Global ETD Search
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Showing 1 to 16 of 16 for “"WNK"”.
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Identifying Novel Functions of the WNK Pathway
The with no lysine [K] (WNK) pathway consists of WNK kinases, their downstream target kinases, oxidative stress responsive (OSR)1 and SPS/Ste20-related proline-alanine-rich kinase (SPAK), and OSR1/SPAK substrates, cation chloride cotransporters. The pathway regulates ion transport across cell …
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WNK Family Kinases and the Regulation of Ion Flux
… mammalian examples of the with no K (lysine) or WNK family of serine/threonine protein kinases have an unusual arrangement of their catalytic lysines. WNK1 and WNK4 have been genetically linked to a rare type of hypertension. Studies demonstrate that these kinases regulate the activity of a …
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Regulation of Endocytosis of ROMK Channel by WNK Kinase Family
WNK kinases are members of a novel family of serine/threonine kinases with atypical placement of the catalytic lysine. Mutations in WNK1 and WNK4 cause pseudohypoaldosteronism type 2 (PHA2), an autosomal-dominant disease characterized by hypertension and hyperkalemia. Renal outer medullary …
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With No Lysine (WNK) Family Proteins and Their Interaction with Downstream Kinases
With no lysine (WNK) kinases are a family of protein kinases characterized by unusual kinase domain architecture. These large proteins, divergent outside of a kinase core and protein-protein interaction motifs, have been associated with pseudohypoaldosteronism 2, a form of Mendelian-inherited …
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Regulation and Dysregulation via Docking Interactions in WNK and ERK1/2 MAPK Signaling
… two independent cellular signaling pathways, the WNK, and ERK1/2 MAPK pathways. The WNK pathway is an essential regulator of cellular ionic composition and volume. Initially discovered due to the genetic link between mutations in some of the WNK kinases and an inherited form of hypertension, the …
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Search for Insulin Secretion Modulators, Novel Functions of WNK Signaling and Intramolecular Signal Transduction in ERK2
… of insulin secretion from pancreatic beta cells, WNK1 pathway involvement in cell migration, angiogenesis, breast cancer, and other processes, as well as ERK2 intradomain communication are discussed. Each chapter is dedicated to a separate project, but the common denominators for these projects …
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Structural Analysis of STE20-Related Proline-Alanine-Rich Kinase (SPAK)
… SPAK was identified as a target regulated by the WNK (With No lysine (K)) family of protein kinases. Overexpression of WNK1 has been associated to a hereditary form of hypertension. The link between WNK-SPAK-cotransporters provides one of the functional pathways for WNK to regulate intracellular …
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Gitelman & Gordon: Mirror image syndromes reveal the roles of WNKs in blood pressure homeostasis and novel anti-hypertensive targets
… (GS) syndromes revealed the importance of the WNK pathway and thiazide-sensitive Na-Cl Cotransporter (NCC) in the renal control of blood pressure. PHAII mutations lead to WNK accumulation resulting in the hyperphosphorylation of the downstream effector, SPAK, which overactivates NCC causing …
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Identification of Substrates and Pathways Regulated by WNK1
WNK (With No lysine (K)), a serine/threonine protein kinase, is a unique molecule not belonging to any other canonical protein kinase family including mitogen-activated protein (MAP) kinases. The name of the WNK protein kinase family reflects the fact that a catalytic lysine lies in a position …
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Interaction Mapping of the Atypical Protein Kinase WNK3
… story of the protein kinase "with no lysine 3" (WNK3) represents a unique chapter in the larger story of protein kinases, the so-called 'molecular switches' of the cell that serve the vital function of phosphorylating myriad proteins. In doing so, these enzymes furnish the cell with one of the …
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With No Lysine 1 (WNK1): A Potential Regulator of The Lysosomal Degradation Pathway
With no Lysine (K) 1 (WNK1) is an atypical serine/threonine protein kinase that has its catalytic lysine positioned in a unique location. This kinase, along with another member of the WNK family, WNK4, has been genetically linked to pseudohypoaldosteronism type II (PHAII), which is characterized by …
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Physiological and pharmacological factors affecting sickle cell function
… of the pan “with no lysine” kinase inhibitor WNK463 on KCC activity in HbSS RBCs, indicative of a critical role for WNK kinases in control of KCC in RBCs. However, there was no pharmacological evidence for the downstream involvement of SPAK/OSR1, although definitive evidence awaits …
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Investigating the Biological Functions of the Protein Kinase WNK1 in the Regulation of Cytoskeletal Structures and Membrane Trafficking
With No Lysine (WNK) 1, a serine/threonine kinase, is a unique kinase to its catalytic lysine residue at a non-canonical position relative to all other kinases. Characterization of endogenous WNK1 distribution by immunofluorescence reveals a perinuclear punctate pattern. I have investigated this …
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Understanding Potassium Homeostasis Using Human and Mouse Genetic Models
… by mutations on with-no-lysine kinase 1 or 4 (WNK1/4) and featured with hyperkalemia and hypertension. Studies in PHA2 have revealed that WNK kinases regulate renal sodium transporters and potassium channels. WNK1 enhances the endocytosis of renal outer medullary potassium (ROMK) channel …
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In vivo Genome-wide Expression Study on Human Blood B cells Suggests a Novel ESRI and MAPK3 Network for Postmenopausal Osteoporosis
… STK11 (serine/threonine kinase 11), WNKI (WNK lysine deficient protein kinase 1), and ZNF446 (zinc finger protein 446). This is the first in vivo genome-wide expression study on human B cells for osteoporosis. My results suggest a novel mechanism for postmenopausal bone loss that …
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Investigating KCC2 activity in Amyloid Precursor Protein (APP) associated Alzheimer’s Disease
One of the hallmarks of AD is the formation of sticky protein clumps in the brain known as amyloid-beta (Aβ) plaques, which are formed from specific fragments of the amyloid precursor protein (APP). The intact form of APP is essential for synaptic function; however, much remains to be explored …