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Showing 1 to 1 of 1 for “"WARS1"”.
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Characterizing CMT-causing variants in tryptophanyl- tRNA synthetase
… in the human tryptophanyl-tRNA synthetase (WARS1). Using proteomic analysis, protein biochemistry, and yeast growth assays, I found that while both variants retain their typical structure, their stability and function differ. D314G exhibited decreased stability and triggers stress- related …