Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"WNT/b-catenin"”.
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Wnt-/beta- Catenin Zielgene der frühen Mausentwicklung
… Arbeit wurden entwicklungsrelevante Zielgene der Wnt-/b- Catenin- Kaskade identifiziert. <br>Es wurde ein Zellkultursystem etabliert, mit dem es möglich war, unter einfachen experimentellen Bedingungen, die Wnt- Kaskade in Zellen induzieren zu können. Für das benutzte Zellkultursystem aus …
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EPIGENETIC MECHANISMS OF POLYCOMB REPRESSIVE COMPLEX 1 IN INTESTINAL LINEAGE COMMITMENT
… normal tissue homeostasis by preservation of the WNT/B-catenin activity (4). However, the contribution of PCGFs in adult intestinal homeostasis is unclear. To address this, we evaluated the role of six different PRC1 subcomplexes in transcriptional repression maintenance in intestinal cells by …
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Ancient origins of the chordate forebrain: Conserved patterning of the anterior neuroectoderm in amphioxus
… echinoderms and hemichordates, are regulated by Wnt/b-catenin signalling and are active in the anterior neuroectoderm that forms the larval brain. As a comparative system, I also characterize the development of the apical organ in an understudied group of echinoderms, the crinoids. To follow the …
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The role of Wnt signalling during embryonic salivary gland development
… spreads distally. We looked at the function of Wnt signaling during embryonic development of the submandibular and sublingual salivary glands and found that FGF signaling acts upstream of Wnt signaling and that Wnt and FGF signals coordinate branching morphogenesis and lumen formation. To locate …
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NEU4L INDUCES ALTERATIONS ON CELL PROLIFERATION AND DIFFERENTIATION IN NEUROBLASTOMA CELL LINE, SK-N-BE
… were associated to a marker activation of Wnt/-Catenin pathway, a well-known regulator of proliferation and self-renewal in many cell types. We assessed an increased content of intracellular, not phosphorylated -Catenin (+30%) in Neu4L over-expressing SK-N-BE cells. In parallel, the main …
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IDENTIFICATION AND CHARACTERIZATION OF THE 'GUT VASCULAR BARRIER'
… cingulin) and AJs (VE-cadherin and junctional β-catenin), indicating the presence of a barrier that excludes bacteria from passing through the paracellular route. In addition, we observed the existence of a “gut vascular unit” (GVU) whereby ECs were associated with enteric glial cells and …
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DISSECTING THE ROLE OF Β-CATENIN AND MYC IN GASTRIC TUMOR FORMATION
… of distinct gene-expression programs. The Wnt signaling pathway plays a prominent role in regulating the homeostasis of gastrointestinal epithelium by promoting stem cell maintenance, proliferation and cell fate specification. Aberrant activation of the Wnt/β-catenin signaling pathway …