Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 7 of 7 for “"Vulval development"”.
-
Characterization of the class A synthetic Multivulva genes, which act in C. elegans vulval development
… function redundantly to inhibit Ras-mediated vulval development in C. elegans. The class B synMuv genes encode an Rb/DP/E2F repressor complex that likely silences genes required for vulval specification through chromatin modification and remodeling. Rb has been extensively characterized as a …
-
Rb pathway and chromatin remodeling genes that antagonize let-60 Ras signaling during C. elegans vulval development
… B genes act redundantly to regulate Ras-mediated vulval cell fate specification in the nematode Caenorhabditis elegans. The class B synMuv gene lin-35 encodes a protein similar to the mammalian pRb tumor suppressor protein. The LIN-35 Rb protein is proposed to act with HDA-1, a histone deacetylase …
-
The C. elegans class A synthetic multivulva genes inhibit ectopic RAS-mediated vulval development by tightly restricting expression of lin-3 EGF
… antagonize an EGF/Ras pathway to prevent ectopic vulval induction. The class B synMuv genes encode many proteins known to remodel chromatin and repress transcription. The class A synMuv genes likely also function in transcription, although their specific molecular functions are unknown. We have …
-
The genetic analysis of the vulval cell lineages of Caenorhabditis elegans
… lineage, that of the hermaphrodite vulva. During vulval development, six equipotentlal cells of the ventral hypodermis respond to an inductive signal from the gonadal anchor cell to adopt one of three fates dependent upon position. Thus, the vulva is a model system to study the processes of …
-
LDB-1 AND SWI/SNF CHROMATIN REMODELING COMPLEX PARTICIPATE IN THE TRANSCRIPTIONAL ACTIVATION BY C. ELEGANS BLIMP1/PRDM1
… of bed-3, a gene required for molting and vulval development, providing the first evidence that BLMP-1 can act as a transcriptional activator in C. elegans. To study the role of BLMP-1 as a transcriptional activator, we performed a RNAi screen and identified three possible interacting …
-
Temporal control of vulval precursor cell fate patterning in Caenorhabditis elegans
Development of a multicellular organism requires precise coordination of temporal and spatial cues to ensure that developmental events occur at the correct time and place. C. elegans vulval development offers a convenient experimental system for investigating the temporal and spatial regulation of …
-
blmp-1 is a Ras-cooperating Tumor Suppressor Gene in Caenorhabditis elegans
… mutations have 60 - 80% penetrant visible multivulval (Muv) phenotype. Several suppressors and enhancers of this phenotype have been shown to be orthologous to Ras-cooperating proto-oncogenes and tumor-suppressor genes, respectively. Because several epigenetic regulators are now targets of …