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Showing 1 to 20 of 66 for “"Von Willebrand"”.
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Fator de Von Willebrand no adenocarcinoma colorretal
… o processo de hemostasia primária, o fator de von Willebrand. Esta proteína é liberada pelas células endoteliais e pelas plaquetas e seus níveis estão elevados em situações clínicas em que há proliferação ou dano endotelial. Nos pacientes com câncer, o fator de von Willebrand, além de servir …
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Genetic characterization of families with von Willebrand disease
von Willebrand disease (VWD) is the most common hereditary bleeding disorder. It is caused by quantitative and/or qualitative defects of the von Willebrand factor (VWF). The severity of the disease can vary considerably, as can the hereditary patterns. The variable phenotypes of VWD have given rise …
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Aberrant and Alternative Splicing of von Willebrand Factor
von Willebrand disease (VWD) is the most commonly inherited bleeding disorder in humans resulting from quantitative deficiencies or qualitative defects of von Willebrand factor (VWF). VWD can be caused by a variety of mutations throughout the VWF gene, the majority of which are missense changes. …
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PATHOPHYSIOLOGY OF VON WILLEBRAND FACTOR IN BLEEDING AND THROMBOSIS
von Willebrand factor (VWF) is a multimeric glycoprotein mainly known to be involved in primary hemostasis recruiting platelets at the site of damaged vessels and acting as factor VIII (FVIII) carrier. Quantitative or qualitative alteration of VWF protein is responsible for von Willebrand disease …
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CLINICAL AND LABORATORY CHARACTERISATION OF ACQUIRED VON WILLEBRAND SYNDROME
Background: Acquired von Willebrand syndrome (AVWS) is a rare bleeding disorder due to reduced or dysfunctional VWF in individuals without a personal or familial bleeding history. It is associated with systemic diseases such as lymphoproliferative (LPDs) and myeloproliferative neoplasms (MPNs), …
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Determination of ADAMTS13 Susceptibility in Type IIA von Willebrand Disease
<p>von Willebrand Disease (vWD) is a bleeding disorder caused by a deficiency in von Willebrand Factor (vWF), a large glycoprotein that assists in coagulation. Specifically, large vWF multimers in the blood stream are key components in starting the coagulation cascade. vWF is cleaved by the …
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The Role of YAP/TAZ in von Willebrand Factor Gene Expression
von Willebrand Factor (VWF) is a large multimeric glycoprotein with important procoagulant roles in the circulation, including mediating platelet adhesion at sites of vascular injury and stabilizing Factor VIII in the plasma. VWF expression and activity is critically regulated to protect against …
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Understanding the Role of von Willebrand Factor (VWF) in Angiogenesis and Angiodysplasia
von Willebrand factor (VWF) is a large multimeric glycoprotein essential for hemostasis, mediating platelet adhesion to sites of vascular injury and stabilizing coagulation factor VIII (FVIII) in circulation. Deficiency or dysfunction of VWF results in von Willebrand disease (VWD), the most common …
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VON WILLEBRAND DISEASE: NEW INSIGHTS INTO THE EPIDEMIOLOGY, PATHOPHYSIOLOGY AND GENOTYPE/PHENOTYPE CORRELATION
La malattia di von Willebrand (VWD) è il disturbo emorragico congenito più comune ed è dovuta a difetti quantitativi (VWD di tipo 1 e di tipo 3) o qualitativi (VWD di tipo 2) della glicoproteina fattore di von Willebrand (VWF). Questa tesi mirava a fornire nuove informazioni sull'epidemiologia, …
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Role of von Willebrand factor in shear induced platelet accumulation in a microfluidic device
… by platelets adhering via the glycoprotein von Willebrand factor (vWF). To investigate the relative contributions of vWF and platelets in high shear thrombosis, the present work developed a microfluidic thrombosis assay to meet low blood volume requirements and fluid shear conditions …
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Characterization of platelet glycoprotein Ib-IX-V: von Willebrand factor interaction under shear conditions
… between platelet glycoprotein (GP) Ib and von Willebrand factor (VWF). In the first part of the work, we evaluated the kinetics of interaction between platelet GP Ib-IX-V complex and VWF under arterial flow conditions. The GP Ibalpha subunit of GP Ib complex binds to VWF through the Al …
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von Willebrand factor interaction with subendothelial collagens and platelet surface receptor GPIBalpha under shear conditions
… mechanisms of binding interaction among von Willebrand factor, subendothelium and platelets under physiological shear conditions are important medically in hemostasis and thrombosis. By binding both subendothelial collagens and platelet surface receptors GPIbalpha, multimeric vWf acts as …
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Pathogenicity assessment of genetic variants in von Willebrand disease using quantitative, qualitative, and functional approaches
Von Willebrand disease (VWD) is the most common inherited bleeding disorder. It is defined by a deficiency or dysfunction of plasma von Willebrand factor (VWF), a glycoprotein with a multifaceted role in haemostasis. The majority of circulating VWF is synthesised and released by endothelial cells …
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Ο πολυδιάστατος ρόλος του παράγοντα von Willebrand πέρα από την αιμορραγία. Μοριακές, αγγειακές και φλεγμονώδεις επιδράσεις
Ο παράγοντας von Willebrand (VWF) αποτελεί μια γλυκοπρωτεΐνη, που διαδραματίζει κεντρικό ρόλο στην αιμόσταση κυρίως μέσω της αλληλεπίδρασης του με τον παράγοντα VIII, τα αιμοπετάλια και το κολλαγόνο . Πέρα όμως των παραδοσιακών του λειτουργιών, φαίνεται πως εμπλέκεται σε ένα πλήθος μοριακών …
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The role of von Willebrand factor and its cleaving protease, ADAMTS13, in young patients with HIV-related stroke.
… uncommonly seen in young adults. High levels of von Willebrand factor (VWF), a protein with key roles in platelet adhesion and aggregation, and low levels of A Disintegrin and Metalloproteinase with a Thrombospondin type 1 motif, member 13 (ADAMTS13), the protease that cleaves ultra large VWF …
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Expressionsmuster der Adhäsionsmoleküle P-Selektin, von Willebrand-Faktor und PECAM-1 in der Lunge von Todesfällen durch Verbrennungsschock versus Verblutungsschock
… "Verblutungsschock" wurden die Lungenpräparate von jeweils 30 Fällen aus dem Sektionsgut des Rechtsmedizinischen Instituts der Universität Freiburg anhand immunhistochemischer Färbungen mit P-Selektin, von-Willebrand-Faktor (vWF) und PECAM-1 untersucht. Die Untersuchungsergebnisse zeigten …
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The regulation of the hepcidin by modulators of the bone morphogenetic protein (BMP) pathway
… known BMP, BMP8b, and the clotting factor, von Willebrand Factor which were also found to be significantly increased in the liver of the HPX mouse, were investigated as potential regulators of hepcidin. BMPSb has the potential to form heterodimeric complexes with other BMP members and …
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Effects of nutrition and ultrasound imaging on the cardiovascular system
… for measurement of one of the biomarkers, von Willebrand Factor (Chapter 2). Effects of contrast ultrasound on von Willebrand Factor and atheroma thickness were observed. Next, another rabbit study was performed to assess the effect of contrast ultrasound on Hsp70, a cellular stress …
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A genome-wide association study in chronic thromboembolic pulmonary hypertension and the ADAMTS13-VWF axis
… consequences including variation in plasma von Willebrand factor (VWF) levels. Abnormalities in haemostasis are implicated in CTEPH pathobiology, including elevated levels of VWF, which is cleaved by ADAMTS13 (a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member …
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Multi-scale computational modeling of particle adhesion dynamics under shear flow
… simulation, a physical description of the von Willebrand factor (VWF) mediated thrombus growth process was formulated. The physics-based model captures distinct stages of the thrombus growth process in shear-induced platelet adhesion (SIPA) and platelet-aggregate morphology. It describes …
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