A DLK And JNK Dependent Axon Self-Destruction Program Promotes Wallerian Degeneration
… sequence of morphological changes termed Wallerian degeneration. It has long been hypothesized that there is an active axonal breakdown program, conceptually similar to apoptosis, which underlies Wallerian degeneration. However, the molecular pathways that accomplish this program in …
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Experimental Modelling and Molecular Mechanisms of Wallerian Degeneration in Traumatic Axonal Injury
… injury mechanism that worsens TAI may be Wallerian degeneration (WD), a cell-autonomous axonal death pathway. The relationship between traumatic axonal injury and WD is poorly characterised. This thesis explores the basic mechanisms by which a physical axonal trauma can lead to WD, and how …
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The Apoptotic and Wallerian Degeneration Pathways Regulate Disease Onset and Progression in the SOD-1G93A Transgenic Mouse Model of ALS
… by progressive muscle denervation, motor axon degeneration and the death of motor neurons. The molecular mechanisms that mediate axon degeneration in ALS remain unknown, but motor neuron cell body death occurs through apoptosis. Genetic deletion of the pro-apoptotic gene Bax delays muscle …
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Vulnerability of ex vivo α-motor nerve terminals to hypoxia-reperfusion injury.
… but, occurs via a mechanism distinct from Wallerian degeneration, as the neuroprotective slow Wallerian degeneration (Wlds) gene did not protect nerve terminals from these pathological changes. I also provide provisional evidence to show that 1A/II muscle spindle afferents and γ-motor nerve …
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The Heparan Sulfate Proteoglycan Perlecan Regulates Axonal and Synaptic Stability
… These phenotypes are not prevented by blocking Wallerian degeneration and are independent of Perlecan’s role in Wingless signaling. Overexpression of Perlecan in motoneurons cannot rescue synaptic retraction phenotypes. Similarly, removing Perlecan specifically from neurons, glia, muscle, fat …
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THE EFFECTS OF NICOTINAMIDE MONONUCLEOTIDE ADENYLYLTRANSFERASE 2 (NMNAT2) ON MOUSE NERVE AND BLADDER DEVELOPMENT
… the most widely studied for its ability to delay Wallerian degeneration. Studies have linked the Nmnat1 portion of the Wlds fusion protein to the majority of its ability to protect axons, but recent work has identified Nmnat2 as the endogenous factor involved in axon maintenance. Our goal is to …
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Diffuse Brain Injury Triggers Ultra-Rapid Perisomatic Traumatic Axonal Injury, Wallerian Change, and Non-Specific Inflammatory Responses
… ultrastructure revealed the initial stages of Wallerian degeneration. Axotomy sites did not internalize pre-injury administered dextran suggesting pathogenesis independent of altered axolemmal permeability. Given the rapidity of perisomatic axotomy, absence of axolemmal permeability may …
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A New Type of Programmed Cell Death in C. Elegans
… for the involvement of autophagic, necrotic, or Wallerian degeneration genes in linker cell death. By ablating cells neighboring the linker cell, and by examining mutants in which the linker cell is abnormally positioned, we demonstrated that the linker cell employs a cell-autonomous program to …
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Deposition of Electroactive Polymers onto Polymer Nanofibers for Nerve Regeneration
… can regenerate after an injury through the Wallerian degeneration process, the degree of regeneration is often not efficient enough to achieve full return of functionality. To overcome the disadvantages of current nerve repair approaches, peripheral nerve tissue engineering strategies have …
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Exploring SARM1 as a target to delay programmed axon degeneration
Programmed axon degeneration (Wallerian degeneration) can occur after physical injury, inhibition of axon transport, exposure to neurotoxic compounds, and in diseases involving mitochondrial or metabolic dysfunction. There is increasing evidence that this pathway can be activated in human painful …
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Axon Degeneration and the Schwann Cell Early Injury Response: A Study in Mouse and Zebrafish
… axons degenerate through a process termed Wallerian degeneration and Schwann cells transform into a repair phenotype. Axon degeneration is regulated by a signalling pathway controlled by the pro-degenerative axon death molecule sterile-alpha and toll/interleukin 1 receptor motif containing …
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Systemic AAV-Mediated Gene Therapy Using Epo-R76E to Protect Retinal Ganglion Cells from Optic Nerve Injury and Disease
… degenerating neurons in an induced model of neurodegeneration and a spontaneous model of glaucoma.</p> <p>Optic nerve crush is a model of retinal ganglion cell (RGC) death. Crushing the optic nerve causes the axons to undergo Wallerian degeneration and apoptotic loss of retinal ganglion cells over …
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Investigating novel therapeutic approaches and targets to prevent synapse degeneration
… therapies aimed at preventing or halting neurodegeneration. Despite the continuously growing body of research elucidating the molecular mechanisms that modulate synaptic function and vulnerability, the contribution of these pathways to neurodegenerative diseases is far from fully characterized. …
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Contribution of microglial reactivity to olfactory ensheathing cell migration in vivo
… experiments determined the time-frame in which Wallerian degeneration (WD) induced microglial reactivity occurs in the right dorsal corticospinal tract (dCST) of adult rats at the level of T11 following aspiration of the contralateral sensorimotor cortex. This timing data from this study …
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Mutational and Structural Investigation of SARM1, a Protein that Mediates Axon Loss
… NADase that executes the programmed axon degeneration pathway after nerve injury and in diseases including polyneuropathies. The ARM domain of SARM1 plays a crucial role in regulating its NADase activity. By attenuating this activity, axon degeneration is delayed, making SARM1 an important …
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Chronic activation and downstream mechanisms of programmed axon death
… a conserved, well-characterised pathway of axon degeneration activated by physical injury and in disease states. The two main regulators of the pathway are the pro-survival NAD-synthesising enzyme NMNAT2, and the pro-degenerative NAD(P)-consuming enzyme SARM1. Over-expression of NMNAT enzymatic …
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Programmed axon death as a driver of environmental neurotoxicity triggered by pyridine derivatives
… preventable pathway leading to axon degeneration. Programmed axon death is regulated by SARM1, a pro-degenerative, multi- functional enzyme that consumes NAD and NADP, with dramatic consequences for neuron energy metabolism. Accumulating evidence in both pre-clinical disease models …
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Die Rolle des Interleukin-6 bei der Wallerschen Degeneration
Die Rolle des Interleukin-6 bei der Wallerschen Degeneration. Untersucht wurde mit Hilfe von Interleukin-6 Knockout Mäusen die Rolle des Interleukin-6. Am Modell der Axotomie 4- und 6-Tage nach Axotomie des N. ischiadicus im Vergleich zu Wildtyp-Mäusen. Untersucht wurden immunhistochemisch die …
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