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Showing 1 to 20 of 26 for “"Von Willebrand Factor (VWF)"”.
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Understanding the Role of von Willebrand Factor (VWF) in Angiogenesis and Angiodysplasia
von Willebrand factor (VWF) is a large multimeric glycoprotein essential for hemostasis, mediating platelet adhesion to sites of vascular injury and stabilizing coagulation factor VIII (FVIII) in circulation. Deficiency or dysfunction of VWF results in von Willebrand disease (VWD), the most common …
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The role of von Willebrand factor and its cleaving protease, ADAMTS13, in young patients with HIV-related stroke.
… uncommonly seen in young adults. High levels of von Willebrand factor (VWF), a protein with key roles in platelet adhesion and aggregation, and low levels of A Disintegrin and Metalloproteinase with a Thrombospondin type 1 motif, member 13 (ADAMTS13), the protease that cleaves ultra large VWF …
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A genome-wide association study in chronic thromboembolic pulmonary hypertension and the ADAMTS13-VWF axis
… of thrombus resolution. Identifying genetic risk factors for CTEPH would provide important insights into pathobiology and might allow risk-stratification following PE. A genome-wide association study (GWAS) was performed in 1250 CTEPH patients, 1492 healthy controls and ~7 million …
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Determination of ADAMTS13 Susceptibility in Type IIA von Willebrand Disease
<p>von Willebrand Disease (vWD) is a bleeding disorder caused by a deficiency in von Willebrand Factor (vWF), a large glycoprotein that assists in coagulation. Specifically, large vWF multimers in the blood stream are key components in starting the coagulation cascade. vWF is cleaved by the …
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Multi-scale computational modeling of particle adhesion dynamics under shear flow
… simulation, a physical description of the von Willebrand factor (VWF) mediated thrombus growth process was formulated. The physics-based model captures distinct stages of the thrombus growth process in shear-induced platelet adhesion (SIPA) and platelet-aggregate morphology. It describes …
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Effect of Levothyroxine Administration on Hemostatic Analytes in Doberman Pinschers with von Willebrand's Disease
… levothyroxine supplementation increases plasma von Willebrand factor (vWf) concentration and enhances vWf function. The effects of levothyroxine administration were evaluated in 8 euthyroid Doberman Pinschers with plasma vWf concentration <30%. Levothyroxine (0.04mg/kg PO q12hours) and placebo …
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Platelet Function in Dogs with Chronic Liver Disease
… decreased platelet function and alterations in von Willebrand factor (vWF) that may contribute to hemostatic abnormalities. Hypothesis: Dogs with chronic liver disease have prolonged platelet closure time (CT), assessed with the PFA-100®, and buccal mucosal bleeding time (BMBT), and increased …
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The Role of YAP/TAZ in von Willebrand Factor Gene Expression
von Willebrand Factor (VWF) is a large multimeric glycoprotein with important procoagulant roles in the circulation, including mediating platelet adhesion at sites of vascular injury and stabilizing Factor VIII in the plasma. VWF expression and activity is critically regulated to protect against …
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The Influence of Resistance Training on Primary Hemostatic Responses
… Blood samples were analyzed for platelet count, von Willebrand Factor (vWF), Beta Thromboglobulin (β-TG) and Platelet Factor 4 (PF4).<strong>Results:</strong> Results found significant differences between the RT group and the UT group for measurements of plasma β-TG. Platelet count, vWF and β-TG …
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Interaction Between the Metalloprotease ADAMTS-13 and the Proteins of the Alternative Pathway of the Complement System
Von Willebrand factor (VWF), a multimeric protein that has a central role in hemostasis, has been shown to interact with complement components. However results are contrasting and inconclusive. By studying 20 patients with congenital thrombotic thrombocytopenic purpura (cTTP) who can not cleave VWF …
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Investigating peripheral inflammation induced neuroinflammation in the absence of blood-brain barrier breakdown in relation to Alzheimer’s disease
… manner, and mass spectrometry highlighted Von Willebrand factor (VWF) as a candidate endothelial-derived mediator. Recombinant VWF reproduced microglial inflammatory activation via NFκB signalling. To further assess these mechanisms in vivo, FIRE KO mice lacking microglia and wild-type …
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ADAMTS13 Activity in Dogs with Chronic Enteropathies
… type 1 motif, member 13 (ADAMTS13), a von Willebrand factor (vWF) cleaving enzyme, and increased circulating vWF. The primary aim of this study is to assess plasma ADAMTS13 activity, vWF antigen (vWF:Ag) concentration, and vWF collagen binding activity (vWF:CBA) in dogs with CE. …
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Studies of ADAMTS13 expression and activity in the kidney
Von Willebrand factor (VWF) is an abundant plasma glycoprotein involved in platelet adhesion and aggregation at sites of vascular injury. ADAMTS13 is the sole physiological VWF-cleaving protease, thus regulating the size of thrombus growth. Dysfunctional ADAMTS13 leads to thrombotic …
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Genetic characterization of families with von Willebrand disease
von Willebrand disease (VWD) is the most common hereditary bleeding disorder. It is caused by quantitative and/or qualitative defects of the von Willebrand factor (VWF). The severity of the disease can vary considerably, as can the hereditary patterns. The variable phenotypes of VWD have given rise …
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Role of von Willebrand factor in shear induced platelet accumulation in a microfluidic device
… by platelets adhering via the glycoprotein von Willebrand factor (vWF). To investigate the relative contributions of vWF and platelets in high shear thrombosis, the present work developed a microfluidic thrombosis assay to meet low blood volume requirements and fluid shear conditions …
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Characterization of platelet glycoprotein Ib-IX-V: von Willebrand factor interaction under shear conditions
… between platelet glycoprotein (GP) Ib and von Willebrand factor (VWF). In the first part of the work, we evaluated the kinetics of interaction between platelet GP Ib-IX-V complex and VWF under arterial flow conditions. The GP Ibalpha subunit of GP Ib complex binds to VWF through the Al …
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A Microfluidic Approach For Investigating The Role Of Blood Flow In Thrombosis
… plasma at pathological rates to aggregate von Willebrand factor (VWF) into insoluble fibers held in place by a micropost. VWF fibers were non-amyloid and resistant to ADAMTS13 and tissue plasminogen activator. Factors XIIa and XIa were captured in VWF fibers during aggregation, and could …
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Redefining endothelial progenitor cells using a proteomics approach
… acquire "endothelial" characteristics (CD31, von Willebrand factor [VWF], lectin-binding), and angiogenic properties. In a large population-based study (n =526), platelets emerged as a positive predictor for the number of colony-forming units and early outgrowth EPCs. This study provides the …
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Development and validation of an in vitro human model of drug-induced vascular injury
… determine whether DIVI was recapitulated ex vivo von Willebrand factor (VWF) release, one of the hallmarks of DIVI, was analysed using four drugs reported in the literature to produce DIVI. The same four drugs were then tested in human EC and SMC for the following features of DIVI: (1) VWF …
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Examining Cellular Interactions and Response to Chemotherapy in The Glioblastoma Perivascular Niche
… of LN229 cells towards HUVECs in co-cultures. Von Willebrand factor (vWF) was co-expressed with glial fibrillary acidic protein (GFAP) in up to 40% of LN229 cells after 14 days in co-culture in collagen (2.2 mg/mL) and HyStem-C® gels. The expression of vWF indicates the early stages of …
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