Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 105 for “"WD"”.
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Role of WD domain-containing proteins in cell cycle progression
In the eukaryotic proteome, WD domain is one of the most abundant protein motifs. The structure of WD domain allows it to interact with diverse protein partners and proteins containing WD domain have been shown to function in various cellular processes. In this thesis, I describe how two WD …
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Validating the WD Repeat Protein CDC40 as a Potential Therapeutic Target for Lung Cancer
Lung cancer is the second most diagnosed and most lethal cancer globally. Presently, there is a need for novel targets for the development of improved therapeutics. Data mining of whole genome genetic dependency screens suggested that the pre-mRNA splicing factor Cell Division Cycle 40 (CDC40) is …
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OPTICALLY-INDUCED POPULATION DISCHARGE THRESHOLD TESTING: A NOVEL INVESTIGATION OF A MURINE MODEL OF ALCOHOL WITHDRAWAL INDUCED CNS HYPEREXCITABILITY
… to problems associated with alcohol withdrawal (WD). During WD the central nervous system (CNS) is described as being hyperexcitable. Hyperexcitability is a consequence of homeostatic pressure to compensate for alcohol’s potentiation of inhibitory systems. When the drug is removed from the system …
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Experimental Modelling and Molecular Mechanisms of Wallerian Degeneration in Traumatic Axonal Injury
… that worsens TAI may be Wallerian degeneration (WD), a cell-autonomous axonal death pathway. The relationship between traumatic axonal injury and WD is poorly characterised. This thesis explores the basic mechanisms by which a physical axonal trauma can lead to WD, and how modulation of the WD …
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Orbifold points on Teichmüller curves and Jacobians with complex multiplication
… 5 with D =/- 0 or 1 mod 4, the Weierstrass curve WD is an algebraic curve and a finite volume hyperbolic orbifold which admits an algebraic and isometric immersion into the moduli space of genus two Riemann surfaces. The Weierstrass curves are the main examples of Teichmüller curves in genus two. …
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A STUDY ON THE EFFECTS OF CHRONIC ALCOHOL AND WITHDRAWAL IN THE BASOLATERAL AMYGDALA OF SPRAGUE DAWLEY RATS: AFFERENT SPECIFIC MODIFICATION OF GLUTAMATERGIC NEUROTRANSMISSION
… ethanol exposure (CIE) and withdrawal (WD). The current studies indicated that EC-BLA and IC-BLA inputs into the BLA can be electrically isolated in an electrophysiological slice recording setup, and remain isolated in the face of CIE and WD. These data allowed the characterization of …
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Doença de Whipple e endocardite tricúspide: um relato de caso
Whipple’s disease (WD) is a rare condition of multiple clinical manifestations and difficult diagnosis. Despite being a disease of insidious evolution, it is frequently neglected and, if not treated, can progress with important sequelae and even death. Diagnosis of WD depends on clinical suspicion, …
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Mechanisms of Western-Diet Induced Endothelial Stiffening: Endothelial CD36 and Long-Chain Fatty Acids
Western diet (WD) refers to a diet high in saturated fat and refined carbohydrates. WD is known to be detrimental to cardiovascular health. These studies present novel insights into the mechanism undergirding WD-associated cardiovascular dysfunction: stiffening (an increase in the elastic modulus) …
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The behavior of hydrogen and helium at white dwarf photosphere conditions
White Dwarfs (WDs) represent the evolutionary endpoint for nearly all stars in the universe. Their atmospheres are usually dominated by either hydrogen, helium, or carbon. In astrophysics, WDs are used to determine the age of the universe, to test current stellar evolutionary models, and to …
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An exploration of workforce diversity management principles & practices in nursing homes
… lack of research related to workforce diversity (WD) specifically in nursing homes. However, there is a need to understand how WD manifests in nursing homes because nursing homes have several distinct characteristics that are unlike other organizations. The study sought to explore WD among nursing …
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Sedentary Behavior in Honors College Freshmen
… time spent in nine SB on a typical weekday (WD) and weekend day (WED). Participant data was examined by WD and WED and gender by using paired sample t-tests, and independent sample t-test. Descriptive statistics are presented means ± standard deviations. Results: There were sixty participants …
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Evolutionary Winner Determination in Advanced Combinatorial Reverse Auctions
… of CRAs increases. Winner Determination (WD) is one of the main challenges of CRAs, and which has been shown to be NP-complete. Researchers limit the auction features because of the issue of time efficiency. We address several types of advanced CRAs by varying the auction parameters. We …
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Circadian Secretion of Glucagon-like Peptide-1
… elusive. Thus, I hypothesized that western diet (WD)-feeding disrupts L cell clock (Bmal1) function thereby impairing rhythmic GLP-1 secretion and diurnal glycemic homeostasis. Use of Bmal1 knockout mice and ex vivo cultures demonstrated the essential role for the clock (Bmal1) in regulating GLP-1 …
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MODULATION OF TRPML1/TFEB PATHWAY FOR THE TREATMENT OF WILSON DISEASE
Wilson disease (WD) is an autosomal recessive disorder characterized by toxic copper accumulation in several tissues, resulting in hepatic and neurological impairment. WD is caused by mutations in the P-type ATPase copper transporting B (ATP7B) gene, responsible for copper supply to cuproproteins …
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Elucidation of the roles of PTN and ISG15 in RSV cytopathogenesis: possible biomarkers of severe disease?
… paediatric nasal epithelial cell cultures (WD‐PNECs), provides a reasonable surrogate for in vivo responses. Because of the strong association of severe RSV disease with prematurity and young age, the first part of this thesis describes the utilisation of the WD‐PNEC model to establish and 6 …
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A Study on the Effects of Chronic Alcohol and Withdrawal on the Glutamate, GABA, and Dopamine Systems in the Basolateral Amygdala of Sprague Dawley Rats
… intermittent ethanol (CIE) and withdrawal (WD) on glutamatergic synaptic transmission in the BLA. This set of studies suggests that glutamatergic function is increased at BLA synapses in CIE and WD treated animals, albeit via distinct mechanisms. Furthermore, we found that manipulations of …
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Observational studies of highly evolved cataclysmic variables
… star transfers mass onto a white dwarf (WD). According to standard evolutionary theory, angular momentum loss drives CVs to initially evolve from longer to shorter orbital periods until a minimum period is reached (? 80 minutes). At roughly this stage, the donors becomes degenerate, …
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Chromatophore tissue density and skeletal density banding as a measure of the adaptive response of healthy corals to environmental change
… bathymetric transect of increasing water depth (WD) and decreasing photosynthetically active radiation (PAR). This has established the first qualitative and quantitative baseline for the extent to which apparently healthy corals respond to changes in WD and PAR, thus creating a comparative …
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Reducing the Compositional and Structural Degeneracy of Planetary Interiors
… for hypothetical Earth-like white dwarf (WD) exoplanets, reducing interior degeneracy for these planets. However, I also identify a novel carbon-rich interior composition for sub-Neptunes, introducing an additional degeneracy to this already ambiguous category. It is heatedly debated that …
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