Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"WWOX"”.
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The genetic and biochemical analysis of Drosophila Wwox protein function.
WWOX (WW domain-containing oxidoreductase) is a candidate tumor suppressor gene that has been shown to be involved in various cancers including breast, lung, prostate, gastric and hepatic. The Drosophila ortholog Wwox was identified and subjected to targeted ‘loss of function’ mutagenesis. The …
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Defining the role(s) of non-classical tumour suppressor Wwox in cellular function using Drosophila melanogaster genetic modelling
The WWOX gene has been identified as the gene that spans the FRA16D common chromosomal fragile site (CFS), which is a frequent site of DNA instability in cancer. Perturbation of the WWOX gene has been reported in various cancers, with low WWOX levels correlating with poorer prognosis. Individuals …
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Genes: Multigene Families, Control of Gene Expression, Genetic contributions to Human Diseases, including Chromosomal Fragile Sites and ‘Dynamic’ and ‘Non-self’ Mutations
… pathogenic mechanisms of the protein WWOX in cancer and expanded repeat RNAs in neurodegenerative diseases. The culmination of this recent work is the development of an hypothesis – 4. that expanded repeat double-stranded RNA leads to neurodegeneration through its recognition by the …
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Social-Demographics, Health Behaviors, Telomere Length In Mexican-American Cohort and Circulating Dna Methylation In Bladder Cancer
… selected CpG sites, located in genes of TTC23, WWOX, ZNF624 and LOC2211122, respectively. Unfortunately, none of these 4 sites exhibited differential methylation between cases and controls in this validation. Interestingly, there was a SNP rs8038732 (G>A) in the methylation site of gene TTC23. …