Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 13 of 13 for “"WGCNA"”.
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Bioinformatics e Biostatistics applied to research in pediatric genetic disease. Clinical evidence in IFNλ4 polymorphisms associated with HCV infection in patients with beta thalassemia and WGCNA analysis weighted for IFNλ4 genotype rs12979860 to detect RPL9P18 as hub in HCV infected cell.
… using weighted gene expression network analysis (WGCNA - R package). Significant modules were selected using the clustering analysis. At the final the best significant module was “black” module. Its pathways were involved in translation mechanisms such as translation termination, translation …
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A multidisciplinary investigation into the function of NFXL1
… Weighted gene co-expression network analyses (WGCNA) in human, mouse, and Drosophila datasets revealed conserved roles in transcriptional regulation, RNA processing, and protein modification. Cell type-specific roles were observed in mice, with Nfxl1 implicated in mitochondrial regulation in …
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Transcriptional variation in muscle from cattle with alternative NCAPG/LCORL QTL genotypes
… weighted gene co-expression network analysis (WGCNA) revealed eleven co-expression gene network modules significantly correlated with genotype. Of these, the LCORL containing module (Blue) showed the highest positive correlation. Gene Ontology enrichment analysis and Ingenuity Pathway Analysis …
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Investigating CD8+ T-cell gene expression signatures as disease prognostic biomarkers in paediatric inflammatory bowel disease.
… Weighted Gene Co-expression Network Analysis (WGCNA) to test for correlations between gene expression data and clinical outcome parameters. Survival analysis (kaplan meyer) was used to compare patient groups for disease outcomes, including number of treatment escalations, use of biologic …
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Defining a Neuroprotective Pathway for the Treatment of Ataxias
… Weighted Gene Co-expression Network Analysis (WGCNA) performed on cerebellar RNA-seq data from ATXN1[30Q]D776;Cck-/- mice identified a disease progression-related gene set named the Pink Module that is influenced by Cck. A Cck1R agonist, A71623, was administered via osmotic minipump to …
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Develpment of soybean knowledge base for systems biology studies
… the weighted gene correlation network analysis (WGCNA). These visualization and analytical tools provide soybean scientists an integrated and systematic manner to view their data and hypotheses on a higher level. Also, an automated soybean genome upgrade system was developed to synchronize with …
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Network Analysis to Identify Biological Pathways Associated with Lyme Disease
… used Whole Genome Correlation Network Analysis (WGCNA) along with univariate analysis and enrichment analysis to identify potential pathways of interest generating novel hypotheses for the underlying mechanisms of LD. I identified specific T-Cell-based inflammatory, arthritic and neurological …
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CRSPR manipulation and nutritional status reveal functions of transcription factor NF-kappaB in the sea anemone Nematostella vectensis
… Weighted Gene Correlation Network Analysis (WGCNA) identified significantly correlated gene networks that were downregulated following starvation, and also identified candidate NF-κB target genes. Previous work has shown that NF-κB signaling plays a role in Nematostella development, however, …
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Understanding factors that affect gene co-regulation patterns
… weighted gene co-expression network analysis (WGCNA) and differential co-expression analysis were powerful alternatives to find more answers about complex systems. Differences in gene expression correlation across treatments and lines helped to understand changes in connectivity associated with …
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Transcriptional regulation of glycosyltransferase genes in MCF-7 human breast cancer cell line following drug treatment
… Weighted Gene Co-Expression Network Analysis (WGCNA) package on each of the cancer and non-cancer drug treatments. The gene modules discovered from the analysis were used to perform gene ontology enrichment analysis to identify the biological functions where they were significantly enriched in. …
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Investigation of the TNF superfamily of ligands as potential therapeutic targets in inflammatory bowel diseases
… weighted gene co-expression network analysis (WGCNA) of microarray data from HT-29 cells treated with IFN-γ and TNF-α, we identified gene modules that suggested both cytokines can cross regulate components of each other’s receptor-mediated signalling pathways. We confirmed these results through …
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Network-based approaches towards understanding the emergence of neurodevelopmental disorders
… weighted gene co-expression network analysis (WGCNA) to identify modules of co-expressed genes and assess their associations with psychiatric diagnosis and toxicological exposures. While several modules were linked to diagnostic status, many were confounded by environmental variables such as …
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Transcriptomic and proteomic dysregulation in neuropsychiatric disorders
… Weighted gene co-expression network analysis (WGCNA) of these datasets implicated gene modules related to response to wounding, nitrogen catabolism, and protein localisation as different between female MDD and CNT samples. MDD subgroups were identified using a data-driven approach, however, …