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Showing 1 to 2 of 2 for “"Waixenicin A."”.
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Pharmacophore-directed retrosynthesis (PDR) and Density functional theory studies applied to the potent ion channel inhibitor waixenicin A : synthetic studies toward a more stable salarin C congener, thia-salarin C, through the lens of PDR.
Waixenicin A (WaixA) exhibits potent (615 ± 121 nM) and highly selective inhibition of transient receptor melastatin 7 (TRPM7) over closely related ion channels. Thus, WaixA serves as a potential drug lead for the treatment of hypoxic-ischemic brain injury (HIBI) and a compelling target for …
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Role of Ion Channels in Glioblastoma
… potential of the specific TRPM7 antagonist waixenicin A. By employing both in vitro and in vivo approaches, I provided evidence suggesting that waixenicin A reduced GBM cellular functions. Lastly, in my third aim, I expanded my scope of study in order to gain a broader understanding of ion …