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Showing 1 to 2 of 2 for “"Vps54"”.
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The Role of Vps54 in Drosophila melanogaster Neuronal Development and Age Progressive Neurodegeneration
<p>Vps54 is a subunit of the Golgi-associated retrograde protein (GARP) complex, which is involved in tethering endosome-derived vesicles to the trans-Golgi network (TGN). The “wobbler” mouse is the phenotypic result of a destabilizing point mutation in Vps54. This mutation causes neurodegeneration …
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Identifizierung und Charakterisierung des krankheitsauslösenden Gens in einem Mausmodell für humane Motoneuronerkrankungen
… region. The discovery of a point mutation in Vps54 led finally to the breakthrough. The Wobbler phenotype could be compensated by the transgenic overexpression of Vps54. This result proved the identity of wr. Possible interaction partners for Vps54 could be identified by the yeast two hybrid …