Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"WEE1 inhibitor"”.
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Mathematical Modeling Reveals That G2/M Checkpoint Override
… TSC2-null cells were more sensitive to the WEE1 inhibitor, a negative regulator of mitotic entry, compared to wild-type cells.</p> <p><strong> In summary</strong>, we reported a novel mechanism of the mTORC1 signaling in regulating a transcriptional program required for G2/M checkpoint …
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Mathematical Modeling Reveals That G2/M Checkpoint Override Creates A Therapeutic Vulnerability In Tsc2-Null Tumors
… TSC2-null cells were more sensitive to the WEE1 inhibitor, a negative regulator of mitotic entry, compared to wild-type cells.</p> <p><strong> In summary</strong>, we reported a novel mechanism of the mTORC1 signaling in regulating a transcriptional program required for G2/M checkpoint …
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Mathematical Modeling Reveals That G2/M Checkpoint Override Creates A Therapeutic Vulnerability In Tsc2-Null Tumors
… TSC2-null cells were more sensitive to the WEE1 inhibitor, a negative regulator of mitotic entry, compared to wild-type cells.</p> <p><strong>In summary</strong>, we reported a novel mechanism of the mTORC1 signaling in regulating a transcriptional program required for G2/M checkpoint …
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Identification Of Effective New Drugs Combinations Exploiting The Ability Of trabectedin To Modulate Transcription
… its activity could be increased by checkpoint inhibitors. The studies performed on the combination of trabectedin and the WEE1 inhibitor, AZD-1775, have shown that the inhibition of WEE1 enhances the trabectedin activity, thus the combination is synergic. Since trabectedin affects the …
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Identifying Mechanisms Of Resistance And Potential Therapeutic Targets For Pediatric Acute Myeloid Leukemia
… of Meg-01 cells with the histone deacetylase inhibitor valproic acid resulted in down-regulation of both GATA1 and Bcl-xL and significantly enhanced ara-C sensitivity. Furthermore, additional GATA1 target genes were identified by oligonucleotide microarray and ChIP-on-Chip analyses.</p> …
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THERAPEUTIC POTENTIAL OF TARGETING THE FLNA-REGULATED WEE1 KINASE PATHWAY IN ADRENOCORTICAL CARCINOMAS.
… 1 receptor (IGF1R) signalling. Upregulation of Wee1 nuclear kinase, a key regulator of G2/M cell cycle checkpoint, was shown in mouse neural progenitor cells lacking FLNA, and it has been reported in several cancers. The first part of this PhD thesis is focused 1) on the analysis of Wee1 …